A global analysis of cross-talk in a mammalian cellular signalling network

[1]  K. Ozato,et al.  IRF-8/Interferon (IFN) Consensus Sequence-binding Protein Is Involved in Toll-like Receptor (TLR) Signaling and Contributes to the Cross-talk between TLR and IFN-γ Signaling Pathways* , 2006, Journal of Biological Chemistry.

[2]  C. Akdis,et al.  Mechanisms of immune suppression by interleukin‐10 and transforming growth factor‐β: the role of T regulatory cells , 2006, Immunology.

[3]  J. Lord,et al.  Chemokine‐ and adhesion‐dependent survival of neutrophils after transmigration through cytokine‐stimulated endothelium , 2006, Journal of leukocyte biology.

[4]  Richard A Flavell,et al.  Transforming growth factor-beta regulation of immune responses. , 2006, Annual review of immunology.

[5]  M. Caligiuri,et al.  STAT‐1‐mediated repression of monocyte interleukin‐10 gene expression in vivo , 2006, European journal of immunology.

[6]  G. Burnstock Pathophysiology and Therapeutic Potential of Purinergic Signaling , 2006, Pharmacological Reviews.

[7]  H. Yu,et al.  GLUTAMINE INHIBITS LIPOPOLYSACCHARIDE-INDUCED CYTOPLASMIC PHOSPHOLIPASE A2 ACTIVATION AND PROTECTS AGAINST ENDOTOXIN SHOCK IN MOUSE , 2006, Shock.

[8]  C. Brosnan,et al.  Exacerbation of Experimental Autoimmune Encephalomyelitis in P2X7R−/− Mice: Evidence for Loss of Apoptotic Activity in Lymphocytes1 , 2006, The Journal of Immunology.

[9]  M. Parmentier,et al.  Extracellular adenine nucleotides inhibit the release of major monocyte recruiters by human monocyte‐derived dendritic cells , 2006, FEBS letters.

[10]  J. Thurman,et al.  The Central Role of the Alternative Complement Pathway in Human Disease1 , 2006, The Journal of Immunology.

[11]  E. Stanley,et al.  Colony-stimulating factor-1 in immunity and inflammation. , 2006, Current opinion in immunology.

[12]  L. O’Neill,et al.  How Toll-like receptors signal: what we know and what we don't know. , 2006, Current opinion in immunology.

[13]  K. Isse,et al.  Interferon γ accelerates NF-κB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction , 2006, Journal of Clinical Pathology.

[14]  G. Mouchiroud,et al.  The interferon‐inducible gene, Ifi204, is transcriptionally activated in response to M‐CSF, and its expression favors macrophage differentiation in myeloid progenitor cells , 2006, Journal of leukocyte biology.

[15]  Paul B. Mann,et al.  The Complex Mechanism of Antibody-Mediated Clearance of Bordetella from the Lungs Requires TLR41 , 2005, The Journal of Immunology.

[16]  Rajagopal N. Aravalli,et al.  Cutting Edge: TLR2-Mediated Proinflammatory Cytokine and Chemokine Production by Microglial Cells in Response to Herpes Simplex Virus1 , 2005, The Journal of Immunology.

[17]  K. Heeg,et al.  “Host Tissue Damage” Signal ATP Promotes Non-directional Migration and Negatively Regulates Toll-like Receptor Signaling in Human Monocytes* , 2005, Journal of Biological Chemistry.

[18]  S. Jin,et al.  Specific Role of Phosphodiesterase 4B in Lipopolysaccharide-Induced Signaling in Mouse Macrophages 1 , 2005, The Journal of Immunology.

[19]  A. Dunne,et al.  Adaptor usage and Toll‐like receptor signaling specificity , 2005, FEBS letters.

[20]  T. Graeber,et al.  TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells , 2005, Nature Medicine.

[21]  F. Liew,et al.  Negative regulation of Toll-like receptor-mediated immune responses , 2005, Nature Reviews Immunology.

[22]  I. Haga,et al.  The role of Toll-like receptors in the host response to viruses. , 2005, Molecular immunology.

[23]  J. McHowat,et al.  Phospholipase A2 inhibitors as potential anti-inflammatory agents. , 2005, Current pharmaceutical design.

[24]  S. Hammer,et al.  Overlapping Signaling Pathways of Sphingosine 1-Phosphate and TGF-β in the Murine Langerhans Cell Line XS521 , 2005, The Journal of Immunology.

[25]  Joe G. N. Garcia,et al.  In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. , 2005, Cellular signalling.

