Brain‐Derived Neurotrophic Factor Predicts Mortality Risk in Older Women

OBJECTIVES: To test the hypothesis that low circulating brain‐derived neurotrophic factor (BDNF), a secretory member of the neurotrophin family that has a protective role in neurodegeneration and stress responses and a regulatory role in metabolism, predicts risk of all‐cause mortality in 85‐year‐old men and women.

[1]  M. Schroll,et al.  Genetic priming of a proinflammatory profile predicts low IQ in octogenarians , 2009, Neurobiology of Aging.

[2]  Tuomo Hänninen,et al.  BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study , 2008, Neurobiology of Learning and Memory.

[3]  G. Uhl,et al.  Brain-derived neurotrophic factor and obesity in the WAGR syndrome. , 2008, The New England journal of medicine.

[4]  C. Bever,et al.  Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis , 2008, Journal of the Neurological Sciences.

[5]  S. Rantapää-Dahlqvist,et al.  BDNF in RA: Downregulated in plasma following anti-TNF treatment but no correlation with inflammatory parameters , 2008, Clinical Rheumatology.

[6]  A. Börjesson-Hanson,et al.  Five-year mortality in relation to dementia and cognitive function in 95-year-olds , 2007, Neurology.

[7]  H. Manji,et al.  New insights into BDNF function in depression and anxiety , 2007, Nature Neuroscience.

[8]  C. Sommer,et al.  Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis , 2007, Stroke.

[9]  S. Calza,et al.  Low brain‐derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients , 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[10]  N. Secher,et al.  Brain-derived neurotrophic factor (BDNF) and type 2 diabetes , 2007, Diabetologia.

[11]  Serge Nef,et al.  Brain-Derived Neurotrophic Factor Conditional Knockouts Show Gender Differences in Depression-Related Behaviors , 2007, Biological Psychiatry.

[12]  G. Hotamisligil,et al.  Inflammation and metabolic disorders , 2006, Nature.

[13]  F. Sohrabji,et al.  Estrogen–BDNF interactions: Implications for neurodegenerative diseases , 2006, Frontiers in Neuroendocrinology.

[14]  G. Ramakers,et al.  Insulin signaling in the central nervous system: Learning to survive , 2006, Progress in Neurobiology.

[15]  C. Yasutake.  Serum BDNF, TNF- α and IL-1β levels in dementia patients , 2006, European Archives of Psychiatry and Clinical Neuroscience.

[16]  K. Kuroda,et al.  Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. , 2006, European archives of psychiatry and clinical neuroscience.

[17]  D. Porte,et al.  Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans. , 2005, Diabetes.

[18]  H. Renz,et al.  Tumor necrosis factor-α and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes , 2005, Journal of Neuroimmunology.

[19]  Stuart Maudsley,et al.  BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders , 2004, Trends in Neurosciences.

[20]  J. Virchow,et al.  The impact of age, weight and gender on BDNF levels in human platelets and plasma , 2004, Neurobiology of Aging.

[21]  M. Schroll,et al.  Predicting death from tumour necrosis factor‐alpha and interleukin‐6 in 80‐year‐old people , 2003, Clinical and experimental immunology.

[22]  Ruoyan Chen,et al.  Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation , 2002, Thrombosis and Haemostasis.

[23]  J. Aubry,et al.  Decreased serum brain-derived neurotrophic factor levels in major depressed patients , 2002, Psychiatry Research.

[24]  Y Itakura,et al.  Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. , 2000, Diabetes.

[25]  H. Ichinose,et al.  Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease , 1999, Neuroscience Letters.

[26]  S. Wiegand,et al.  Expression of BDNF and trkB as a function of age and cognitive performance , 1998, Brain Research.

[27]  Svend Kreiner,et al.  Functional ability scales for the elderly: A validation study , 1996 .

[28]  L. Hagerup,et al.  [An investigation of 50-year-old persons in Glostrup in 1964-65]. , 1968, Ugeskrift for laeger.

[29]  C. Martini,et al.  Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments. , 2008, Journal of affective disorders.

[30]  J. B. Walter.  CHAPTER 44 – Diseases of the Central Nervous System , 1982 .