Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization

Reversible tyrosine phosphorylation is an important mechanism in the development and function of the central nervous system. Previously we reported the cloning of the brain-specific protein tyrosine phosphatase PTP-SL (Hendriks et al., 1995) which appeared identical to the 535 carboxyl-terminal amino acids of PTPBR7 (Ogata et al., 1995). We could demonstrate that both isoforms originate from the same single-copy gene through the use of alternative promoters (van den Maagdenberg et al., submitted), in line with recent observations on the rat orthologues of PTP-SL and PTPBR7, PCPTP1-Ce and PCPTP1 (Watenabe et al., 1998). Here we report the assignment of the PTP-SL/PTPBR7 gene (Ptprr, protein tyrosine phosphatase, receptor type, R) to its mouse chromosome region and discuss its candidacy for the nr and mnd neurological mutations in mouse. Materials and methods