Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers
暂无分享,去创建一个
Imre Mäger | Matthew J. Wood | Martin R. Turner | M. Turner | K. Talbot | M. Wood | Alexander G. Thompson | E. Gray | Sabrina M. Heman-Ackah | I. Mäger | S. E. Andaloussi | Kevin Talbot | Elizabeth Gray | Samir El Andaloussi | S. Andaloussi | M. Turner | Imre Mäger | A. Thompson
[1] Y. Igarashi,et al. Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice* , 2014, The Journal of Biological Chemistry.
[2] Chen Wang,et al. An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity , 2011, Nature Structural &Molecular Biology.
[3] D. Geschwind,et al. Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis , 2008, PLoS genetics.
[4] Takashi Kudo,et al. Induction of neuronal death by ER stress in Alzheimer’s disease , 2004, Journal of Chemical Neuroanatomy.
[5] A. Roses,et al. Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways , 2008 .
[6] Nicolas Chenouard,et al. Prions hijack tunnelling nanotubes for intercellular spread , 2009, Nature Cell Biology.
[7] Henrik J Johansson,et al. Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties. , 2015, Nanomedicine : nanotechnology, biology, and medicine.
[8] R. Margis,et al. Identification of blood microRNAs associated to Parkinsonĭs disease. , 2011, Journal of biotechnology.
[9] MicroRNAs: Possible role in pathogenesis of Parkinson’s disease , 2012, Biochemistry (Moscow).
[10] Pierre J. Magistretti,et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration , 2012, Nature.
[11] Y. Wang,et al. Tunneling-nanotube development in astrocytes depends on p53 activation , 2011, Cell Death and Differentiation.
[12] E. Martin,et al. Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease , 2011, PloS one.
[13] Bruce L. Miller,et al. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis , 2006, Science.
[14] P. Altevogt,et al. Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis , 2007, Neuroscience Letters.
[15] F. Leuven,et al. Axonal transport, tau protein, and neurodegeneration in Alzheimer’s disease , 2002, NeuroMolecular Medicine.
[16] A. Linē,et al. Cell‐free microRNAs as diagnostic, prognostic, and predictive biomarkers for lung cancer , 2013, Genes, Chromosomes and Cancer.
[17] A. McKee,et al. Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease* , 2011, The Journal of Biological Chemistry.
[18] Crislyn D'Souza-Schorey,et al. Microvesicles: mediators of extracellular communication during cancer progression , 2010, Journal of Cell Science.
[19] D. Standaert,et al. LRRK2 secretion in exosomes is regulated by 14-3-3. , 2013, Human molecular genetics.
[20] Jun Wang,et al. Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes* , 2012, The Journal of Biological Chemistry.
[21] D. Cleveland,et al. Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond , 2009, The Journal of cell biology.
[22] A. Hill,et al. Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms , 2014, Proceedings of the National Academy of Sciences.
[23] G. Comi,et al. Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles , 2013, Cell Death and Differentiation.
[24] Andrew F. Hill,et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles , 2014, Journal of extracellular vesicles.
[25] S. Hirai,et al. ALZHEIMER‐TYPE DEMENTIA: DIFFUSE TYPE OF SENILE PLAQUES DEMONSTRATED BY β PROTEIN IMMUNOSTAINING , 1989, Progress in clinical and biological research.
[26] H. Shill,et al. Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology , 2014, PloS one.
[27] Alzheimer's disease beta-amyloid peptides are released in association with exosomes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[28] I. Mackenzie,et al. The neuropathology associated with repeat expansions in the C9ORF72 gene , 2014, Acta Neuropathologica.
[29] I. Martin,et al. LRRK2 pathobiology in Parkinson's disease , 2014, Journal of neurochemistry.
[30] M. Zatz,et al. A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13 , 2004, Journal of Medical Genetics.
[31] R. Petersen,et al. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study , 2015, Alzheimer's & Dementia.
[32] K. Josephs. Frontotemporal dementia and related disorders: Deciphering the enigma , 2008, Annals of neurology.
[33] W. Möbius,et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C , 2010, The Journal of cell biology.
[34] H. Akiyama,et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. , 2006, Biochemical and biophysical research communications.
[35] M. Ntzouni,et al. Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival , 2010, The Journal of Neuroscience.
[36] Chris Gardiner,et al. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission , 2011, Neurobiology of Disease.
[37] P. Altevogt,et al. Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation , 2012, PLoS biology.
