Gambling disorder and other behavioral addictions: recognition and treatment.

Addiction professionals and the public are recognizing that certain nonsubstance behaviors--such as gambling, Internet use, video-game playing, sex, eating, and shopping--bear resemblance to alcohol and drug dependence. Growing evidence suggests that these behaviors warrant consideration as nonsubstance or "behavioral" addictions and has led to the newly introduced diagnostic category "Substance-Related and Addictive Disorders" in DSM-5. At present, only gambling disorder has been placed in this category, with insufficient data for other proposed behavioral addictions to justify their inclusion. This review summarizes recent advances in our understanding of behavioral addictions, describes treatment considerations, and addresses future directions. Current evidence points to overlaps between behavioral and substance-related addictions in phenomenology, epidemiology, comorbidity, neurobiological mechanisms, genetic contributions, responses to treatments, and prevention efforts. Differences also exist. Recognizing behavioral addictions and developing appropriate diagnostic criteria are important in order to increase awareness of these disorders and to further prevention and treatment strategies.

[1]  Alan A. Wilson,et al.  In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [11C]-(+)-PHNO , 2014, Molecular Psychiatry.

[2]  M. Potenza The neural bases of cognitive processes in gambling disorder , 2014, Trends in Cognitive Sciences.

[3]  Nerilee Hing,et al.  Professional Help-Seeking for Gambling Problems: Awareness, Barriers and Motivators for Treatment , 2014, Journal of Gambling Studies.

[4]  R. Rogers,et al.  A Selective Role for Dopamine D4 Receptors in Modulating Reward Expectancy in a Rodent Slot Machine Task , 2014, Biological Psychiatry.

[5]  M. Potenza,et al.  Treatment of Gambling Disorders , 2014, Current Treatment Options in Psychiatry.

[6]  M. Potenza,et al.  Addictions and Personality Traits: Impulsivity and Related Constructs , 2014, Current Behavioral Neuroscience Reports.

[7]  M. Potenza,et al.  Hippocampal and Amygdalar Volumetric Differences in Pathological Gambling: a Preliminary Study of the Associations with the Behavioral Inhibition System , 2014, Neuropsychopharmacology.

[8]  Dan J Stein,et al.  New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity , 2014, CNS Spectrums.

[9]  M. Potenza How central is dopamine to pathological gambling or gambling disorder? , 2013, Front. Behav. Neurosci..

[10]  M. Potenza,et al.  Gender differences in the relationship between gambling problems and the incidence of substance-use disorders in a nationally representative population sample. , 2013, Drug and alcohol dependence.

[11]  M. Potenza,et al.  Increased Incidence of Cardiovascular Conditions Among Older Adults With Pathological Gambling Features in a Prospective Study , 2013, Journal of addiction medicine.

[12]  N. Martin,et al.  Genome‐wide association study of a quantitative disordered gambling trait , 2013, Addiction biology.

[13]  L. Schreiber,et al.  Phenomenology and Treatment of Behavioural Addictions , 2013, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[14]  M. Potenza,et al.  A Targeted Review of the Neurobiology and Genetics of Behavioural Addictions: An Emerging Area of Research , 2013, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[15]  Alan A. Wilson,et al.  The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride. , 2013, Addiction.

[16]  M. Potenza,et al.  Neurobiological considerations in understanding behavioral treatments for pathological gambling. , 2013, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[17]  Jarrod M. Ellingson,et al.  Shared Genetic Vulnerability for Disordered Gambling and Alcohol Use Disorder in Men and Women: Evidence from a National Community-Based Australian Twin Study , 2013, Twin Research and Human Genetics.

[18]  R. Fulbright,et al.  Reduced genual corpus callosal white matter integrity in pathological gambling and its relationship to alcohol abuse or dependence , 2013, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[19]  E. Hollander,et al.  A double-blind, placebo-controlled trial of topiramate for pathological gambling , 2013, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[20]  J. Ropchan,et al.  Serotonin 1B receptor imaging in pathological gambling , 2013, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[21]  B. Goodyear,et al.  Neural Correlates of Pathological Gamblers Preference for Immediate Rewards During the Iowa Gambling Task: An fMRI Study , 2012, Journal of Gambling Studies.

[22]  P. Vezina,et al.  On Cue: Striatal Ups and Downs in Addictions , 2012, Biological Psychiatry.

[23]  A. Jackson,et al.  Psychological therapies for pathological and problem gambling. , 2012, The Cochrane database of systematic reviews.