[26]  K. Heeg,et al.  Suppressor of Cytokine Signaling (SOCS) Proteins Indirectly Regulate Toll-like Receptor Signaling in Innate Immune Cells*♦ , 2004, Journal of Biological Chemistry.

[27]  Chunli Feng,et al.  Adenine Nucleotides Inhibit Cytokine Generation by Human Mast Cells through a Gs-Coupled Receptor1 , 2004, The Journal of Immunology.

[28]  J. Hamilton,et al.  Mini ReviewGM-CSF Biology , 2004, Growth factors.

[29]  C. D. Krause,et al.  Interferons, interferon‐like cytokines, and their receptors , 2004, Immunological reviews.

[30]  A. Roberts,et al.  Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis. , 2004, The Journal of investigative dermatology.

[31]  J. Boeynaems,et al.  Involvement of multiple P2Y receptors and signaling pathways in the action of adenine nucleotides diphosphates on human monocyte‐derived dendritic cells , 2004, Journal of leukocyte biology.

[32]  A. Roberts,et al.  Involvement of Smad Signaling in Sphingosine 1-Phosphate-mediated Biological Responses of Keratinocytes* , 2004, Journal of Biological Chemistry.

[33]  A. Ohta,et al.  Cutting Edge: Physiologic Attenuation of Proinflammatory Transcription by the Gs Protein-Coupled A2A Adenosine Receptor In Vivo , 2004, The Journal of Immunology.

[34]  Y. Kuroda,et al.  Prostaglandin E2 receptors EP2 and EP4 are up‐regulated in peritoneal macrophages and joints of pristane‐treated mice and modulate TNF‐α and IL‐6 production , 2004, Journal of leukocyte biology.

[35]  Takao Shimizu,et al.  Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. , 2004, The Journal of clinical investigation.

[36]  Osamu Takeuchi,et al.  The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection , 2004, The Journal of experimental medicine.

[37]  J. Chun,et al.  Lysophospholipid receptors: signaling and biology. , 2004, Annual review of biochemistry.

[38]  H. Rabb,et al.  Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. , 2004, American journal of respiratory and critical care medicine.

[39]  N. Gray,et al.  Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate* , 2004, Journal of Biological Chemistry.

[40]  H. Tilg,et al.  Type I interferons and their therapeutic role in Th2-regulated inflammatory disorders , 2004, Expert opinion on biological therapy.

[41]  M. Daha,et al.  Mini‐review: A pivotal role for innate immunity in the clearance of apoptotic cells , 2004, European journal of immunology.

[42]  J. Hamilton,et al.  Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[43]  M. Teixeira,et al.  Sponge‐induced angiogenesis and inflammation in PAF receptor‐deficient mice (PAFR‐KO) , 2004, British journal of pharmacology.

[44]  C. D. Krause,et al.  Interleukin-10 and related cytokines and receptors. , 2004, Annual review of immunology.

[45]  M. Netea,et al.  Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells , 2004, The Journal of Immunology.

[46]  F. Tremblay,et al.  Sphingosine 1‐phosphate effect on endothelial cell PAF synthesis: Role in cellular migration , 2003, Journal of cellular biochemistry.

[47]  M. Caligiuri,et al.  The role of STAT1 in viral sensitization to LPS , 2003, Journal of endotoxin research.

[48]  Paul J Hertzog,et al.  The interferon in TLR signaling: more than just antiviral. , 2003, Trends in immunology.

[49]  A. Lacy-Hulbert,et al.  Apoptotic Cells and Innate Immune Stimuli Combine to Regulate Macrophage Cytokine Secretion 1 , 2003, The Journal of Immunology.

[50]  T. Hartung,et al.  Cyclic AMP increases endogenous granulocyte colony‐stimulating factor formation in monocytes and THP‐1 macrophages despite attenuated TNF‐α formation , 2003, European journal of immunology.

[51]  Takao Shimizu,et al.  Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. , 2003, Microbes and infection.

[52]  S. Akira,et al.  Role of adapters in Toll-like receptor signalling. , 2003, Biochemical Society transactions.

[53]  K. Heeg,et al.  TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity. , 2003, Vaccine.

[54]  G. Hatch,et al.  Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFα, LPS and M-CSF in human monocytes and macrophages , 2003, Molecular and Cellular Biochemistry.

[55]  N. Brot,et al.  Opsonization of Apoptotic Cells and Its Effect on Macrophage and T Cell Immune Responses , 2003, Annals of the New York Academy of Sciences.

