Fluorescent MoS2 Quantum Dots: Ultrasonic Preparation, Up-Conversion and Down-Conversion Bioimaging, and Photodynamic Therapy.

Small size molybdenum disulfide (MoS2) quantum dots (QDs) with desired optical properties were controllably synthesized by using tetrabutylammonium-assisted ultrasonication of multilayered MoS2 powder via OH-mediated chain-like Mo-S bond cleavage mode. The tunable up-bottom approach of precise fabrication of MoS2 QDs finally enables detailed experimental investigations of their optical properties. The synthesized MoS2 QDs present good down-conversion photoluminescence behaviors and exhibit remarkable up-conversion photoluminescence for bioimaging. The mechanism of the emerging photoluminescence was investigated. Furthermore, superior (1)O2 production ability of MoS2 QDs to commercial photosensitizer PpIX was demonstrated, which has great potential application for photodynamic therapy. These early affording results of tunable synthesis of MoS2 QDs with desired photo properties can lead to application in fields of biomedical and optoelectronics.

[1]  Yu Cao,et al.  Tunable Fabrication of Molybdenum Disulfide Quantum Dots for Intracellular MicroRNA Detection and Multiphoton Bioimaging. , 2015, Small.

[2]  Peiyi Wu,et al.  One‐Pot, Facile, and Versatile Synthesis of Monolayer MoS2/WS2 Quantum Dots as Bioimaging Probes and Efficient Electrocatalysts for Hydrogen Evolution Reaction , 2015 .

[3]  Zijian Guo,et al.  H2O2-activatable and O2-evolving nanoparticles for highly efficient and selective photodynamic therapy against hypoxic tumor cells. , 2015, Journal of the American Chemical Society.

[4]  Hongyan Shi,et al.  Water‐Soluble Monolayer Molybdenum Disulfide Quantum Dots with Upconversion Fluorescence , 2015 .

[5]  Jaebeom Lee,et al.  Plasmon-induced photoluminescence immunoassay for tuberculosis monitoring using gold-nanoparticle-decorated graphene. , 2014, ACS applied materials & interfaces.

[6]  Chun‐Sing Lee,et al.  A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation , 2014, Nature Communications.

[7]  Dapeng Liu,et al.  Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy. , 2013, Biomaterials.

[8]  X. Lou,et al.  Defect‐Rich MoS2 Ultrathin Nanosheets with Additional Active Edge Sites for Enhanced Electrocatalytic Hydrogen Evolution , 2013, Advanced materials.

[9]  Yu Zhang,et al.  Epitaxial monolayer MoS2 on mica with novel photoluminescence. , 2013, Nano letters.

[10]  Ching-Ping Wong,et al.  High‐Concentration Aqueous Dispersions of MoS2 , 2013 .

[11]  Hua Zhang,et al.  Metal Dichalcogenide Nanosheets: Preparation, Properties and Applications , 2013 .

[12]  Chunhai Fan,et al.  Single-layer MoS2-based nanoprobes for homogeneous detection of biomolecules. , 2013, Journal of the American Chemical Society.

[13]  J. Henych,et al.  Strongly luminescent monolayered MoS2 prepared by effective ultrasound exfoliation. , 2013, Nanoscale.

[14]  Bai Yang,et al.  Surface Chemistry Routes to Modulate the Photoluminescence of Graphene Quantum Dots: From Fluorescence Mechanism to Up‐Conversion Bioimaging Applications , 2012 .

[15]  P. Avouris,et al.  Electroluminescence in single layer MoS2. , 2012, Nano letters.

[16]  Qing Hua Wang,et al.  Electronics and optoelectronics of two-dimensional transition metal dichalcogenides. , 2012, Nature nanotechnology.

[17]  Jakob Kibsgaard,et al.  Engineering the surface structure of MoS2 to preferentially expose active edge sites for electrocatalysis. , 2012, Nature materials.

[18]  Zhiyuan Zeng,et al.  An effective method for the fabrication of few-layer-thick inorganic nanosheets. , 2012, Angewandte Chemie.

[19]  Cheolsoo Sone,et al.  Anomalous behaviors of visible luminescence from graphene quantum dots: interplay between size and shape. , 2012, ACS nano.

[20]  N. Oleinick,et al.  Optimization of a nanomedicine-based silicon phthalocyanine 4 photodynamic therapy (Pc 4-PDT) strategy for targeted treatment of EGFR-overexpressing cancers. , 2012, Molecular pharmaceutics.