[38] T. J. Cook,et al. Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease , 2014, Acta Neuropathologica.
[39] M. Turner,et al. Identification of distinct circulating exosomes in Parkinson's disease , 2015, Annals of clinical and translational neurology.
[40] Rong-Fong Shen,et al. Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. , 2009, Biochemical and biophysical research communications.
[41] S. Akbarian,et al. The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism , 2010, PloS one.
[42] Y. Gui,et al. Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease , 2015, Oncotarget.
[43] L. H. Weed. Studies on Cerebro-Spinal Fluid. No. III : The pathways of escape from the Subarachnoid Spaces with particular reference to the Arachnoid Villi. , 1914, The Journal of medical research.
[44] Ryan M. O’Connell,et al. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin , 2015, Nature Communications.
[45] L. Tanoue,et al. Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer , 2012 .
[46] S. Prusiner,et al. A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis , 1997, Journal of virology.
[47] E. Cisneros,et al. Analysis of exosome release and its prognostic value in human colorectal cancer , 2012, Genes, chromosomes & cancer.
[48] Shivakumar Keerthikumar,et al. ExoCarta: A Web-Based Compendium of Exosomal Cargo. , 2016, Journal of molecular biology.
[49] S. Dowdy,et al. Pathologic Prion Protein Infects Cells by Lipid-Raft Dependent Macropinocytosis , 2008, PloS one.
[50] R. Schiffelers,et al. Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes , 2012, Journal of extracellular vesicles.
[51] Dongmei Sun,et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.
[52] C. Warren Olanow,et al. Altered Proteasomal Function in Sporadic Parkinson's Disease , 2003, Experimental Neurology.
[53] Nigel J. Cairns,et al. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies , 1998, Neuroscience Letters.
[54] Michele Guescini,et al. Astrocytes and Glioblastoma cells release exosomes carrying mtDNA , 2009, Journal of Neural Transmission.
[55] A. Roher,et al. Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. , 2000, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[56] Julia Christina Gross,et al. Active Wnt proteins are secreted on exosomes , 2012, Nature Cell Biology.
[57] A. Ludolph,et al. Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis , 2013, Acta Neuropathologica Communications.
[58] S. Lindquist,et al. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. , 2008, Proceedings of the National Academy of Sciences of the United States of America.
[59] S. Tenzer,et al. Oligodendrocytes secrete exosomes containing major myelin and stress‐protective proteins: Trophic support for axons? , 2007, Proteomics. Clinical applications.
[60] Timothy J Keyes,et al. Structural and functional features of central nervous system lymphatics , 2015, Nature.
[61] W. Hung,et al. Intense Superoxide Dismutase‐1 Immunoreactivity in Intracytoplasmic Hyaline Inclusions of Familial Amyotrophic Lateral Sclerosis with Posterior Column Involvement , 1996, Journal of neuropathology and experimental neurology.
[62] P. Lansbury,et al. Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. , 1997, Annual review of biochemistry.
[63] Michael Liem,et al. Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma , 2013, Proteomics.
[64] F. Wendler,et al. Extracellular vesicles round off communication in the nervous system , 2016, Nature Reviews Neuroscience.
[65] A. Hill,et al. Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells , 2012, Nucleic acids research.
[66] B. Hyman,et al. Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinson's Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity , 1998, Journal of neuropathology and experimental neurology.
[67] K. Blennow,et al. Understanding Biomarkers of Neurodegeneration: Ultrasensitive detection techniques pave the way for mechanistic understanding , 2015, Nature Medicine.
[68] Y. Kawahara,et al. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes , 2012, Proceedings of the National Academy of Sciences.
[69] T. Crow,et al. Induction of β(A4)-amyloid in primates by injection of Alzheimer’s disease brain homogenate , 2007, Molecular Neurobiology.
[70] Deyu Li,et al. TDP-43 is intercellularly transmitted across axon terminals , 2015, The Journal of cell biology.
[71] J. Lötvall,et al. Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA , 2010, PloS one.
[72] M. Wood,et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes , 2011, Nature Biotechnology.
[73] G. Raposo,et al. Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles , 2008, Biology of the cell.
[74] E. Bieberich,et al. Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease , 2014, Neurobiology of Aging.
[75] E. Mugnaini,et al. FUS‐immunoreactive inclusions are a common feature in sporadic and non‐SOD1 familial amyotrophic lateral sclerosis , 2010, Annals of neurology.
[76] R. Hauser,et al. Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease , 2008, Nature Medicine.
