ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK).
暂无分享,去创建一个
[1] J. Mendelsohn,et al. Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma , 1993, Cancer Immunology, Immunotherapy.
[2] C. Denkert,et al. An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells , 2004, Clinical & Experimental Metastasis.
[3] S. Salzano,et al. The Cleavage of the Urokinase Receptor Regulates Its Multiple Functions* , 2002, The Journal of Biological Chemistry.
[4] J. Brenton,et al. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. , 2002, Cancer research.
[5] C. Der,et al. Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation* , 2002, The Journal of Biological Chemistry.
[6] L. Ossowski,et al. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. , 2002, Cancer cell.
[7] Albert J. Fornace,et al. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity , 2002, Nature Genetics.
[8] Shuang Huang,et al. Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence , 2002, Molecular and Cellular Biology.
[9] J. Aguirre Ghiso. Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo , 2002, Oncogene.
[10] K. Hahn,et al. Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. , 2002, Nature Reviews Molecular Cell Biology.
[11] J. Kreidberg,et al. Urokinase Receptors Promote β1 Integrin Function through Interactions with Integrin α3β1 , 2001 .
[12] G. Naumov,et al. Solitary cancer cells as a possible source of tumour dormancy? , 2001, Seminars in cancer biology.
[13] W. Falk,et al. A primary tumor promotes dormancy of solitary tumor cells before inhibiting angiogenesis. , 2001, Cancer research.
[14] J. Westwick,et al. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. , 2001, Molecular cell.
[15] S. Itoh,et al. CHOP, a basic leucine zipper transcriptional factor, contributes to the antiproliferative effect of IL-1 on A375 human melanoma cells through augmenting transcription of IL-6. , 2001, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
[16] J. Aguirre-Ghiso,et al. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. , 2001, Molecular biology of the cell.
[17] A. Hall,et al. Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin , 2001, The Journal of cell biology.
[18] S. Pelech,et al. Stress-induced Inhibition of ERK1 and ERK2 by Direct Interaction with p38 MAP Kinase* , 2001, The Journal of Biological Chemistry.
[19] C. Kahn,et al. Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23. , 2001, Cancer research.
[20] Jiahuai Han,et al. The p38 Pathway Provides Negative Feedback for Ras Proliferative Signaling* , 2000, The Journal of Biological Chemistry.
[21] U. Brinck,et al. Comparative study of the expression of DNA mismatch repair genes, the adenomatous polyposis coli gene and growth arrest DNA damage genes in melanoma recurrences and metastases , 2000, Melanoma research.
[22] D. Gillespie,et al. Transient deactivation of ERK signalling is sufficient for stable entry into G0 in primary avian fibroblasts , 2000, Current Biology.
[23] G. Naumov,et al. Molecular biology of breast cancer metastasis: Clinical implications of experimental studies on metastatic inefficiency , 2000, Breast Cancer Research.
[24] G. Nemerow,et al. Urokinase Plasminogen Activator/Urokinase-specific Surface Receptor Expression and Matrix Invasion by Breast Cancer Cells Requires Constitutive p38α Mitogen-activated Protein Kinase Activity* , 2000, The Journal of Biological Chemistry.
[25] S. Rosenberg,et al. Identification of a Urokinase Receptor-Integrin Interaction Site , 2000, The Journal of Biological Chemistry.
[26] Richard T. Lee,et al. Direct Extracellular Contact between Integrin α3β1 and TM4SF Protein CD151* , 2000, The Journal of Biological Chemistry.
[27] Jiahuai Han,et al. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. , 2000, Genes & development.
[28] P. Roux,et al. Differential Effect of Rac and Cdc42 on p38 Kinase Activity and Cell Cycle Progression of Nonadherent Primary Mouse Fibroblasts* , 2000, The Journal of Biological Chemistry.
[29] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[30] U. Brinck,et al. Loss of growth arrest DNA damage genes expression in oral melanomas. , 1999, In vivo.
