Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Nicholette D. Palmer | P. Elliott | M. Fornage | M. Nalls | C. Gieger | M. Waldenberger | A. Uitterlinden | D. Levy | A. Peters | I. Deary | I. Ntalla | R. Mägi | T. Lehtimäki | E. Boerwinkle | C. Rotimi | S. Bergmann | K. Strauch | P. Ridker | D. Chasman | N. Samani | J. Connell | P. Munroe | M. Caulfield | V. Gudnason | C. Bouchard | J. Jonas | T. Wong | A. Zonderman | M. Evans | T. Rice | E. Tai | B. Horta | S. Kardia | T. Meitinger | K. Lohman | Yongmei Liu | S. Kritchevsky | B. Psaty | D. Gu | B. Penninx | D. Arking | A. Kraja | A. Metspalu | T. Esko | H. Snieder | L. Milani | R. Cooper | J. Rotter | P. Froguel | F. Hsu | R. Rueedi | C. Sitlani | T. Harris | T. Lakka | R. Rauramaa | J. Norris | I. Rudan | M. Swertz | Tangchun Wu | X. Shu | Jian-Min Yuan | W. Koh | W. Zheng | J. Brody | D. Porteous | J. Starr | D. Rao | C. Langefeld | D. Becker | L. Bielak | P. Peyser | Jianjun Liu | T. Sofer | K. Rice | Xiaofeng Zhu | C. Nelson | P. Magnusson | N. Pedersen | C. V. van Duijn | J. Shikany | P. Franks | Xiuqing Guo | C. Sabanayagam | A. Petersmann | A. Teumer | K. North | M. Ikram | S. Harris | K. Christensen | C. Heng | C. Gu | S. Hunt | N. Amin | C. Hayward | O. Polašek | Jennifer A. Smith | Wei Zhao | G. Eiriksdottir | J. Faul | M. Kähönen | D. Weir | T. Rankinen | D. Arnett | M. Feitosa | Y. Sung | T. Winkler | Ching-Yu Cheng | X. Sim | D. Vojinović | J. Marten | S. Musani | Changwei Li | A. Bentley | K. Schwander | Melissa A. Richard | R. Noordam | H. Aschard | T. Bartz | R. Dorajoo | Virginia Fisher | F. Hartwig | A. Horimoto | A. Manning | S. Tajuddin | A. Campbell | Jin-Fang Chai | Xu Chen | J. Divers | Chuan Gao | M. He | P. Komulainen | B. Kühnel | F. Laguzzi | I. Nolte | S. Padmanabhan | Muhammad B. Riaz | F. Takeuchi | B. Tayo | E. Ware | H. Warren | S. Weiss | W. Wen | L. Yanek | U. Broeckel | M. Brumat | G. Burke | M. Canouil | A. Correa | L. de las Fuentes | H. J. de Silva | E. Evangelou | T. Forrester | Y. Friedlander | He Gao | B. Gigante | Jiang He | S. Heikkinen | C. Khor | T. Kilpeläinen | J. Krieger | Yize Li | C. Mckenzie | Y. Milaneschi | J. O'connell | N. Palmer | T. Perls | L. Raffel | P. Schreiner | M. Sims | Yih-Chung Tham | Lihua Wang | W. Wei | Caizheng Yu | D. Bowden | B. Freedman | P. Gasparini | N. Kato | K. Leander | P. van der Harst | L. Wagenknecht | R. V. van Dam | W. Gauderman | D. Mook-Kanamori | T. Kelly | W. Palmas | A. Morrison | A. Ogunniyi | Ching‐Ti Liu | L. Lyytikäinen | Xiaoyin Li | M. Kavousi | M. Dörr | N. Verweij | M. Cocca | G. Girotto | R. Li-Gao | M. Irvin | Yaxing Wang | B. Salako | M. Chee | C. Cabrera | C. Kammerer | D. Vaidya | P. D. de Vries | A. Poveda | B. Yu | D. Liewald | Traci M Bartz | Jennifer A. Brody | A. C. Pereira | Ervin F Fox | Jingjing Liang | S. Sidney | Colleen M. Sitlani | O. Rueda-Ochoa | M. Y. van der Ende | Deng Xuan | M. Brown | J. Yao | A. Smith | Maris Alver | Franco Giulianini | Y. Chen | M. Boissel | P. Marques-Vidal | P. van der harst | M. Y. Van Der Ende | M. Province | A. Pereira | Michael R. Brown | A. Smith | M. Richard | Wei Zhao | M. Kähönen | A. Uitterlinden | Wei Zhao | C. McKenzie | Dhananjay Vaidya | D. Rao | T. Wong | C. V. van Duijn | B. Psaty | Brigitte Kühnel | J. Krieger | T. Wong | C. Nelson | Ervin F. Fox | S. Harris | T. Wong | A. Peters | T. Wong | D. Levy | Wei Zhao | A. Correa | A. Campbell

[1]  Laura J. Scott,et al.  Trans-ethnic association study of blood pressure determinants in over 750,000 individuals , 2018, Nature Genetics.