[77] S. Thibodeau,et al. Characterization of human plasma-derived exosomal RNAs by deep sequencing , 2013, BMC Genomics.
[78] Kévin Carayon,et al. Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation* , 2011, Journal of Biological Chemistry.
[79] Lynne T. Bemis,et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research , 2013, Journal of extracellular vesicles.
[80] P. Callaerts,et al. TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis? , 2014, Trends in molecular medicine.
[81] E. Wang,et al. Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma , 2014, Front. Mol. Neurosci..
[82] Noah W. Gray,et al. Alsin Is a Rab5 and Rac1 Guanine Nucleotide Exchange Factor* , 2004, Journal of Biological Chemistry.
[83] David W. Holman,et al. Ex vivo model of cerebrospinal fluid outflow across human arachnoid granulations. , 2008, Investigative ophthalmology & visual science.
[84] M. Yáñez-Mó,et al. The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes* , 2013, The Journal of Biological Chemistry.
[85] Miguel C. Seabra,et al. Rab27a and Rab27b control different steps of the exosome secretion pathway , 2010, Nature Cell Biology.
[86] Stanley N Cohen,et al. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein , 2012, Proceedings of the National Academy of Sciences.
[87] Murray Grossman,et al. Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis , 2013, Annals of neurology.
[88] J. Collinge,et al. Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis , 2010, PloS one.
[89] P. Saftig,et al. The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. , 2011, Developmental cell.
[90] C. Dieterich,et al. Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers. , 2014, Brain : a journal of neurology.
[91] He-Jin Lee,et al. Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. , 2008, Biochemical and biophysical research communications.
[92] A. Winslow,et al. Exosomal cell-to-cell transmission of alpha synuclein oligomers , 2012, Molecular Neurodegeneration.
[93] Brian Spencer,et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein , 2009, Proceedings of the National Academy of Sciences.
[94] Graça Raposo,et al. Extracellular vesicles: Exosomes, microvesicles, and friends , 2013, The Journal of cell biology.
[95] Luz Claudio,et al. Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients , 1995, Acta Neuropathologica.
[96] S. Prusiner. Novel proteinaceous infectious particles cause scrapie. , 1982, Science.
[97] Christian Münch,et al. Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells , 2011, Proceedings of the National Academy of Sciences.
[98] Prion strains are differentially released through the exosomal pathway , 2015, Cellular and Molecular Life Sciences.
[99] Jung Hoon Jung,et al. Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo , 2013, Molecular Brain.
[100] P. Brundin,et al. Acceleration of α-Synuclein Aggregation by Exosomes* , 2014, The Journal of Biological Chemistry.
[101] Hiroyuki Arai,et al. MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease. , 2014, Journal of Alzheimer's disease : JAD.
[102] T. Peng,et al. Mitochondrial dysfunction in Parkinson's disease. , 1999, Biochemical Society symposium.
[103] H. Buermans,et al. Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions , 2012, Nucleic acids research.
[104] Koji Yoshimoto,et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. , 2005, The New England journal of medicine.
[105] R. Cappai,et al. Packaging of prions into exosomes is associated with a novel pathway of PrP processing , 2007, The Journal of pathology.
[106] B. Mollenhauer,et al. Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies , 2015, Brain : a journal of neurology.
[107] H. Braak,et al. Staging of brain pathology related to sporadic Parkinson’s disease , 2003, Neurobiology of Aging.
[108] Aled Clayton,et al. Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.
[109] F. S. Domingues,et al. Overexpression of blood microRNAs 103a, 30b, and 29a in l-dopa–treated patients with PD , 2015, Neurology.
[110] Graca Raposo,et al. ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles , 2009, Current Biology.
[111] W. Faigle,et al. Cells release prions in association with exosomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[112] Jennifer Luebke,et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation , 2015, Nature Neuroscience.
[113] G. Lachenal,et al. Exosomes are released by cultured cortical neurones , 2006, Molecular and Cellular Neuroscience.
[114] D. Mann,et al. Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis , 2008, Acta Neuropathologica.
[115] D. Mann,et al. Prion-like properties of pathological TDP-43 aggregates from diseased brains. , 2013, Cell reports.
[116] A. Hill,et al. Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid. , 2008, Veterinary immunology and immunopathology.
[117] J. Sixma,et al. Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules , 1999 .
[118] Lesley Cheng,et al. Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood , 2014, Journal of extracellular vesicles.
[119] Danail Bonchev,et al. A Network View on Parkinson's Disease , 2013, Computational and structural biotechnology journal.