[24]  David J. Nutt,et al.  Striatal dopamine D2/D3 receptor binding in pathological gambling is correlated with mood-related impulsivity , 2012, NeuroImage.

[25]  J. Zohar,et al.  Compulsive features in behavioural addictions: the case of pathological gambling. , 2012, Addiction.

[26]  J. Kwon,et al.  Altered Brain Activity during Reward Anticipation in Pathological Gambling and Obsessive-Compulsive Disorder , 2012, PloS one.

[27]  Michael J Crowley,et al.  Are Internet use and video-game-playing addictive behaviors? Biological, clinical and public health implications for youths and adults. , 2012, Minerva psichiatrica.

[28]  M. Potenza,et al.  Impulse control disorders in Parkinson's disease: background and update on prevention and management. , 2012, Neurodegenerative disease management.

[29]  W. van den Brink,et al.  A voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls. , 2012, Drug and alcohol dependence.

[30]  G. Andersson,et al.  Internet-Based Treatment of Pathological Gambling with a Three-Year Follow-Up , 2012, Cognitive behaviour therapy.

[31]  Shahrzad Mazhari,et al.  Association Between Problematic Internet Use and Impulse Control Disorders Among Iranian University Students , 2012, Cyberpsychology Behav. Soc. Netw..

[32]  Jarkko Johansson,et al.  Mesolimbic dopamine release is linked to symptom severity in pathological gambling , 2012, NeuroImage.

[33]  J. R.,et al.  Imaging studies in pathological gambling: similarities and differences with alcohol dependence , 2011 .

[34]  G. Pearlson,et al.  Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling , 2012, Biological Psychiatry.

[35]  Guy B. Williams,et al.  Abnormal Brain Structure Implicated in Stimulant Drug Addiction , 2012, Science.

[36]  L. Becerra,et al.  Yohimbine-Induced Amygdala Activation in Pathological Gamblers: A Pilot Study , 2012, PloS one.

[37]  N. Petry Discounting of probabilistic rewards is associated with gambling abstinence in treatment-seeking pathological gamblers. , 2012, Journal of abnormal psychology.

[38]  M. Potenza,et al.  Pathological Gambling: Neuropsychopharmacology and Treatment. , 2012, Current psychopharmacology.

[39]  H. Lei,et al.  Abnormal White Matter Integrity in Adolescents with Internet Addiction Disorder: A Tract-Based Spatial Statistics Study , 2012, PloS one.

[40]  Reef Karim,et al.  Behavioral Addictions: An Overview , 2012, Journal of psychoactive drugs.

[41]  R. Parkkola,et al.  Extensive abnormality of brain white matter integrity in pathological gambling , 2011, Psychiatry Research: Neuroimaging.

[42]  B. Hoebel,et al.  Rats that binge eat fat-rich food do not show somatic signs or anxiety associated with opiate-like withdrawal: Implications for nutrient-specific food addiction behaviors , 2011, Physiology & Behavior.

[43]  C. Blanco,et al.  Gambling, disordered gambling and their association with major depression and substance use: a web-based cohort and twin-sibling study , 2011, Psychological Medicine.

[44]  Debi A. LaPlante,et al.  Disordered gambling, type of gambling and gambling involvement in the British Gambling Prevalence Survey 2007. , 2011, European journal of public health.

[45]  Eric Stice,et al.  Neural correlates of food addiction. , 2011, Archives of general psychiatry.

[46]  C. Elger,et al.  A Neurological Study of Compulsive Buying Behaviour , 2011 .

[47]  Sang Hee Kim,et al.  Reduced striatal dopamine D2 receptors in people with Internet addiction , 2011, Neuroreport.

[48]  Jie Tian,et al.  Microstructure Abnormalities in Adolescents with Internet Addiction Disorder , 2011, PloS one.

[49]  T. Afifi,et al.  Disordered (pathologic or problem) gambling and axis I psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. , 2011, American journal of epidemiology.

[50]  A. Lang,et al.  Impulse control disorders in parkinson disease: A multicenter case–control study , 2011, Annals of neurology.

[51]  Suck-Won Kim,et al.  A neurocognitive comparison of cognitive flexibility and response inhibition in gamblers with varying degrees of clinical severity , 2011, Psychological Medicine.

[52]  S. Cowlishaw,et al.  Prevalence of comorbid disorders in problem and pathological gambling: systematic review and meta-analysis of population surveys. , 2011, Addiction.