[2]  Christian Gieger,et al.  Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits , 2018, Nature Genetics.

[3]  Jonathan P. Beauchamp,et al.  Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals , 2018, Nature Genetics.

[4]  Nicholette D. Palmer,et al.  Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries , 2018, PloS one.

[5]  Francesca N. Delling,et al.  Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association , 2018, Circulation.

[6]  Fernando Pires Hartwig,et al.  A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. , 2018, American journal of human genetics.

[7]  D. Posthuma,et al.  Functional mapping and annotation of genetic associations with FUMA , 2017, Nature Communications.

[8]  Nicola J. Rinaldi,et al.  Genetic effects on gene expression across human tissues , 2017, Nature.

[9]  P. Munroe,et al.  Multiancestry Study of Gene–Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale , 2017, Circulation. Cardiovascular genetics.

[10]  N. Risch,et al.  Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation , 2016, Nature Genetics.

[11]  He Zhang,et al.  Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension , 2016, Nature Genetics.

[12]  Claude Bouchard,et al.  Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci , 2016, Nature Genetics.

[13]  A. Chédotal,et al.  Slit-Robo signaling , 2016, Development.

[14]  Xiaofeng Zhu,et al.  The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals , 2016, Nature Genetics.

[15]  Yunlong Liu,et al.  Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats. , 2016, Alcoholism, clinical and experimental research.

[16]  A. Hao,et al.  ZDHHC17 promotes axon outgrowth by regulating TrkA–tubulin complex formation , 2015, Molecular and Cellular Neuroscience.

[17]  G. Kempermann Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. , 2015 .

[18]  Jun S. Liu,et al.  The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans , 2015, Science.

[19]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[20]  Nan Jin,et al.  Socioeconomic status and hypertension: a meta-analysis , 2015, Journal of hypertension.

[21]  R. Mägi,et al.  Quality control and conduct of genome-wide association meta-analyses , 2014, Nature Protocols.

[22]  Amanda Sonnega,et al.  Cohort Profile: the Health and Retirement Study (HRS). , 2014, International journal of epidemiology.

[23]  Yun Ju Sung,et al.  Gene-education interactions identify novel blood pressure loci in the Framingham Heart Study. , 2014, American journal of hypertension.

[24]  J. Shendure,et al.  A general framework for estimating the relative pathogenicity of human genetic variants , 2014, Nature Genetics.

[25]  L. Raymond,et al.  Memory and synaptic deficits in Hip14/DHHC17 knockout mice , 2013, Proceedings of the National Academy of Sciences.

[26]  Vytas P Bindokas,et al.  SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. , 2013, Journal of molecular and cellular cardiology.

[27]  M. Peters,et al.  Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.

[28]  E. Lalli,et al.  Genomic Analysis of Sexual Dimorphism of Gene Expression in the Mouse Adrenal Gland , 2013, Hormone and Metabolic Research.

[29]  Jonathan P. Beauchamp,et al.  GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment , 2013, Science.

[30]  Kenny Q. Ye,et al.  An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.

[31]  Eurie L. Hong,et al.  Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.

[32]  Manolis Kellis,et al.  ChromHMM: automating chromatin-state discovery and characterization , 2012, Nature Methods.

[33]  B. Morris,et al.  Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs , 2011, Hypertension.

[34]  Manolis Kellis,et al.  HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants , 2011, Nucleic Acids Res..

[35]  Andrew Steptoe,et al.  Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women , 2011, Brain, Behavior, and Immunity.

[36]  Tom R. Gaunt,et al.  Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk , 2011, Nature.

[37]  A. Phillips,et al.  The Human Hyaluronan Synthase 2 (HAS2) Gene and Its Natural Antisense RNA Exhibit Coordinated Expression in the Renal Proximal Tubular Epithelial Cell♦ , 2011, The Journal of Biological Chemistry.

[38]  Josée Dupuis,et al.  Meta‐analysis of gene‐environment interaction: joint estimation of SNP and SNP × environment regression coefficients , 2011, Genetic epidemiology.

[39]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[40]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[41]  A. Chédotal,et al.  Moving away from the midline: new developments for Slit and Robo , 2010, Development.

[42]  Peter J Gianaros,et al.  Annals of the New York Academy of Sciences Central Role of the Brain in Stress and Adaptation: Links to Socioeconomic Status, Health, and Disease , 2022 .

[43]  P. O’Reilly,et al.  Genome-wide association study identifies eight loci associated with blood pressure , 2009, Nature Genetics.

[44]  Andrew D. Johnson,et al.  Genome-wide association study of blood pressure and hypertension , 2009, Nature Genetics.

[45]  M. Lyons,et al.  Educational Attainment and the Heritability of Self-Reported Hypertension Among Male Vietnam-Era Twins , 2008, Psychosomatic medicine.

[46]  P. Verstreken,et al.  Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles , 2007, The Journal of cell biology.

[47]  Antigoni L Elefsinioti,et al.  The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14 094 cases and 17 760 controls , 2007, Journal of hypertension.

[48]  E. Reddy,et al.  Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo , 2006, The Journal of cell biology.

