Independent validation of experimental results requires timely and unrestricted access to animal models and reagents

1 Program in Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, Michigan, United States of America, 2 Orthopedic Research Labs, Boston Children’s Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Musculoskeletal Integrity Program, Hospital for Special Surgery Research Institute, New York, New York, United States of America, 4 Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 5 Bioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, Michigan, United States of America, 6 Vivarium and Transgenics Core, Van Andel Institute, Grand Rapids, Michigan, United States of America

[1]  Lihua Zhou,et al.  Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology , 2016, Disease Models & Mechanisms.

[2]  F. Mseeh,et al.  Lrp5 functions in bone to regulate bone mass , 2011, Nature Medicine.

[3]  A. Robling,et al.  Reply to Lrp5 regulation of bone mass and gut serotonin synthesis , 2014, Nature Medicine.

[4]  G. Sumara,et al.  Endocrine Regulation of Male Fertility by the Skeleton , 2011, Cell.

[5]  T. Ishimoto,et al.  Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass , 2020, PLoS genetics.

[6]  Allan Bradley,et al.  Increased bone formation in osteocalcin-deficient mice , 1996, Nature.

[7]  J. John Mann,et al.  Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum , 2008, Cell.

[8]  N. Alenina,et al.  Measurement of Plasma, Serum, and Platelet Serotonin in Individuals With High Bone Mass and Mutations in LRP5 , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  Cassandra R Diegel,et al.  An osteocalcin-deficient mouse strain without endocrine abnormalities , 2019, bioRxiv.

[10]  Kevin Grove,et al.  Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. , 2019, Cell metabolism.

[11]  G. Karsenty,et al.  Lrp5 regulation of bone mass and serotonin synthesis in the gut , 2014, Nature Medicine.

[12]  J. Fowlkes,et al.  Postnatal loss of the insulin receptor in osteoprogenitor cells does not impart a metabolic phenotype , 2020, Scientific Reports.

[13]  M. McKee,et al.  Endocrine Regulation of Energy Metabolism by the Skeleton , 2007, Cell.