[31] L. Ossowski,et al. Tumor Dormancy Induced by Downregulation of Urokinase Receptor in Human Carcinoma Involves Integrin and MAPK Signaling , 1999, The Journal of cell biology.
[32] J. M. Lin,et al. Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis. , 1999, Cancer research.
[33] G. Kapoor,et al. One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade. , 1999, The Journal of biological chemistry.
[34] Alan R. Saltiel,et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo , 1999, Nature Medicine.
[35] G. Yancopoulos,et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. , 1999, Science.
[36] S. Matsufuji,et al. Antiproliferative effect of IL-1 is mediated by p38 mitogen-activated protein kinase in human melanoma cell A375. , 1999, Journal of immunology.
[37] H. Ellinger-Ziegelbauer,et al. Cell Cycle Arrest and Reversion of Ras-Induced Transformation by a Conditionally Activated Form of Mitogen-Activated Protein Kinase Kinase Kinase 3 , 1999, Molecular and Cellular Biology.
[38] H. Chapman,et al. A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling , 1999, The Journal of cell biology.
[39] S. Zhuo,et al. Urokinase receptor antagonists: discovery and application to in vivo models of tumor growth , 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
[40] Takashi Tsuruo,et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors , 1999, Oncogene.
[41] Jiahuai Han,et al. Regulation of the MEF2 Family of Transcription Factors by p38 , 1999, Molecular and Cellular Biology.
[42] Jiahuai Han,et al. p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2. , 1998, Circulation research.
[43] Erkki Ruoslahti,et al. Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression , 1998, The Journal of cell biology.
[44] F. Cosset,et al. In vivo selection of protease cleavage sites from retrovirus display libraries , 1998, Nature Biotechnology.
[45] R. Yauch,et al. Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. , 1998, Molecular biology of the cell.
[46] D. Grignon,et al. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth. , 1998, Cancer research.
[47] R. Hynes,et al. Novel Roles for α3β1 Integrin as a Regulator of Cytoskeletal Assembly and as a Trans-dominant Inhibitor of Integrin Receptor Function in Mouse Keratinocytes , 1998, The Journal of cell biology.
[48] W. Yu,et al. Requirement for Specific Proteases in Cancer Cell Intravasation as Revealed by a Novel Semiquantitative PCR-Based Assay , 1998, Cell.
[49] E. Nishida,et al. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest. , 1998, Science.
[50] A. Schauer,et al. Differential expression of growth arrest, DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas. , 1997, Anticancer research.
[51] E. Lengyel,et al. Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade , 1997, Oncogene.
[52] L. Zon,et al. Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK* , 1997, The Journal of Biological Chemistry.
[53] L. Ossowski,et al. Reduction in Surface Urokinase Receptor Forces Malignant Cells into a Protracted State of Dormancy , 1997, The Journal of cell biology.
[54] J. Folkman,et al. Angiostatin induces and sustains dormancy of human primary tumors in mice , 1996, Nature Medicine.
[55] E. Lengyel,et al. Regulation of urokinase‐type plasminogen activator expression by an ERK1‐dependent signaling pathway in a squamous cell carcinoma cell line , 1996, Journal of cellular biochemistry.
[56] Xiaozhong Wang,et al. Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase , 1996, Science.
[57] E. Lengyel,et al. Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras(*) , 1995, The Journal of Biological Chemistry.
[58] C. Marshall,et al. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells , 1994, Cell.
[59] A. Ashkenazi,et al. Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. , 1993, The Journal of biological chemistry.
[60] Robert Clarke,et al. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines , 1992, Journal of cellular physiology.
[61] J. Trent,et al. Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor. , 1991, Cancer research.
[62] L. Ossowski,et al. Changes in malignant phenotype of a human carcinoma conditioned by growth environment , 1983, Cell.
[63] S. Tokuoka,et al. Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74. , 1979, Journal of the National Cancer Institute.