A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors.

[1]  S. Mandrup,et al.  SREBP-1 Dimerization Specificity Maps to Both the Helix-Loop-Helix and Leucine Zipper Domains , 2004, Journal of Biological Chemistry.

[2]  L. Vassilev,et al.  In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 , 2004, Science.

[3]  Ianessa Morantte,et al.  CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ , 2003, Nature.

[4]  E. Wagner,et al.  AP-1: a double-edged sword in tumorigenesis , 2003, Nature Reviews Cancer.

[5]  D. Scudiero,et al.  A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay. , 2003, Analytical biochemistry.

[6]  Maria Miller,et al.  Structural Basis for DNA Recognition by the Basic Region Leucine Zipper Transcription Factor CCAAT/Enhancer-binding Protein α* , 2003, The Journal of Biological Chemistry.

[7]  C. Vinson,et al.  Classification of Human B-ZIP Proteins Based on Dimerization Properties , 2002, Molecular and Cellular Biology.

[8]  D. Scudiero,et al.  Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. , 2002, Cancer research.

[9]  C. Vinson,et al.  Magnesium is required for specific DNA binding of the CREB B-ZIP domain. , 2002, Nucleic acids research.

[10]  D. Scudiero,et al.  Application of high-throughput, molecular-targeted screening to anticancer drug discovery. , 2002, Current topics in medicinal chemistry.

[11]  R. Smart,et al.  CCAAT/enhancer binding protein-β is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Marc Montminy,et al.  CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 , 2001, Nature.

[13]  D. Boger,et al.  A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity. , 2001, Journal of the American Chemical Society.

[14]  M. Olive,et al.  Attractive Interhelical Electrostatic Interactions in the Proline- and Acidic-rich Region (PAR) Leucine Zipper Subfamily Preclude Heterodimerization with Other Basic Leucine Zipper Subfamilies* , 2000, The Journal of Biological Chemistry.

[15]  P. Banks,et al.  Fluorescence Polarization Assays for High Throughput Screening of G Protein-Coupled Receptors , 2000, Journal of biomolecular screening.

[16]  N. Colburn,et al.  Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Nasir Ms,et al.  Fluorescence polarization: an analytical tool for immunoassay and drug discovery. , 1999, Combinatorial chemistry & high throughput screening.

[18]  Thomas D. Y. Chung,et al.  A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.

[19]  T. Pollard,et al.  Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin. , 1998, Biochemistry.

[20]  C. Vinson,et al.  Inter-helical interactions in the leucine zipper coiled coil dimer: pH and salt dependence of coupling energy between charged amino acids. , 1998, Journal of molecular biology.

[21]  D. Ginty,et al.  A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos , 1998, Molecular and Cellular Biology.

[22]  R. Seethala,et al.  A fluorescence polarization competition immunoassay for tyrosine kinases. , 1998, Analytical biochemistry.

[23]  M. Olive,et al.  A Dominant Negative to Activation Protein-1 (AP1) That Abolishes DNA Binding and Inhibits Oncogenesis* , 1997, The Journal of Biological Chemistry.

[24]  U. Schindler,et al.  A high-throughput STAT binding assay using fluorescence polarization. , 1997, Analytical biochemistry.

[25]  M. Jolley,et al.  BODIPY-alpha-casein, a pH-independent protein substrate for protease assays using fluorescence polarization. , 1996, Analytical biochemistry.

[26]  M. Olive,et al.  Extending dimerization interfaces: the bZIP basic region can form a coiled coil. , 1995, The EMBO journal.

[27]  C. Vinson,et al.  A thermodynamic scale for leucine zipper stability and dimerization specificity: e and g interhelical interactions. , 1994, The EMBO journal.

[28]  K. Struhl,et al.  The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex , 1992, Cell.

[29]  W. DeGrado,et al.  DNA-induced increase in the alpha-helical content of C/EBP and GCN4. , 1991, Biochemistry.

[30]  S. McKnight,et al.  Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP. , 1990, Science.