Modulating DNA-templated silver nanoclusters for fluorescence turn-on detection of thiol compounds.

Based on the fact that the fluorescence response pattern of a silver nanocluster to a specific analyte is highly dependent on the nature of the DNA template, we develop a novel fluorescence turn-on assay for thiol compounds with high specificity and sensitivity by modulating DNA-templated silver nanoclusters.

[1]  E. Wang,et al.  Oligonucleotide-stabilized fluorescent silver nanoclusters for sensitive detection of biothiols in biological fluids. , 2011, Biosensors & bioelectronics.

[2]  R. Jin,et al.  On the ligand's role in the fluorescence of gold nanoclusters. , 2010, Nano letters.

[3]  E. Gwinn,et al.  Sequence‐Dependent Fluorescence of DNA‐Hosted Silver Nanoclusters , 2008 .

[4]  A. Ajayaghosh,et al.  A near-infrared squaraine dye as a latent ratiometric fluorophore for the detection of aminothiol content in blood plasma. , 2008, Angewandte Chemie.

[5]  V. K. Kaushik,et al.  XPS core level spectra and Auger parameters for some silver compounds , 1991 .

[6]  Shaojun Dong,et al.  Sensitive detection of cysteine based on fluorescent silver clusters. , 2009, Biosensors & bioelectronics.

[7]  M. Sastry,et al.  Probing differential Ag+-nucleobase interactions with isothermal titration calorimetry (ITC): Towards patterned DNA metallization. , 2009, Nanoscale.

[8]  R. Martínez‐Máñez,et al.  Squaraines as fluoro-chromogenic probes for thiol-containing compounds and their application to the detection of biorelevant thiols. , 2004, Journal of the American Chemical Society.

[9]  Tom Vosch,et al.  Oligonucleotide-stabilized Ag nanocluster fluorophores. , 2008, Journal of the American Chemical Society.

[10]  Zusing Yang,et al.  Synthesis of highly fluorescent gold nanoparticles for sensing mercury(II). , 2007, Angewandte Chemie.

[11]  X. Qu,et al.  DNA/ligand/ion-based ensemble for fluorescence turn on detection of cysteine and histidine with tunable dynamic range. , 2010, Analytical chemistry.

[12]  M. Pileni,et al.  Synthesis of Highly Monodisperse Silver Nanoparticles from AOT Reverse Micelles: A Way to 2D and 3D Self-Organization , 1997 .

[13]  Shaojun Dong,et al.  Silver nanocluster-based fluorescent sensors for sensitive detection of Cu(II) , 2008 .

[14]  B. Tang,et al.  A rhodamine-based fluorescent probe containing a Se-N bond for detecting thiols and its application in living cells. , 2007, Journal of the American Chemical Society.

[15]  R. Glynn,et al.  Blood levels of homocysteine and increased risks of cardiovascular disease: causal or casual? , 2000, Archives of internal medicine.

[16]  Chih-Ching Huang,et al.  Silver nanoclusters as fluorescent probes for selective and sensitive detection of copper ions. , 2010, Chemical communications.

[17]  J B Schulz,et al.  Glutathione, oxidative stress and neurodegeneration. , 2000, European journal of biochemistry.

[18]  N. Alexander Spectrophotometric Assay for Sulfhydryl Groups Using N-Ethylmaleimide , 1958 .

[19]  Jason J. Han,et al.  A DNA--silver nanocluster probe that fluoresces upon hybridization. , 2010, Nano letters.