Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance
暂无分享,去创建一个
[1] Roger L. Black,et al. Goodman and Gilman's The Pharmacological Basis of Therapeutics , 1991 .
[2] Kiyomi Ito,et al. Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches , 2004, Pharmaceutical Research.
[3] A. Li,et al. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. , 1999, Chemico-biological interactions.
[4] W. Stigelman,et al. Goodman and Gilman's the Pharmacological Basis of Therapeutics , 1986 .
[5] J. Houston,et al. PREDICTION OF METABOLIC CLEARANCE USING CRYOPRESERVED HUMAN HEPATOCYTES: KINETIC CHARACTERISTICS FOR FIVE BENZODIAZEPINES , 2005, Drug Metabolism and Disposition.
[6] Kiyomi Ito,et al. Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance , 2006, Pharmaceutical Research.
[7] R. Obach,et al. Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[8] A. Li,et al. Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[9] B. Burchell,et al. In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance. , 2002, The Journal of pharmacology and experimental therapeutics.
[10] K. Pang,et al. Retention of transporter activities in cryopreserved, isolated rat hepatocytes. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[11] J. Houston,et al. Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. , 1999, British journal of clinical pharmacology.
[12] J Brian Houston,et al. BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT , 2006, Drug Metabolism and Disposition.
[13] J Brian Houston,et al. Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance. , 2004, Drug metabolism and disposition: the biological fate of chemicals.
[14] J B Houston,et al. Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans , 2005, Xenobiotica; the fate of foreign compounds in biological systems.
[15] R. Austin,et al. A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES , 2005, Drug Metabolism and Disposition.
[16] Robert J Riley,et al. EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE , 2004, Drug Metabolism and Disposition.
[17] AC Moffat,et al. Clarke's analysis of drugs and poisons , 2003 .
[18] Masato Chiba,et al. Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[19] Yau Yi Lau,et al. Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[20] N. Hewitt,et al. Cryopreserved rat, dog and monkey hepatocytes: measurement of drug metabolizing enzymes in suspensions and cultures , 2004, Human & experimental toxicology.
[21] R. Obach,et al. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[22] J. Houston,et al. Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat. , 1999, The Journal of pharmacology and experimental therapeutics.
[23] Y. Sugiyama,et al. Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism. , 2002, Drug metabolism and pharmacokinetics.
[24] Robert J Riley,et al. THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES , 2005, Drug Metabolism and Disposition.
[25] Yuichi Sugiyama,et al. Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[26] Koujirou Yamamoto,et al. Prediction of total propofol clearance based on enzyme activities in microsomes from human kidney and liver , 2006, European Journal of Clinical Pharmacology.
[27] T. Baillie,et al. Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide , 2002, Journal of Pharmacology and Experimental Therapeutics.
[28] Aleksandra Galetin,et al. Prediction of In Vivo Drug-Drug Interactions from In Vitro Data , 2006, Clinical pharmacokinetics.