Stereotaxic implantation of 5‐fluorouracil‐releasing microspheres in malignant glioma

The authors developed a new method of drug delivery into the brain using implantable, biodegradable microspheres. The strategy was evaluated initially to provide localized and sustained delivery of the radiosensitizer 5‐fluorouracil (5‐FU) after patients underwent surgical resection of malignant glioma. In this study, the microspheres were implanted by stereotaxy into deeply situated and inoperable brain tumors.

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