[53]  Arne Møller,et al.  Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling. , 2011, Addiction.

[54]  A. Gjedde,et al.  Inverse association between dopaminergic neurotransmission and Iowa Gambling Task performance in pathological gamblers and healthy controls. , 2011, Scandinavian journal of psychology.

[55]  D. Gentile,et al.  Pathological Video Game Use Among Youths: A Two-Year Longitudinal Study , 2011, Pediatrics.

[56]  D. Hommer,et al.  Imaging brain response to reward in addictive disorders , 2011, Annals of the New York Academy of Sciences.

[57]  Ana P. Gantman,et al.  Decreased neuronal activity in reward circuitry of pathological gamblers during processing of personal relevant stimuli , 2010, Human brain mapping.

[58]  Dick J Veltman,et al.  Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study , 2010, Addiction biology.

[59]  E. Hollander,et al.  Nalmefene in the treatment of pathological gambling: multicentre, double-blind, placebo-controlled study , 2010, British Journal of Psychiatry.

[60]  J. Kennedy,et al.  Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects , 2010, Biological Psychology.

[61]  M. Brown,et al.  Commonalities in the Psychological Factors Associated with Problem Gambling and Internet Dependence , 2010, Cyberpsychology Behav. Soc. Netw..

[62]  D. Tolin Is cognitive-behavioral therapy more effective than other therapies? A meta-analytic review. , 2010, Clinical psychology review.

[63]  M. Potenza,et al.  Pathological Gambling and Substance Use Disorders , 2010, The American journal of drug and alcohol abuse.

[64]  A. Weinstein,et al.  Computer and Video Game Addiction—A Comparison between Game Users and Non-Game Users , 2010, The American journal of drug and alcohol abuse.

[65]  N. Martin,et al.  Genetic and environmental influences on disordered gambling in men and women. , 2010, Archives of general psychiatry.

[66]  E. Hollander,et al.  Noradrenergic function in pathological gambling: blunted growth hormone response to clonidine , 2010, Journal of psychopharmacology.

[67]  A. Lang,et al.  Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. , 2010, Archives of neurology.

[68]  P. Kenny,et al.  Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats , 2010, Nature Neuroscience.

[69]  C. Holden Psychiatry. Behavioral addictions debut in proposed DSM-V. , 2010, Science.

[70]  J. Grant,et al.  Motor inhibition and cognitive flexibility in pathologic skin picking , 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[71]  Edward T Bullmore,et al.  Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review , 2010, Neuropsychopharmacology.

[72]  L. Brown,et al.  Shared brain vulnerabilities open the way for nonsubstance addictions: Carving addiction at a new joint? , 2010, Annals of the New York Academy of Sciences.

[73]  C. Ko,et al.  The characteristics of decision making, potential to take risks, and personality of college students with Internet addiction , 2010, Psychiatry Research.

[74]  K. Lim,et al.  Preliminary investigation of the impulsive and neuroanatomical characteristics of compulsive sexual behavior , 2009, Psychiatry Research: Neuroimaging.

[75]  L. Koran,et al.  The relationship between impulse-control disorders and obsessive–compulsive disorder: A current understanding and future research directions , 2009, Psychiatry Research.

[76]  A. Blaszczynski,et al.  Sex Differences in the Rates of Recovery, Treatment-Seeking, and Natural Recovery in Pathological Gambling: Results From an Australian Community-Based Twin Survey , 2009, Twin Research and Human Genetics.

[77]  J. Kennedy,et al.  Genetic aspects of pathological gambling: a complex disorder with shared genetic vulnerabilities. , 2009, Addiction.

[78]  Chih-Hung Ko,et al.  Proposed diagnostic criteria and the screening and diagnosing tool of Internet addiction in college students. , 2009, Comprehensive psychiatry.

[79]  B. Sahakian,et al.  Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals , 2009, Addiction.

[80]  C. Ko,et al.  Brain activities associated with gaming urge of online gaming addiction. , 2009, Journal of psychiatric research.

[81]  C. Ko,et al.  The association between harmful alcohol use and Internet addiction among college students: Comparison of personality , 2009, Psychiatry and clinical neurosciences.

[82]  B. Hoebel,et al.  Sugar and fat bingeing have notable differences in addictive-like behavior. , 2009, The Journal of nutrition.

[83]  Marie-Cecile O. Tidwell,et al.  The association of form of gambling with problem gambling among American youth. , 2009, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[84]  N. Volkow,et al.  Imaging of Brain Dopamine Pathways: Implications for Understanding Obesity , 2009, Journal of addiction medicine.

