Periodically kicked network of RLC oscillators to produce ECG signals

We propose a simple model of the electrical activity of the heart that reproduces realistic healthy electrocardiogram (ECG) signals. The model consists of two RLC linear oscillators periodically kicked by impulses of the main pacemaker with the frequency rate of a real heart. In the proposed model, one oscillator represents the atria, another represents the ventricles, and an electrical cardiac conduction system is included using a coupling capacitor, which can be either unidirectional or bidirectional. The network of the two capacitively coupled oscillators is periodically kicked by the main pacemaker to introduce the periodic forcing of limit cycles into the system; a time delay is introduced to represent the electrical transport delay from atria to ventricles. In this manner, healthy synthetic ECG signals are obtained by combining the signals of the currents of the oscillators. We show that an analytical solution of the model can be obtained when a single impulse is applied. From this, by the superposition principle, a solution with an impulse train is obtained. Note that analytical treatment is a feature not available in current cardiac oscillator models.

[1]  Yves Coudière,et al.  A mathematical model of the Purkinje-muscle junctions. , 2011, Mathematical biosciences and engineering : MBE.

[2]  A. McCulloch,et al.  A collocation-Galerkin finite element model of cardiac action potential propagation , 1994, IEEE Transactions on Biomedical Engineering.

[3]  R. Haiduc Horseshoes in the forced van der Pol system , 2008 .

[4]  R. Artuso,et al.  Nonlinearity effects in the kicked oscillator. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[5]  F ROSENBLATT,et al.  The perceptron: a probabilistic model for information storage and organization in the brain. , 1958, Psychological review.

[6]  Patrick E. McSharry,et al.  A dynamical model for generating synthetic electrocardiogram signals , 2003, IEEE Transactions on Biomedical Engineering.

[7]  Gari D Clifford,et al.  Synthetic ECG generation and Bayesian filtering using a Gaussian wave-based dynamical model , 2010, Physiological measurement.

[8]  Marian Gidea,et al.  Deterministic models for simulating electrocardiographic signals , 2011 .

[9]  Marvin Minsky,et al.  Perceptrons: An Introduction to Computational Geometry , 1969 .

[10]  R. FitzHugh Impulses and Physiological States in Theoretical Models of Nerve Membrane. , 1961, Biophysical journal.

[11]  Pengcheng Shi,et al.  Electrophysiological properties under heart failure conditions in a human ventricular cell: A modeling study , 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[12]  B. Z. Kaplan,et al.  Biological applications of the "Filtered" Van der Pol oscillator , 2008, J. Frankl. Inst..

[13]  E. M. Toledo,et al.  An Electromechanical Left Ventricular Wedge Model to Study the Effects of Deformation on Repolarization during Heart Failure , 2015, BioMed research international.

[14]  Marcelo A. Savi,et al.  An analysis of heart rhythm dynamics using a three-coupled oscillator model , 2009 .

[15]  A Ayatollahi,et al.  A modified Zeeman model for producing HRV signals and its application to ECG signal generation. , 2007, Journal of theoretical biology.

[16]  Alfio Quarteroni,et al.  Integrated Heart—Coupling multiscale and multiphysics models for the simulation of the cardiac function , 2017 .

[17]  V. Urmaliya,et al.  A multidimensional sight on cardiac failure: uncovered from structural to molecular level , 2017, Heart Failure Reviews.

[18]  Lai-Sang Young,et al.  Dynamics of periodically kicked oscillators , 2010, 1004.0565.

[19]  V. Fuster Hurst's the Heart , 1966 .

[20]  Koushik Maharatna,et al.  Fractional dynamical model for the generation of ECG like signals from filtered coupled Van-der Pol oscillators , 2013, Comput. Methods Programs Biomed..

[21]  P. Zoller,et al.  Quantum Chaos in an Ion Trap: The Delta-Kicked Harmonic Oscillator , 1997 .

[22]  Maxim Ryzhii,et al.  A heterogeneous coupled oscillator model for simulation of ECG signals , 2014, Comput. Methods Programs Biomed..