Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension
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B. Dahal | W. Seeger | J. Stasch | N. Weissmann | F. Grimminger | R. Schermuly | Ying-Ju Lai | D. Kosanovic | A. Sydykov | H. Schirok | R. Kast | H. Ghofrani | P. K. Pamarthi | W. Seeger | H. Ghofrani | Pavan Kumar Pamarthi | F. Grimminger
[1] B. Dahal,et al. Role of epidermal growth factor inhibition in experimental pulmonary hypertension. , 2010, American journal of respiratory and critical care medicine.
[2] H. Fujita,et al. Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. , 2009, Circulation journal : official journal of the Japanese Circulation Society.
[3] B. Dahal,et al. The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice. , 2009, American journal of physiology. Lung cellular and molecular physiology.
[4] Yingling Liu,et al. Serotonin induces Rho/ROCK‐dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[5] N. Weissmann,et al. Cellular and molecular basis of pulmonary arterial hypertension. , 2009, Journal of the American College of Cardiology.
[6] M. Humbert,et al. Future perspectives for the treatment of pulmonary arterial hypertension. , 2009, Journal of the American College of Cardiology.
[7] W. Seeger,et al. The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension. , 2009, American journal of respiratory cell and molecular biology.
[8] X. Zheng,et al. ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells , 2009, Circulation research.
[9] M. Humbert,et al. RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling. , 2009, American journal of respiratory and critical care medicine.
[10] W. Xia,et al. Acute Inhibition of Rho-Kinase Attenuates Pulmonary Hypertension in Patients with Congenital Heart Disease , 2009, Pediatric Cardiology.
[11] J. Stasch,et al. Design and Synthesis of Potent and Selective Azaindole‐Based Rho Kinase (ROCK) Inhibitors , 2008, ChemMedChem.
[12] M. Oka,et al. Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension , 2008, British journal of pharmacology.
[13] M. Humbert,et al. Review: Therapeutic advances in pulmonary arterial hypertension , 2008, Therapeutic advances in respiratory disease.
[14] L. Walker,et al. Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. , 2008, American journal of physiology. Lung cellular and molecular physiology.
[15] P. McNamara,et al. Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide. , 2008, American journal of physiology. Lung cellular and molecular physiology.
[16] 田原 俊介. Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats , 2008 .
[17] A. Zaiman,et al. PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation. , 2008, American journal of physiology. Lung cellular and molecular physiology.
[18] M. Oka,et al. Endothelin-1 and Serotonin are Involved in Activation of RhoA/Rho Kinase Signaling in the Chronically Hypoxic Hypertensive Rat Pulmonary Circulation , 2007, Journal of cardiovascular pharmacology.
[19] J. Stasch,et al. Cardiovascular effects of a novel potent and highly selective azaindole‐based inhibitor of Rho‐kinase , 2007, British journal of pharmacology.
[20] H. Shimokawa,et al. Effects of Combined Therapy With a Rho-Kinase Inhibitor and Prostacyclin on Monocrotaline-Induced Pulmonary Hypertension in Rats , 2007, Journal of cardiovascular pharmacology.
[21] R. Johns,et al. Regression of chronic hypoxic pulmonary hypertension by simvastatin. , 2007, American journal of physiology. Lung cellular and molecular physiology.
[22] W. Seeger,et al. Phosphodiesterase 1 Upregulation in Pulmonary Arterial Hypertension: Target for Reverse-Remodeling Therapy , 2007, Circulation.
[23] N. Voelkel,et al. Rho Kinase-Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats , 2007, Circulation research.
[24] H. Shimokawa,et al. Acute Vasodilator Effect of Fasudil, a Rho-kinase Inhibitor, in Monocrotaline-Induced Pulmonary Hypertension in Rats , 2007, Journal of cardiovascular pharmacology.
[25] Ruopeng Sun,et al. Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats. , 2007, Pharmacological research.
[26] K. Kaibuchi,et al. Long-Term Inhibition of Rho-kinase Ameliorates Hypoxia-Induced Pulmonary Hypertension in Mice , 2006, Journal of cardiovascular pharmacology.
[27] Hiroaki Shimokawa,et al. ROCK Controls Matrix Synthesis in Vascular Smooth Muscle Cells: Coupling Vasoconstriction to Vascular Remodeling , 2006, Circulation research.
[28] K. Morris,et al. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. , 2006, Journal of applied physiology.
[29] P. Pacaud,et al. Rho kinases in cardiovascular physiology and pathophysiology. , 2006, Circulation research.
[30] T. Nakano,et al. Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension. , 2006, Circulation journal : official journal of the Japanese Circulation Society.
[31] H. Hidaka,et al. Development of specific Rho-kinase inhibitors and their clinical application. , 2005, Biochimica et biophysica acta.
[32] P. Pacaud,et al. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension , 2005, British journal of pharmacology.
[33] W. Seeger,et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. , 2005, The Journal of clinical investigation.
[34] P. McLoughlin,et al. Inhibition of Rho-Kinase Attenuates Hypoxia-Induced Angiogenesis in the Pulmonary Circulation , 2005, Circulation research.
[35] H. Shimokawa,et al. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. , 2005, American journal of respiratory and critical care medicine.
[36] A. Takeshita,et al. Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension , 2005, Heart.
[37] K. Morris,et al. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. , 2004, American journal of physiology. Lung cellular and molecular physiology.
[38] M. Humbert,et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. , 2004, Journal of the American College of Cardiology.
[39] K. Kaibuchi,et al. Long-Term Treatment With a Rho-Kinase Inhibitor Improves Monocrotaline-Induced Fatal Pulmonary Hypertension in Rats , 2004, Circulation research.
[40] W. Seeger,et al. Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. , 2004, American journal of respiratory and critical care medicine.
[41] A. Hall,et al. Rho GTPases in cell biology , 2002, Nature.
[42] A. Takeshita,et al. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[43] H. Hidaka,et al. H-series protein kinase inhibitors and potential clinical applications. , 1999, Pharmacology & therapeutics.
[44] H. Nagumo,et al. HA1077, a protein kinase inhibitor, inhibits calponin phosphorylation on Ser175 in porcine coronary artery. , 1998, European journal of pharmacology.
[45] Yasuharu Sasaki,et al. A Protein Kinase Inhibitor, Fasudil (AT‐877): A Novel Approach to Signal Transduction Therapy , 1998 .
[46] Shuh Narumiya,et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension , 1997, Nature.
[47] K. Nakao,et al. ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice , 1996, FEBS letters.
[48] T. Yamamoto,et al. Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. , 1996, The EMBO journal.
[49] L. Lim,et al. A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes (*) , 1995, The Journal of Biological Chemistry.