[85]  L. Clark,et al.  Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies , 2008, Neuroscience & Biobehavioral Reviews.

[86]  T. Oei,et al.  The current status and future direction of self-help treatments for problem gamblers. , 2008, Clinical psychology review.

[87]  M. Potenza,et al.  The neurobiology of pathological gambling and drug addiction: an overview and new findings , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[88]  E. Pothos,et al.  Evidence for defective mesolimbic dopamine exocytosis in obesity‐prone rats , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[89]  Adam Johnson,et al.  Computing motivation: Incentive salience boosts of drug or appetite states , 2008, Behavioral and Brain Sciences.

[90]  P. Renshaw,et al.  Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users. , 2008, Journal of affective disorders.

[91]  E. Hollander,et al.  Predicting response to opiate antagonists and placebo in the treatment of pathological gambling , 2008, Psychopharmacology.

[92]  B. Hoebel,et al.  After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance , 2008, Physiology & Behavior.

[93]  B. K. Hartman,et al.  A double-blind, placebo-controlled study of the opiate antagonist naltrexone in the treatment of pathological gambling urges. , 2008, The Journal of clinical psychiatry.

[94]  R. Rosenthal,et al.  A double-blind, placebo-controlled trial of olanzapine for the treatment of video poker pathological gamblers , 2008, Pharmacology Biochemistry and Behavior.

[95]  Eric Hollander,et al.  Escitalopram in the treatment of impulsive-compulsive internet usage disorder: an open-label trial followed by a double-blind discontinuation phase. , 2008, The Journal of clinical psychiatry.

[96]  P. Keck,et al.  Olanzapine in the treatment of pathological gambling: a negative randomized placebo-controlled trial. , 2008, The Journal of clinical psychiatry.

[97]  J. Brewer,et al.  The Treatment of Pathologic Gambling , 2008 .

[98]  K C Winters,et al.  DSM-IV pathological gambling in the National Comorbidity Survey Replication , 2008, Psychological Medicine.

[99]  Debi A. LaPlante,et al.  Stability and Progression of Disordered Gambling: Lessons from Longitudinal Studies , 2008, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[100]  W. Bickel,et al.  A scale-free systems theory of motivation and addiction , 2007, Neuroscience & Biobehavioral Reviews.

[101]  E. Claus,et al.  Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision‐making , 2007, Human brain mapping.

[102]  P. Dannon,et al.  12-Month Follow-Up Study of Drug Treatment in Pathological Gamblers: A Primary Outcome Study , 2007, Journal of clinical psychopharmacology.

[103]  Kimberly Young,et al.  Cognitive Behavior Therapy with Internet Addicts: Treatment Outcomes and Implications , 2007, Cyberpsychology Behav. Soc. Netw..

[104]  Suck-Won Kim,et al.  N-Acetyl Cysteine, a Glutamate-Modulating Agent, in the Treatment of Pathological Gambling: A Pilot Study , 2007, Biological Psychiatry.

[105]  P. Renshaw,et al.  Dopamine Genes and Reward Dependence in Adolescents with Excessive Internet Video Game Play , 2007, Journal of addiction medicine.

[106]  D. Black,et al.  The Effect of Pathological Gambling on Families, Marriages, and Children , 2007, CNS Spectrums.

[107]  W. van den Brink,et al.  The role of self-reported impulsivity and reward sensitivity versus neurocognitive measures of disinhibition and decision-making in the prediction of relapse in pathological gamblers , 2007, Psychological Medicine.

[108]  Jeffrey N. Jonkman,et al.  Disordered Gambling among College Students: A Meta-Analytic Synthesis , 2007, Journal of Gambling Studies.

[109]  Brian Knutson,et al.  Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics , 2007, NeuroImage.

[110]  M. Zack,et al.  A D2 Antagonist Enhances the Rewarding and Priming Effects of a Gambling Episode in Pathological Gamblers , 2007, Neuropsychopharmacology.

[111]  E. Hollander,et al.  A double-blind study of citalopram versus placebo in the treatment of compulsive sexual behaviors in gay and bisexual men. , 2006, The Journal of clinical psychiatry.

[112]  Xin Huang,et al.  Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity , 2006, Behavioural Brain Research.

[113]  B. Reynolds A review of delay-discounting research with humans: relations to drug use and gambling , 2006, Behavioural pharmacology.

[114]  M. Potenza Should addictive disorders include non-substance-related conditions? , 2006, Addiction.