[120] Pei-Chang Wang,et al. MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease. , 2014, Molecular medicine reports.
[121] Simon C Watkins,et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. , 2004, Blood.
[122] Alvaro G. Hernandez,et al. Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers , 2015, PloS one.
[123] G. Jicha,et al. Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease , 2012, Experimental Neurology.
[124] R. Petersen,et al. Sanders-brown Center on Aging Faculty Publications Aging Altered Lysosomal Proteins in Neural-derived Plasma Exosomes in Preclinical Alzheimer Disease Repository Citation , 2022 .
[125] H. Braak,et al. Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.
[126] L. Tan,et al. Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases , 2014, Molecular Neurobiology.
[127] A. Möller,et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma , 2015, Journal of extracellular vesicles.
[128] R. Pink,et al. Routes and mechanisms of extracellular vesicle uptake , 2014, Journal of extracellular vesicles.
[129] P. Verkade,et al. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[130] C. Teunissen,et al. Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. , 2014, Journal of proteomics.
[131] A. Haqqani,et al. Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells , 2013, Fluids and Barriers of the CNS.
[132] T. Crow,et al. Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy. , 1994, Molecular neurobiology.
[133] J. Cooper,et al. Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice , 2014, Movement disorders : official journal of the Movement Disorder Society.
[134] R. Midha,et al. Lymphatic cerebrospinal fluid absorption pathways in neonatal sheep revealed by subarachnoid injection of Microfil , 2003, Neuropathology and applied neurobiology.
[135] L. O’Driscoll,et al. Biological properties of extracellular vesicles and their physiological functions , 2015, Journal of extracellular vesicles.
[136] Olivier Elemento,et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection , 2014, Cell Research.
[137] P. Altevogt,et al. Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation , 2014, Journal of Neuroimmunology.
[138] E. Clementi,et al. Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism , 2012, The EMBO journal.
[139] Gema Moreno-Bueno,et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET , 2012, Nature Medicine.
[140] A. Hill,et al. Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions* , 2016, The Journal of Biological Chemistry.
[141] S. Papapetropoulos,et al. Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects , 2009, Movement disorders : official journal of the Movement Disorder Society.
[142] G. Halliday,et al. α-Synucleinopathy phenotypes. , 2014, Parkinsonism & related disorders.
[143] D. Cleveland,et al. The Seeds of Neurodegeneration: Prion-like Spreading in ALS , 2011, Cell.
[144] Y. Igarashi,et al. A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide , 2020 .
[145] S. Lindquist,et al. The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis , 2008, Proceedings of the National Academy of Sciences.
[146] H. D. del Portillo,et al. Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals , 2015, Journal of extracellular vesicles.
[147] P. Damier,et al. Pathological lesions in colonic biopsies during Parkinson’s disease , 2008, Gut.
[148] S. Elmore. Apoptosis: A Review of Programmed Cell Death , 2007, Toxicologic pathology.
[149] A. Roher,et al. Evidence for Seeding of β-Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in β-Amyloid Precursor Protein-Transgenic Mice , 2000, The Journal of Neuroscience.
[150] G. Poste. Bring on the biomarkers , 2011, Nature.
[151] Jochen H Weishaupt,et al. Serum microRNAs in sporadic amyotrophic lateral sclerosis , 2015, Neurobiology of Aging.
[152] S. Pomeroy,et al. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. , 2011, Nature communications.
[153] E. Bigio,et al. Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration , 2009, Acta Neuropathologica.
[154] Hyman M. Schipper,et al. MicroRNA Expression in Alzheimer Blood Mononuclear Cells , 2007, Gene regulation and systems biology.
[155] R A Crowther,et al. Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. , 1998, Neuroscience letters.
[156] J. Trojanowski,et al. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.
[157] Smita Patel,et al. Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates , 2005, The Journal of Neuroscience.
[158] B. Pan,et al. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor , 1983, Cell.
[159] C. Théry,et al. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. , 2014, Annual review of cell and developmental biology.
[160] A. Ludolph,et al. Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases , 2014, Amyotrophic lateral sclerosis & frontotemporal degeneration.
[161] G. Lederkremer,et al. Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress , 2013, Nature Communications.
[162] C. Rowe,et al. Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment , 2014, Molecular Psychiatry.
[163] E. Kroh,et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma , 2011, Proceedings of the National Academy of Sciences.
[164] Y. Igarashi,et al. Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia , 2012, The Journal of Biological Chemistry.