Accelerated Forgetting in Association with Temporal Lobe Epilepsy and Paraneoplastic Encephalitis

The association between epilepsy and amnesia is studied in patient J.T. who presented with a very unusual pattern of memory loss with retention of information for hours to days but rapid forgetting of information that exceeded this time frame. J.T.'s unusual memory profile was studied with several tests administered over week-long intervals of time. There was evidence that his retention decreased in conjunction with increased seizures. During a trial of paraldehyde, a decrease in seizure frequency was associated with enhanced memory. J.T.'s memory problem was unlike that described in prototypical cases of amnesia. His day-long retention of new information alongside his absolute loss of that information days later is consistent with the idea that consolidation is a process that occurs over lengthy periods of time.

[1]  Michael D. Kopelman,et al.  Handbook of memory disorders , 1995 .

[2]  P Alvarez,et al.  Memory consolidation and the medial temporal lobe: a simple network model. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Mesulam,et al.  Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia , 1994, Neurology.

[4]  J. D. McGaugh,et al.  Interaction of GABAergic and beta-noradrenergic drugs in the regulation of memory storage. , 1994, Behavioral and neural biology.

[5]  L R Squire,et al.  Memory and forgetting: long-term and gradual changes in memory storage. , 1994, International review of neurobiology.

[6]  N. Kapur.  Transient epileptic amnesia--a clinical update and a reformulation. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[7]  T L Babb,et al.  Hippocampal neuron loss and memory scores before and after temporal lobe surgery for epilepsy. , 1993, Archives of neurology.

[8]  N. Kapur.  Focal Retrograde Amnesia in Neurological Disease: A Critical Review , 1993, Cortex.

[9]  Alan J. Parkin,et al.  Neuropsychology of the Amnesic Syndrome , 1993 .

[10]  E. Lugaresi,et al.  Epileptic Amnesic Syndrome , 1992, Epilepsia.

[11]  N Butters,et al.  The dissociation of anterograde and retrograde amnesia in a patient with herpes encephalitis. , 1992, Journal of clinical and experimental neuropsychology.

[12]  N. Kapur,et al.  Focal Retrograde Amnesia: A Long Term Clinical and Neuropsychological Follow-Up , 1989, Cortex.

[13]  Arthur P. Shimamura,et al.  The neurology of memory: quantitative assessment of retrograde amnesia in two groups of amnesic patients , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  E. Lugaresi,et al.  Epilepsy Presenting as Memory Disturbances , 1988, Epilepsia.

[15]  J. Oxbury,et al.  Hippocampal neuron loss in temporal lobe epilepsy: Correlation with early childhood convulsions , 1987, Annals of neurology.

[16]  Frederick Andermann,et al.  Magnetic resonance imaging in temporal lobe epilepsy: Pathological correlations , 1987, Annals of neurology.

[17]  S. F. Williams,et al.  Physiological and behavioural consequences of seizures induced in the rat by intrahippocampal tetanus toxin. , 1987, Brain : a journal of neurology.

[18]  J. Mellanby.  A comparison of the effects of epilepsy and ageing on learning and hippocampal physiology , 1986, Acta neurologica Scandinavica. Supplementum.

[19]  O. Saitoh,et al.  Verbal Memory Disturbances in Left Temporal Lobe Epileptics , 1984, Cortex.

[20]  L. Cermak,et al.  The anterograde and retrograde retrieval ability of a patient with amnesia due to encephalitis , 1983, Neuropsychologia.

[21]  L. Squire,et al.  Electroconvulsive Therapy and Complaints of Memory Dysfunction: A Prospective Three-Year Follow-up Study , 1983, British Journal of Psychiatry.

[22]  Richard H. Mattson,et al.  Memory Function in Focal Epilepsy: A Comparison of Non-Surgical, Unilateral Temporal Lobe and Frontal Lobe Samples , 1980, Cortex.

[23]  C Umiltà,et al.  Hemisphere‐dependent Cognitive Performances in Epileptic Patients , 1979, Epilepsia.

[24]  N Butters,et al.  Temporal gradients in the retrograde amnesia of patients with alcoholic Korsakoff's disease. , 1979, Archives of neurology.

[25]  F. Huppert,et al.  Dissociation between learning and remembering in organic amnesia , 1978, Nature.

[26]  L. Squire.  A stable impairment in remote memory following electroconvulsive therapy , 1975, Neuropsychologia.

[27]  F. Lhermitte,et al.  [Neuropsychologic analysis and differentiation of amnesia syndromes]. , 1972, Revue neurologique.

[28]  D Marr,et al.  Simple memory: a theory for archicortex. , 1971, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[29]  B. Milner.  Amnesia following operation on the temporal lobes , 1996 .

[30]  W. Scoville,et al.  LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS , 1957, Journal of neurology, neurosurgery, and psychiatry.

[31]  D. A. Grant,et al.  A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. , 1948, Journal of experimental psychology.