[56]  Rolf Rossaint,et al.  Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3 1 , 2003, The Journal of Immunology.

[57]  K. Heeg,et al.  Synergistic and antagonistic interactions between LPS and superantigens , 2003, Journal of endotoxin research.

[58]  S. Akira,et al.  Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling1 , 2002, The Journal of Immunology.

[59]  Temple F. Smith,et al.  Overview of the Alliance for Cellular Signaling , 2002, Nature.

[60]  H. Kettenmann,et al.  Interferon‐γ differentially modulates the release of cytokines and chemokines in lipopolysaccharide‐ and pneumococcal cell wall‐stimulated mouse microglia and macrophages , 2002 .

[61]  R. Flavell,et al.  The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors , 2002, Nature.

[62]  M. Fenton,et al.  Toll-Like Receptor 4 and Toll-IL-1 Receptor Domain-Containing Adapter Protein (TIRAP)/Myeloid Differentiation Protein 88 Adapter-Like (Mal) Contribute to Maximal IL-6 Expression in Macrophages1 , 2002, The Journal of Immunology.

[63]  A. Descoteaux,et al.  Modulation of lipopolysaccharide‐induced NF‐IL6 activation by protein kinase C‐α in a mouse macrophage cell line , 2002, European journal of immunology.

[64]  M. Bergmann,et al.  Immunomodulatory effects of vasoactive catecholamines. , 2002, Wiener klinische Wochenschrift.

[65]  P. Newburger,et al.  Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. , 2002, Blood.

[66]  M. Takami,et al.  Stimulation by Toll-Like Receptors Inhibits Osteoclast Differentiation1 , 2002, The Journal of Immunology.

[67]  A. Nicolini,et al.  MODULATION OF PGE2 AND TNFα BY NITRIC OXIDE IN RESTING AND LPS-ACTIVATED RAW 264.7 CELLS , 2002 .

[68]  S. Taffet,et al.  The proximal promoter region is essential for lipopolysaccharide induction and cyclic AMP inhibition of mouse tumor necrosis factor-alpha. , 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[69]  G. Zimmerman,et al.  The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis , 2002, Critical care medicine.

[70]  J. J. Moreno,et al.  Role of Ca(2+)-independent phospholipase A(2) and cyclooxygenase/lipoxygenase pathways in the nitric oxide production by murine macrophages stimulated by lipopolysaccharides. , 2002, Nitric oxide : biology and chemistry.

[71]  A. Kolada,et al.  Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2. , 2002, Cellular signalling.

[72]  Shizuo Akira,et al.  Toll-like receptors as adjuvant receptors. , 2002, Biochimica et biophysica acta.

[73]  S. Ullrich,et al.  Platelet-activating Factor, a Molecular Sensor for Cellular Damage, Activates Systemic Immune Suppression , 2002, The Journal of experimental medicine.

[74]  V. Sanders,et al.  Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. , 2001, Pharmacological reviews.

[75]  J. Berzofsky,et al.  Mechanisms of cytokine synergy essential for vaccine protection against viral challenge. , 2001, International immunology.

[76]  T. Ohmori,et al.  Sphingosine 1-phosphate: synthesis and release. , 2001, Prostaglandins & other lipid mediators.

[77]  Allan Randrup Thomsen,et al.  Viral Infection Causes Rapid Sensitization to Lipopolysaccharide: Central Role of IFN-αβ1 , 2001, The Journal of Immunology.

[78]  S. Akira,et al.  Toll-like receptors and their signaling mechanism in innate immunity , 2001, Acta odontologica Scandinavica.

[79]  S. Akira,et al.  Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways1 , 2000, The Journal of Immunology.

[80]  J. Pugin,et al.  β-Adrenergic agonists exert their “anti-inflammatory” effects in monocytic cells through the IκB/NF-κB pathway , 2000 .

[81]  Judith R. Campbell,et al.  Cytokines Enhance Opsonophagocytosis of Type III Group B Streptococcus , 2000, Journal of Perinatology.

[82]  S. Vogel,et al.  Inhibition of Lipopolysaccharide-Induced Signal Transduction in Endotoxin-Tolerized Mouse Macrophages: Dysregulation of Cytokine, Chemokine, and Toll-Like Receptor 2 and 4 Gene Expression1 , 2000, The Journal of Immunology.

[83]  A S Slutsky,et al.  Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants. , 1999, American journal of respiratory and critical care medicine.

[84]  A. Sala,et al.  Cyclooxygenase-2-dependent generation of 8-epiprostaglandin F2α by lipopolysaccharide-activated J774 macrophages , 1999, Inflammation Research.

