Evaluation of a Disposable Device for Patient-Controlled Epidural Analgesia after Caesarean Section

We evaluated a disposable device (Baxter PCA Infusor) for patient-controlled epidural analgesia (PCEA) using pethidine in twenty women after lower segment caesarean section. Efficacy, as measured by visual analogue pain scores, was comparable with historical controls from PCEA studies using electronic devices. Three patients reported inadequate analgesia, attributable in two cases to problems with the epidural catheter. PCEA was stopped in one patient because of side-effects. Pethidine consumption ranged from 125 to 1500 mg (median 575 mg) in 48 hours. Plasma concentrations of pethidine varied widely. Disposable devices for PCEA after caesarean section provide an alternative to bolus administration or PCEA using more expensive and cumbersome electronic devices, although we suggest currently available apparatus requires modifications to improve clinical performance.

[1]  S. Chrubasik,et al.  Selection of the optimum opioid for extradural administration in the treatment of postoperative pain. , 1995, British journal of anaesthesia.

[2]  O. Rosaeg,et al.  Epidural opioid analgesia after Caesarean section: a comparison of patient-controlled analgesia with meperidine and single bolus injection of morphine , 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[3]  M. Paech,et al.  Meperidine for Patient‐controlled Analgesia after Cesarean Section Intravenous Versus Epidural Administration , 1994, Anesthesiology.

[4]  R. Russell,et al.  A comparison of epidural diamorphine with intravenous patient‐controlled analgesia using the Baxter infusor following Caesarean section , 1993 .

[5]  P. Macintyre,et al.  Norpethidine toxicity and patient controlled analgesia. , 1993, British journal of anaesthesia.

[6]  M. Akçabay,et al.  Perineural pethidine: effects of different doses on nerve conduction. , 1993, European journal of anaesthesiology.

[7]  D. Gambling,et al.  A comparative study of patient-controlled epidural fentanyl and single dose epidural morphine for post-caesarean analgesia , 1993, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[8]  P. White,et al.  Epidural patient-controlled analgesia: an alternative to intravenous patient-controlled analgesia for pain relief after cesarean delivery. , 1992, Anesthesia and analgesia.

[9]  J. A. Gillespie,et al.  Evaluation of a disposable patient-controlled analgesia device in children. , 1992, British journal of anaesthesia.

[10]  D. Amar,et al.  Epidural patient-controlled analgesia after cesarean section: buprenorphine-0.015% bupivacaine with epinephrine versus fentanyl-0.015% bupivacaine with and without epinephrine. , 1992, Anesthesia and analgesia.

[11]  D. Rowbotham,et al.  Electronic and disposable patient‐controlled analgesia systems , 1992, Anaesthesia.

[12]  D. Breen,et al.  Patient‐controlled on‐demand epidural fentanyl , 1991, Anaesthesia.

[13]  K. Chan,et al.  Determination of pethidine and its major metabolites in human urine by gas chromatography. , 1991, Journal of chromatography.

[14]  I. Wilson,et al.  ANALGESIA FOLLOWING EXTRADURAL AND I.M. PETHIDINE IN POST-CAESAREAN SECTION PATIENTS , 1990 .

[15]  D. Rowbotham,et al.  A disposable device for patient‐controlled analgesia with fentanyl , 1989, Anaesthesia.

[16]  P. White,et al.  Epidural patient-controlled analgesia (PCA): an alternative to continuous epidural infusions , 1989, Pain.

[17]  D. Hartvig,et al.  Patient-controlled analgesia with extradural morphine or pethidine. , 1988, British journal of anaesthesia.

[18]  P. Hartvig,et al.  Pharmacokinetics of Epidural Morphine and Meperidine in Humans , 1987, Anesthesiology.

[19]  S. Datta,et al.  Effect of diluent volume on analgesia produced by epidural fentanyl , 1987, Regional Anesthesia & Pain Medicine.

[20]  D. Frewin,et al.  A Comparative Study of Techniques of Postoperative Analgesia following Caesarean Section and Lower Abdominal Surgery , 1985 .

[21]  P. Brownridge Epidural and intrathecal opiates for postoperative pain relief , 1983, Anaesthesia.

[22]  K. Austin,et al.  Relationship Between Blood Meperidine Concentrations and Analgesic Response: A Preliminary Report , 1980, Anesthesiology.

[23]  M. Kendall,et al.  A quantitative gas-liquid chromatographic method for the determination of pethidine and its metabolites, norpethidine and pethidine N-oxide in human biological fluids , 1974 .