Reduced levels of human apoE4 protein in an animal model of cognitive impairment
暂无分享,去创建一个
K. Bales | B. Mace | J. Ervin | B. Han | P. Sullivan | F. Liu | S. Wu | D. Koger | S. Paul | F. Liu | Patrick Sullivan | Feng Liu | Brian E. Mace | John F. Ervin | Su Wu | Steven M. Paul
[1] M. Pangalos,et al. Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels , 2008, The Journal of Neuroscience.
[2] S. Paul,et al. Liver X Receptor-Mediated Gene Regulation and Cholesterol Homeostasis in Brain: Relevance to Alzheimers Disease Therapeutics , 2007 .
[3] J. Raber,et al. Sex- and APOE Isoform-Dependent Effects of Radiation on Cognitive Function , 2006, Radiation research.
[4] M. Hayden,et al. The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease* , 2005, Journal of Biological Chemistry.
[5] K. Weisgraber,et al. Effect of Domain Interaction on Apolipoprotein E Levels in Mouse Brain , 2005, The Journal of Neuroscience.
[6] A. Fagan,et al. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β , 2005, Neurobiology of Disease.
[7] C. Kelche,et al. Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior , 2005, Behavioural Brain Research.
[8] D. Holtzman,et al. Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model , 2005, The Journal of Neuroscience.
[9] S. D. Moore,et al. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology , 2005, Neurobiology of Disease.
[10] Judes Poirier,et al. Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease , 2005, Neurobiology of Aging.
[11] G. Gamkrelidze,et al. ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-β1–42 , 2005, Neurobiology of Disease.
[12] D. Schmechel,et al. Marked regional differences of brain human apolipoprotein e expression in targeted replacement mice , 2004, Neuroscience.
[13] Sung Hwan Yun,et al. ApoE isoform affects LTP in human targeted replacement mice , 2004, Neuroreport.
[14] CL. Wellington,et al. Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism , 2004, Clinical genetics.
[15] S. Paul,et al. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes , 2004, Journal of neurochemistry.
[16] L. Lanningham-Foster,et al. Harmful Effects of Increased LDLR Expression in Mice With Human APOE*4 But Not APOE*3 , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[17] B. Rupp,et al. Apolipoprotein E4 Forms a Molten Globule , 2002, The Journal of Biological Chemistry.
[18] D. Holtzman,et al. Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease , 2002, Journal of neurochemistry.
[19] Johnm . Taylor,et al. Two Distal Downstream Enhancers Direct Expression of the Human Apolipoprotein E Gene to Astrocytes in the Brain , 2001, The Journal of Neuroscience.
[20] B. Hyman,et al. Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APPV717F transgenic mice , 2000, Acta Neuropathologica.
[21] B. Rupp,et al. Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain. , 2000, Biochemistry.
[22] Kaj Blennow,et al. Measurement of Apolipoprotein E (apoE) in Cerebrospinal Fluid , 2000, Neurochemical Research.
[23] A. Fagan,et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[24] Charles Ramassamy,et al. Apolipoprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent , 1999, Brain Research.
[25] Masahiko Watanabe,et al. Apo E structure determines VLDL clearance and atherosclerosis risk in mice. , 1999, The Journal of clinical investigation.
[26] D. Easton,et al. Apolipoprotein E Genetic Variation and Alzheimer’s Disease , 1999, Dementia and Geriatric Cognitive Disorders.
[27] A. Fagan,et al. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. , 1999, The Journal of clinical investigation.
[28] N. Maeda,et al. Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. , 1998, The Journal of clinical investigation.
[29] A. Hofman,et al. Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study , 1998, Neuroscience Letters.
[30] S. Paul,et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition , 1997, Nature Genetics.
[31] N. Maeda,et al. Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis* , 1997, The Journal of Biological Chemistry.
[32] Thomas Arendt,et al. Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer’s Disease Carrying Apolipoprotein ε4 Allele , 1997, The Journal of Neuroscience.
[33] G. Siest,et al. Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors. , 1996, Journal of lipid research.
[34] T. Lehtimäki,et al. Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls , 1996, Brain Research.
[35] C. Finch,et al. Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease. , 1995, Brain research. Molecular brain research.
[36] J. Poirier. Apolipoprotein E in animal models of CNS injury and in alzheimer's disease , 1994, Trends in Neurosciences.
[37] E. Masliah,et al. Synaptic and neuritic alterations during the progression of Alzheimer's disease , 1994, Neuroscience Letters.
[38] S. Gauthier,et al. Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats , 1993, Neuroscience.
[39] N. Maeda,et al. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. , 1992, Science.
[40] D. T. Vernier,et al. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. , 1990, Journal of lipid research.
[41] R. Gregg,et al. Abnormal in vivo metabolism of apolipoprotein E4 in humans. , 1986, The Journal of clinical investigation.
[42] G. Utermann,et al. Genetics of the apolipoprotein E system in man. , 1980, American journal of human genetics.
[43] L. Iversen,et al. REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I , 1966, Journal of neurochemistry.
[44] A. D. Roses,et al. Association of apolipoprotein E allele €4 with late-onset familial and sporadic Alzheimer’s disease , 2006 .
[45] C. Sing,et al. Apolipoprotein E polymorphism and atherosclerosis. , 1988, Arteriosclerosis.
[46] Edu,et al. Molecular Neurodegeneration Apolipoprotein E Levels in Cerebrospinal Fluid and the Effects of Abca1 Polymorphisms , 2022 .