论文信息 - Stock-based detection of protein oligomeric states in jsPISA

Stock-based detection of protein oligomeric states in jsPISA

A new version of the popular software PISA for the analysis of macromolecular interfaces and identification of biological assemblies (complexes) from macromolecular crystal structures is presented. The new web server jsPISA has a substantially improved user interface, based on modern JavaScript technologies, and also new elements of analysis: assembly stock and interaction radar. The new elements help interpretation of PISA results in difficult and ambiguous cases, for example, when the oligomeric state depends on protein concentration, or when the biologically relevant interaction is weak and cannot be easily discriminated from superficial crystal contacts. jsPISA is maintained by CCP4 at http://www.ccp4.ac.uk/pisa. There are no login requirements for using the server.

Eugene Krissinel | E. Krissinel

[1] J. Thornton,et al. PQS: a protein quaternary structure file server. , 1998, Trends in biochemical sciences.

[2] Jonathan Chaffer,et al. Learning jQuery , 2007 .

[3] K. Henrick,et al. Inference of macromolecular assemblies from crystalline state. , 2007, Journal of molecular biology.

[4] Janet M. Thornton,et al. Automatic inference of protein quaternary structure from crystals , 2003 .

[5] Fabio Nelli. Beginning JavaScript Charts , 2013, Apress.

[6] William R. Smith,et al. Chemical Reaction Equilibrium Analysis: Theory and Algorithms , 1982 .

[7] G. Hong,et al. Nucleic Acids Research , 2015, Nucleic Acids Research.

[8] Sarah A. Teichmann,et al. Principles of protein-protein interactions , 2002, ECCB.

[9] Randy J. Read,et al. Overview of the CCP4 suite and current developments , 2011, Acta crystallographica. Section D, Biological crystallography.

[10] J. Thornton,et al. Discriminating between homodimeric and monomeric proteins in the crystalline state , 2000, Proteins.

[11] Evgeny B. Krissinel,et al. Crystal contacts as nature's docking solutions , 2010, J. Comput. Chem..

[12] J. Sussman,et al. JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia , 2013 .

[13] T. N. Bhat,et al. The Protein Data Bank , 2000, Nucleic Acids Res..