[21]  S. Min,et al.  MoS₂ nanosheet phototransistors with thickness-modulated optical energy gap. , 2012, Nano letters.

[22]  Mustafa Lotya,et al.  Solvent Exfoliation of Transition Metal Dichalcogenides: Dispersability of Exfoliated Nanosheets Varies Only Weakly between Compounds /v Sol (mol/ml) Characterisation of Dispersions , 2022 .

[23]  Bai Yang,et al.  Graphene quantum dots with controllable surface oxidation, tunable fluorescence and up-conversion emission , 2012 .

[24]  Yu‐Chuan Lin,et al.  Growth of large-area and highly crystalline MoS2 thin layers on insulating substrates. , 2012, Nano letters.

[25]  Chunzhong Li,et al.  Demonstration of photoluminescence and metal-enhanced fluorescence of exfoliated MoS2. , 2012, Chemphyschem : a European journal of chemical physics and physical chemistry.

[26]  Mingwang Shao,et al.  Upconversion and downconversion fluorescent graphene quantum dots: ultrasonic preparation and photocatalysis. , 2012, ACS nano.

[27]  Kourosh Kalantar-Zadeh,et al.  Atomically thin layers of MoS2 via a two step thermal evaporation-exfoliation method. , 2012, Nanoscale.

[28]  Zhiyuan Zeng,et al.  Single-layer semiconducting nanosheets: high-yield preparation and device fabrication. , 2011, Angewandte Chemie.

[29]  Youngki Yoon,et al.  How good can monolayer MoS₂ transistors be? , 2011, Nano letters.

[30]  A. Radenović,et al.  Single-layer MoS2 transistors. , 2011, Nature nanotechnology.

[31]  J. Coleman,et al.  Two-Dimensional Nanosheets Produced by Liquid Exfoliation of Layered Materials , 2011, Science.

[32]  K. Novoselov,et al.  Hunting for monolayer boron nitride: optical and Raman signatures. , 2010, Small.

[33]  Younan Xia,et al.  Aqueous-phase synthesis of single-crystal ceria nanosheets. , 2010, Angewandte Chemie.

[34]  J. Shan,et al.  Atomically thin MoS₂: a new direct-gap semiconductor. , 2010, Physical review letters.

[35]  A. Splendiani,et al.  Emerging photoluminescence in monolayer MoS2. , 2010, Nano letters.

[36]  Mingyuan Ge,et al.  Large-scale synthesis of SnO2 nanosheets with high lithium storage capacity. , 2010, Journal of the American Chemical Society.

[37]  Fabian Duerr,et al.  Fractional quantum Hall effect and insulating phase of Dirac electrons in graphene , 2009, Nature.

[38]  M. Osada,et al.  Exfoliated oxide nanosheets: new solution to nanoelectronics , 2009 .

[39]  R. Nitschke,et al.  Quantum dots versus organic dyes as fluorescent labels , 2008, Nature Methods.

[40]  G. Fudenberg,et al.  Ultrahigh electron mobility in suspended graphene , 2008, 0802.2389.

[41]  Michael S. Fuhrer,et al.  Realization and electrical characterization of ultrathin crystals of layered transition-metal dichalcogenides , 2007 .

[42]  P. Kim,et al.  Experimental observation of the quantum Hall effect and Berry's phase in graphene , 2005, Nature.

[43]  A. Geim,et al.  Two-dimensional gas of massless Dirac fermions in graphene , 2005, Nature.

[44]  J. Wilcoxon,et al.  Catalytic Properties of Single Layers of Transition Metal Sulfide Catalytic Materials , 2005 .

[45]  K. Novoselov,et al.  Two-dimensional atomic crystals. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[46]  H. Freund,et al.  Cluster core-level binding-energy shifts: the role of lattice strain. , 2004, Physical review letters.

[47]  D. F. Kelley,et al.  Size-Dependent Spectroscopy of MoS2 Nanoclusters , 2002 .

[48]  F. Matthias Bickelhaupt,et al.  Chemistry with ADF , 2001, J. Comput. Chem..

[49]  P. Newcomer,et al.  Synthesis and optical properties of MoS2 and isomorphous nanoclusters in the quantum confinement regime , 1997 .

[50]  W. Jaegermann,et al.  Li intercalation across and along the van der Waals surfaces of MoS2(0001) , 1995 .