Evidence of α2-Adrenoceptors in the Nasal Blood Vessels of the Dog

• α-Adrenoceptor subtypes were demonstrated in an in vitro preparation of the vascular smooth muscle of the canine nasal mucosa. α1-Receptors were located on the surface of vascular smooth muscle (postsynaptic). α2Subtypes were situated both at postsynaptic and presynaptic sites on adrenergic nerve terminals. Presynaptic α2-adrenoceptor stimulation yielded an inhibition of excessive norepinephrine release from nerve terminals. Stimulation of postsynaptic receptors, either α1or α2, produced vasoconstriction. Although there was good evidence of the presence of postsynaptic α2-receptors, they did not appear to be dominant among the postsynaptic receptors. (Arch Otolaryngol1984;110:647-651)

[1]  R. T. Jackson.  A new in vitro method of drug assay of nasal blood vessels , 2004, Archives of oto-rhino-laryngology.

[2]  K. Starke,et al.  Relative pre- and postsynaptic potencies of α-adrenoceptor agonists in the rabbit pulmonary artery , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[3]  M. Bende.  The effect of topical decongestant on blood flow in normal and infected nasal mucosa. , 1983, Acta oto-laryngologica.

[4]  K. Starke,et al.  Types and Functions of Peripheral α-adrenoceptors , 1982 .

[5]  P. Vanhoutte,et al.  Uneven Distribution of Postjunctional Alphai‐ and Alpha2‐like Adrenoceptors in Canine Arterial and Venous Smooth Muscle , 1981, Circulation research.

[6]  J. Cherry,et al.  Scanning Electron Microscopic Demonstration of Goblet Cell Discharge and Mucous Layer on Nasal Ciliated Respiratory Epithelium , 1980, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[7]  W. Pettinger,et al.  A functional basis for classification of α-adrenergic receptors , 1977 .

[8]  K. Starke.  Regulation of noradrenaline release by presynaptic receptor systems. , 1977, Reviews of physiology, biochemistry and pharmacology.

[9]  S. Z. Langer,et al.  Presynaptic regulation of catecholamine release. , 1974, Biochemical pharmacology.

[10]  M. Dubocovich,et al.  Negative feedback regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre‐ and post‐synaptic adrenergic receptors , 1974, The Journal of physiology.

[11]  R. T. Jackson,et al.  XCI Effects of Alpha and Beta Adrenergic Agonists on Nasal Blood Flow , 1968, The Annals of otology, rhinology, and laryngology.