[85]  M. McCloskey,et al.  Chemotaxis of rat mast cells toward adenine nucleotides. , 1999, Journal of immunology.

[86]  Jianjun Gao,et al.  Autocrine/Paracrine IFN-αβ Mediates the Lipopolysaccharide-Induced Activation of Transcription Factor Stat1α in Mouse Macrophages: Pivotal Role of Stat1α in Induction of the Inducible Nitric Oxide Synthase Gene , 1998, The Journal of Immunology.

[87]  C. Caldarera,et al.  ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis. , 1997, Biochemical Journal.

[88]  L. Rohrschneider,et al.  Growth and differentiation signals regulated by the M‐CSF receptor , 1997, Molecular reproduction and development.

[89]  L. Hang,et al.  Immunoregulatory cytokines modify Escherichia coli induced uroepithelial cell IL-6 and IL-8 responses. , 1996, Cytokine.

[90]  S. Leibler,et al.  Kinetics of self-assembling microtubules: an "inverse problem" in biochemistry. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[91]  J. Ihle Cytokine receptor signalling , 1995, Nature.

[92]  S. Lightman,et al.  Nucleotides as Extracellular Signalling Molecules , 1995, Journal of neuroendocrinology.

[93]  J. Gamble,et al.  The role of granulocyte-macrophage and granulocyte colony-stimulating factors in neutrophil transendothelial migration: comparison with interleukin-8. , 1994, Experimental hematology.

[94]  J. Mcghee,et al.  Transforming growth factor-beta and IL-1 beta act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6. , 1993, Journal of immunology.

[95]  D. Riches,et al.  Expression of interferon-beta during the triggering phase of macrophage cytocidal activation. Evidence for an autocrine/paracrine role in the regulation of this state. , 1991, The Journal of biological chemistry.

[96]  S. Jacobsen,et al.  Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[97]  M. Feldmann,et al.  Interleukin 4 induces interleukin 6 production by endothelial cells: Synergy with interferon‐γ , 1991, European journal of immunology.

[98]  A. Goldbeter,et al.  Latency correlates with period in a model for signal-induced Ca2+ oscillations based on Ca2(+)-induced Ca2+ release. , 1990, Cell regulation.

[99]  A Goldbeter,et al.  Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[100]  J. Vilček,et al.  IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. , 1989, Journal of immunology.

[101]  C. Baglioni,et al.  Bacterial lipopolysaccharide and gamma interferon induce transcription of beta interferon mRNA and interferon secretion in murine macrophages , 1989, Journal of virology.

[102]  K. Isse,et al.  Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction. , 2006, Journal of clinical pathology.

[103]  B. Lakatoš,et al.  ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria. , 2006, Biochimica et biophysica acta.

[104]  J. Köhl,et al.  Complement and Toll-like receptors: key regulators of adaptive immune responses. , 2006, Molecular immunology.

[105]  R. Flavell,et al.  TGFbeta-mediated immunoregulation. , 2006, Ernst Schering Research Foundation workshop.

[106]  C. Akdis,et al.  T regulatory cells in allergy. , 2006, Chemical immunology and allergy.

[107]  Ching-Mei Hsu,et al.  Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. , 2005, Journal of biomedical science.

[108]  T. Kishimoto Interleukin-6: from basic science to medicine--40 years in immunology. , 2005, Annual review of immunology.

[109]  A. Nicolini,et al.  Modulation of PGE(2) and TNFalpha by nitric oxide and LPS-activated RAW 264.7 cells. , 2002, Cytokine.

[110]  G. Sen,et al.  Viruses and interferons. , 2001, Annual review of microbiology.

[111]  R. Coffman,et al.  Interleukin-10 and the interleukin-10 receptor. , 2001, Annual review of immunology.

[112]  S Rozen,et al.  Primer3 on the WWW for general users and for biologist programmers. , 2000, Methods in molecular biology.

[113]  S. Akira,et al.  Critical roles of Toll-like receptors in host defense. , 2000, Critical reviews in immunology.

[114]  S. Vogel,et al.  Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. , 1998, Journal of immunology.

[115]  B. Cronstein Adenosine, an endogenous anti-inflammatory agent. , 1994, Journal of applied physiology.

[116]  R. Gilkey An evaluation of the , 1982 .

[117]  R. Mojena,et al.  Hierarchical Grouping Methods and Stopping Rules: An Evaluation , 1977, Comput. J..

[118]  Mechanistic insights , 2022 .