[115]  N. Petry,et al.  Cognitive-behavioral therapy for pathological gamblers. , 2006, Journal of consulting and clinical psychology.

[116]  D. Black,et al.  A family study of pathological gambling , 2006, Psychiatry Research.

[117]  E. Hollander,et al.  Multicenter investigation of the opioid antagonist nalmefene in the treatment of pathological gambling. , 2006, The American journal of psychiatry.

[118]  W. Slutske Natural recovery and treatment-seeking in pathological gambling: results of two U.S. national surveys. , 2006, The American journal of psychiatry.

[119]  Jodi D. Edwards,et al.  Cue-Induced Brain Activity in Pathological Gamblers , 2005, Biological Psychiatry.

[120]  E. Butelman,et al.  Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction , 2005, Nature Neuroscience.

[121]  T. Robbins,et al.  Neural systems of reinforcement for drug addiction: from actions to habits to compulsion , 2005, Nature Neuroscience.

[122]  S. Pallesen,et al.  Outcome of psychological treatments of pathological gambling: a review and meta-analysis. , 2005, Addiction.

[123]  J. Cunningham Little use of treatment among problem gamblers. , 2005, Psychiatric services.

[124]  Hermano Tavares,et al.  Comparison of craving between pathological gamblers and alcoholics. , 2005, Alcoholism, clinical and experimental research.

[125]  R. Velleman,et al.  Family interventions in the treatment of alcohol and drug problems. , 2005, Drug and alcohol review.

[126]  N. Petry,et al.  Childhood maltreatment in male and female treatment-seeking pathological gamblers. , 2005, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[127]  B. Grant,et al.  Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. , 2005, The Journal of clinical psychiatry.

[128]  Wim van den Brink,et al.  Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. , 2005, Brain research. Cognitive brain research.

[129]  J. Gläscher,et al.  Pathological gambling is linked to reduced activation of the mesolimbic reward system , 2005, Nature Neuroscience.

[130]  M. Schedlowski,et al.  Neuroendocrine response to casino gambling in problem gamblers , 2004, Psychoneuroendocrinology.

[131]  Debi A. LaPlante,et al.  Toward a Syndrome Model of Addiction: Multiple Expressions, Common Etiology , 2004, Harvard review of psychiatry.

[132]  S. Currie,et al.  Brief motivational treatment for problem gambling: a 24-month follow-up. , 2004, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[133]  H. Sumnall,et al.  Self-Reported Psychopathology in Polydrug Users , 2004, Journal of psychopharmacology.

[134]  J. Grant Three cases of compulsive buying treated with naltrexone , 2003 .

[135]  N. Petry Patterns and correlates of Gamblers Anonymous attendance in pathological gamblers seeking professional treatment. , 2003, Addictive behaviors.

[136]  John C Gore,et al.  Gambling urges in pathological gambling: a functional magnetic resonance imaging study. , 2003, Archives of general psychiatry.

[137]  J. Hektner,et al.  Paroxetine treatment of pathological gambling: a multi-centre randomized controlled trial. , 2003 .

[138]  D. Oslin,et al.  A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients , 2003, Neuropsychopharmacology.

[139]  JaneR . Taylor,et al.  Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. , 2003, The American journal of psychiatry.

[140]  Kenneth J Sher,et al.  The natural history of problem gambling from age 18 to 29. , 2003, Journal of abnormal psychology.

[141]  Suck-Won Kim,et al.  A double-blind placebo-controlled study of the efficacy and safety of paroxetine in the treatment of pathological gambling. , 2002, The Journal of clinical psychiatry.

[142]  B. Hoebel,et al.  Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. , 2002, Obesity research.

[143]  A. Blaszczynski,et al.  A pathways model of problem and pathological gambling. , 2002, Addiction.

[144]  C. Blanco,et al.  A Pilot Placebo-Controlled Study of Fluvoxamine for Pathological Gambling , 2002, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[145]  R. Rosenheck,et al.  Naltrexone in the treatment of alcohol dependence. , 2001, The New England journal of medicine.

[146]  J. Grant,et al.  A Case of Kleptomania and Compulsive Sexual Behavior Treated with Naltrexone , 2001, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[147]  J S Fowler,et al.  Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. , 2001, The American journal of psychiatry.

[148]  Eric B. Weiser,et al.  The Functions of Internet Use and Their Social and Psychological Consequences , 2001, Cyberpsychology Behav. Soc. Netw..