[49]  P. Steffen The Cultural Gradient: Culture Moderates the Relationship between Socioeconomic Status (SES) and Ambulatory Blood Pressure , 2006, Journal of Behavioral Medicine.

[50]  Nuala A Sheehan,et al.  Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure , 2005, Statistics in medicine.

[51]  A. Unger,et al.  Racial disparities in hypertension prevalence, awareness, and management. , 2005, Archives of internal medicine.

[52]  N. Glorioso,et al.  Genetic polymorphisms of the β-adrenergic system: association with essential hypertension and response to β-blockade , 2004, The Pharmacogenomics Journal.

[53]  J. Sedor,et al.  Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice , 2003, Mechanisms of Development.

[54]  P. Elliott,et al.  Higher blood pressure in middle-aged American adults with less education—role of multiple dietary factors: The INTERMAP Study , 2003, Journal of Human Hypertension.

[55]  K. Matthews,et al.  Educational Attainment and Coronary and Aortic Calcification in Postmenopausal Women , 2001, Psychosomatic medicine.

[56]  E. Boerwinkle,et al.  C825T Polymorphism of the G Protein &bgr;3-Subunit and Antihypertensive Response to a Thiazide Diuretic , 2001, Hypertension.

[57]  R. Gillum,et al.  Incidence of hypertension and educational attainment: the NHANES I epidemiologic followup study. First National Health and Nutrition Examination Survey. , 2000, American journal of epidemiology.

[58]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[59]  T. Martin,et al.  Ca2+-Dependent Activator Protein for Secretion Is Critical for the Fusion of Dense-Core Vesicles with the Membrane in Calf Adrenal Chromaffin Cells , 1999, The Journal of Neuroscience.

[60]  P. Metcalf,et al.  African American-white differences in lipids, lipoproteins, and apolipoproteins, by educational attainment, among middle-aged adults: the Atherosclerosis Risk in Communities Study. , 1998, American journal of epidemiology.

[61]  G. Watt,et al.  Individual social class, area-based deprivation, cardiovascular disease risk factors, and mortality: the Renfrew and Paisley Study. , 1998, Journal of epidemiology and community health.

[62]  L. Garfinkel,et al.  Trends in cigarette smoking in the United States. , 1997, Preventive medicine.

[63]  A. Nissinen,et al.  Dietary Sodium and Potassium, Socioeconomic Status and Blood Pressure in a Chinese Population , 1996, Appetite.

[64]  J E Keil,et al.  Socioeconomic factors and cardiovascular disease: a review of the literature. , 1993, Circulation.

[65]  S. Syme,et al.  Educational status and blood pressure: the Second National Health and Nutrition Examination Survey, 1976-1980, and the Hispanic Health and Nutrition Examination Survey, 1982-1984. , 1992, American journal of epidemiology.

[66]  S. Fortmann,et al.  Socioeconomic status and health: how education, income, and occupation contribute to risk factors for cardiovascular disease. , 1992, American journal of public health.

[67]  L H Kuller,et al.  Educational attainment and behavioral and biologic risk factors for coronary heart disease in middle-aged women. , 1989, American journal of epidemiology.

[68]  H. Tyroler Socioeconomic Status in the Epidemiology and Treatment of Hypertension , 1989, Hypertension.

[69]  M. Fiore,et al.  Trends in cigarette smoking in the United States. Educational differences are increasing. , 1989 .

[70]  B. Jacobsen,et al.  Risk factors for coronary heart disease and level of education. The Tromsø Heart Study. , 1988, American journal of epidemiology.

[71]  R. Levy,et al.  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. , 1972, Clinical chemistry.

[72]  T. Bojić,et al.  Genetic Polymorphisms of Neurocardiovascular Disorders , 2015 .

[73]  K. Nozaki,et al.  Gene expression profile of the intima and media of experimentally induced cerebral aneurysms in rats by laser-microdissection and microarray techniques. , 2008, International journal of molecular medicine.

[74]  C. Lewis,et al.  Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study. , 2005, Clinical chemistry.

[75]  T. Martin,et al.  Ca(2+)-dependent activator protein for secretion is critical for the fusion of dense-core vesicles with the membrane in calf adrenal chromaffin cells. , 1999, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[76]  Arya M. Sharma,et al.  Association of a human G-protein β3 subunit variant with hypertension , 1998, Nature Genetics.

[77]  Michael R. Green,et al.  Gene Expression , 1993, Progress in Gene Expression.

[78]  R. Cohen,et al.  Psychosocial factors in the natural history of physical activity. , 1991, American journal of preventive medicine.

[79]  J L Kelsey,et al.  The measurement of social class in epidemiology. , 1988, Epidemiologic reviews.

[80]  S B Hulley,et al.  CARDIA: study design, recruitment, and some characteristics of the examined subjects. , 1988, Journal of clinical epidemiology.

[81]  G. Warnick Enzymatic methods for quantification of lipoprotein lipids. , 1986, Methods in enzymology.

[82]  Race, education and prevalence of hypertension. , 1977, American journal of epidemiology.