Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide.

[1]  M. Pasenkiewicz-Gierula,et al.  High Cholesterol/Low Cholesterol: Effects in Biological Membranes: A Review , 2017, Cell Biochemistry and Biophysics.

[2]  A. Ulrich,et al.  Oriented Circular Dichroism: A Method to Characterize Membrane-Active Peptides in Oriented Lipid Bilayers. , 2016, Accounts of chemical research.

[3]  D. Engelman,et al.  pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo , 2014, ACS chemical biology.

[4]  D. Engelman,et al.  Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer , 2014, Proceedings of the National Academy of Sciences.

[5]  A. Moshnikova,et al.  Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment , 2014, Scientific Reports.

[6]  D. Engelman,et al.  pH (low) insertion peptide (pHLIP) targets ischemic myocardium , 2012, Proceedings of the National Academy of Sciences.

[7]  D. Engelman,et al.  Membrane physical properties influence transmembrane helix formation , 2012, Proceedings of the National Academy of Sciences.

[8]  D. Engelman,et al.  Modulation of the pHLIP transmembrane helix insertion pathway. , 2012, Biophysical journal.

[9]  D. C. Mitchell.  Progress in understanding the role of lipids in membrane protein folding. , 2012, Biochimica et biophysica acta.

[10]  D. Engelman,et al.  In Vivo pH Imaging with 99mTc-pHLIP , 2012, Molecular Imaging and Biology.

[11]  D. Engelman,et al.  Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP , 2011, Molecular Imaging and Biology.

[12]  V. Anbazhagan,et al.  The membrane environment modulates self-association of the human GpA TM domain--implications for membrane protein folding and transmembrane signaling. , 2010, Biochimica et biophysica acta.

[13]  D. Engelman,et al.  Tuning the insertion properties of pHLIP. , 2010, Biochimica et biophysica acta.

[14]  D. Engelman,et al.  pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path , 2010, Proceedings of the National Academy of Sciences.

[15]  D. Engelman,et al.  Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane , 2008, Proceedings of the National Academy of Sciences.

[16]  R. Templer,et al.  Phosphatidylglycerol lipids enhance folding of an alpha helical membrane protein. , 2008, Journal of molecular biology.

[17]  G. Meer,et al.  Membrane lipids: where they are and how they behave , 2008, Nature Reviews Molecular Cell Biology.

[18]  D. Engelman,et al.  A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. , 2007, Biophysical journal.

[19]  D. Engelman,et al.  Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo , 2007, Proceedings of the National Academy of Sciences.

[20]  T. McIntosh,et al.  Roles of bilayer material properties in function and distribution of membrane proteins. , 2006, Annual review of biophysics and biomolecular structure.

[21]  Pål Puntervoll,et al.  The major outer membrane protein of Fusobacterium nucleatum (FomA) folds and inserts into lipid bilayers via parallel folding pathways. , 2006, Journal of molecular biology.

[22]  Anthony G Lee,et al.  How lipids affect the activities of integral membrane proteins. , 2004, Biochimica et biophysica acta.

[23]  R. Hodges,et al.  Stabilizing and Destabilizing Clusters in the Hydrophobic Core of Long Two-stranded α-Helical Coiled-coils* , 2004, Journal of Biological Chemistry.

[24]  D. Kemp,et al.  Dual wavelength parametric test of two-state models for circular dichroism spectra of helical polypeptides: anomalous dichroic properties of alanine-rich peptides. , 2003, Journal of the American Chemical Society.

[25]  L. Tamm,et al.  Secondary and tertiary structure formation of the beta-barrel membrane protein OmpA is synchronized and depends on membrane thickness. , 2002, Journal of molecular biology.

[26]  Y. Reshetnyak,et al.  Decomposition of protein tryptophan fluorescence spectra into log-normal components. III. Correlation between fluorescence and microenvironment parameters of individual tryptophan residues. , 2001, Biophysical journal.

[27]  R. Templer,et al.  Modulation of folding and assembly of the membrane protein bacteriorhodopsin by intermolecular forces within the lipid bilayer. , 1999, Biochemistry.

[28]  G. Heijne,et al.  Genome‐wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms , 1998, Protein science : a publication of the Protein Society.

[29]  G. Olah,et al.  Method of oriented circular dichroism. , 1990, Biophysical journal.

[30]  D. Engelman,et al.  Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles. , 1983, Journal of molecular biology.

[31]  E. Oldfield,et al.  Dynamics of lipids in membranes: Heterogeneity and the role of cholesterol , 1972, FEBS letters.

[32]  M. Balázs,et al.  Dexamethasone decreases membrane fluidity of leukemia cells. , 1990, Leukemia research.

[33]  G. Sherbet.  Membrane fluidity and cancer metastasis. , 1989, Experimental cell biology.