[149]  Suck-Won Kim,et al.  Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling , 2001, Biological Psychiatry.

[150]  E. Hollander,et al.  A randomized double-blind fluvoxamine/placebo crossover trial in pathologic gambling , 2000, Biological Psychiatry.

[151]  D. Desmond,et al.  Addiction or dependence? , 2000, Addiction.

[152]  C. Nordin,et al.  Altered CSF 5-HIAA Disposition in Pathologic Male Gamblers , 1999, CNS Spectrums.

[153]  J. Vander Bilt,et al.  Estimating the prevalence of disordered gambling behavior in the United States and Canada: a research synthesis. , 1999, American journal of public health.

[154]  J. Fernández-Piqueras,et al.  Genetic contribution to pathological gambling: possible association between a functional DNA polymorphism at the serotonin transporter gene (5-HTT) and affected men. , 1999, Pharmacogenetics.

[155]  D. Comings,et al.  A study of the dopamine D2 receptor gene in pathological gambling. , 1996, Pharmacogenetics.

[156]  J. Schneider,et al.  Couple recovery from sexual addiction / co addiction: Results of a survey of 88 marriages , 1996 .

[157]  C. O'brien,et al.  Myths about the treatment of addiction , 1996, The Lancet.

[158]  Jean Logan,et al.  Imaging endogenous dopamine competition with [11C]raclopride in the human brain , 1994, Synapse.

[159]  R. Bland,et al.  Epidemiology of Pathological Gambling in Edmonton * , 1993, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[160]  G. Sedvall,et al.  Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. , 1992, Archives of general psychiatry.

[161]  Christopher B. Donahue,et al.  A randomized, placebo-controlled trial of N-acetylcysteine plus imaginal desensitization for nicotine-dependent pathological gamblers. , 2014, The Journal of clinical psychiatry.

[162]  M. Potenza Non-substance addictive behaviors in the context of DSM-5. , 2014, Addictive behaviors.

[163]  J. A. Johnson,et al.  Use of AUDIT-based measures to identify unhealthy alcohol use and alcohol dependence in primary care: a validation study. , 2013, Alcoholism, clinical and experimental research.

[164]  M. Potenza,et al.  Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity , 2011, Psychopharmacology.

[165]  R. Volberg,et al.  An international perspective on youth gambling prevalence studies. , 2010, International journal of adolescent medicine and health.

[166]  N. Volkow,et al.  Neurocircuitry of Addiction , 2010, Neuropsychopharmacology.

[167]  H. Lesieur,et al.  The South Oaks Gambling Screen (SaGS): A New Instrument for the Identification of Pathological Gamblers , 2010 .

[168]  J. Xiao,et al.  Buying behavior, social support and credit card indebtedness of college students , 2009 .

[169]  J. Brewer,et al.  The neurobiology and genetics of impulse control disorders: relationships to drug addictions. , 2008, Biochemical pharmacology.

[170]  Dimitris Samaras,et al.  Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction? , 2007, The American journal of psychiatry.

[171]  H. Xian,et al.  Genetic Studies of Pathological Gambling: A Review of Methodology and Analyses of Data from the Vietnam Era Twin Registry , 2005, Journal of Gambling Studies.

[172]  N. Petry Gamblers Anonymous and Cognitive-Behavioral Therapies for Pathological Gamblers , 2004, Journal of Gambling Studies.

[173]  M. Zack,et al.  Amphetamine Primes Motivation to Gamble and Gambling-Related Semantic Networks in Problem Gamblers , 2004, Neuropsychopharmacology.

[174]  Suck-Won Kim,et al.  Treatment of compulsive sexual behaviour with naltrexone and serotonin reuptake inhibitors: two case studies. , 2002, International clinical psychopharmacology.

[175]  J. Fernández-Piqueras,et al.  Concurrent positive association between pathological gambling and functional DNA polymorphisms at the MAO-A and the 5-HT transporter genes , 2002, Molecular Psychiatry.

[176]  C. Blanco,et al.  Pathological gambling and DNA polymorphic markers at MAO-A and MAO-B genes , 2000, Molecular Psychiatry.

[177]  E. OchoaMangado Naltrexone in the treatment of alcohol dependence , 1998 .

[178]  Cheryl M. Wong,et al.  Obsessive-compulsive spectrum disorders. , 1995, The Journal of clinical psychiatry.

[179]  J M Smith,et al.  Compulsive buying: a report of 20 cases. , 1994, The Journal of clinical psychiatry.