论文信息 - Stereotactic laser therapy in cerebral gliomas.

Stereotactic laser therapy in cerebral gliomas.

The 1.06 micron Nd:YAG laser and a new fiberoptic delivery system, the Interstitial Thermo-Therapy (ITT) laser fibre, allows stereotactic interstitial irradiation of cerebral tumours. In experimental rat brain studies we found typical laser-tissue effects with a central necrosis and a sharply demarcated oedema towards the normal brain. The size of the lesion depended on the energy and exposure time applied. In a pilot series we treated 5 patients with cerebral gliomas WHO grade II-III in functionally important regions and monitored the therapeutic effects by MR imaging and PET scan. Early post-operative results showed irreversible necrotic changes in the tumour centre and reversible oedematous changes at the tumour margin. Long-term results will show if stereotactic interstitial laser therapy is a useful supplementary method in the treatment of malignant cerebral tumours.

[1] F A Jolesz,et al. MR imaging of laser-tissue interactions. , 1988, Radiology.

[2] D L Parker,et al. Temperature distribution measurements in two-dimensional NMR imaging. , 1983, Medical physics.

[3] M. Nauenberg,et al. Thermal effects of laser radiation in biological tissue. , 1983, Biophysical journal.

[4] Effects of Laser Sources (Argon, Nd:YAG, CO2) on the Elastic Resistance of the Vessel Wall: Histological and Physical Study , 1983, Lasers in surgery and medicine.

[5] A. Welch,et al. The thermal response of laser irradiated tissue , 1984, IEEE Journal of Quantum Electronics.

[6] T. Foster,et al. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. , 1984, Medical physics.