Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients

Infections with adenoviruses (ADVs) can result in considerable mortality and morbidity in solid organ transplant (SOT) recipients. Standard therapy for ADV infections in transplant recipients is not established. At our institution, intravenous cidofovir and immunoglobulin have been used to treat disseminated or invasive ADV in SOT and hematopoietic stem cell transplant recipients.

[1]  K. Arheart,et al.  Virologic response with 2 different cidofovir dosing regimens for preemptive treatment of adenovirus DNAemia in pediatric solid organ transplant recipients , 2018, Pediatric transplantation.

[2]  J. Kurtzberg,et al.  Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial. , 2017, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[3]  A. Miki,et al.  Clinical characteristics and outcomes of adenovirus infection of the urinary tract after renal transplantation , 2016, Transplant infectious disease : an official journal of the Transplantation Society.

[4]  U. Park,et al.  Successful treatment of disseminated adenovirus infection with ribavirin and intravenous immunoglobulin in an adult renal transplant recipient: a case report. , 2015, Transplantation proceedings.

[5]  J. Hoffman,et al.  Adenovirus in Solid Organ Transplantation , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[6]  J. Alberú,et al.  Fever, Haematuria, and Acute Graft Dysfunction in Renal Transplant Recipients Secondary to Adenovirus Infection: Two Case Reports , 2013, Case reports in nephrology.

[7]  W. Chantratita,et al.  Adenovirus Disease after Kidney Transplantation: Course of Infection and Outcome in Relation to Blood Viral Load and Immune Recovery , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[8]  A. Kalil,et al.  Adenovirus Infections in Pediatric Small Bowel Transplant Recipients , 2010, Transplantation.

[9]  A. Fenves,et al.  Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin , 2010, Transplant infectious disease : an official journal of the Transplantation Society.

[10]  M. Echavarria Adenoviruses in Immunocompromised Hosts , 2008, Clinical Microbiology Reviews.

[11]  Y. Toyoda,et al.  Successful cidofovir treatment in an adult heart transplant recipient with severe adenovirus pneumonia. , 2008, The Journal of Heart and Lung Transplantation.

[12]  X. Pang,et al.  Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance , 2006, The Journal of Heart and Lung Transplantation.

[13]  D. Hébert,et al.  Adenoviral Infections in Pediatric Transplant Recipients: A Hospital-Based Study , 2006, The Pediatric infectious disease journal.

[14]  Deepali Kumar,et al.  A Surveillance Study of Adenovirus Infection in Adult Solid Organ Transplant Recipients , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[15]  M. Schilham,et al.  Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[16]  C. Rouzioux,et al.  Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[17]  T. Fishbein,et al.  ADENOVIRUS INFECTION IN PEDIATRIC SMALL BOWEL TRANSPLANTATION RECIPIENTS , 2003, Transplantation.

[18]  N. Kapoor,et al.  Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. , 2001, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[19]  D. Neau,et al.  Intravenous cidofovir-induced iritis. , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  M. Torroella,et al.  Adenovirus enterocolitis in human small bowel transplants. , 1998, Pediatric transplantation.

[21]  D. Snydman,et al.  Adenovirus infection in adult orthotopic liver transplant recipients: incidence and clinical significance. , 1998, The Journal of infectious diseases.

[22]  N. Alp,et al.  Disseminated adenovirus infection after liver transplantation and its possible treatment with ganciclovir. , 1989, The Journal of infection.

[23]  A Hornsleth,et al.  [Clinical virology]. , 1977, Ugeskrift for laeger.