Optical probe for d-glucose based on cationic polymer quencher/receptor and anionic dye in aqueous solution

Abstract A novel fluorescence probe for d -glucose is formed by anionic dye NAHBDS and cationic boronic acid functionalized poly(benzyl viologen salts) q-BBV2+. The two-component probe showed reversible fluorescence “on–off” response for d -glucose. For probe, the specific bonding way of anionic dye and cationic polymer quencher/receptor provides an appropriate microenvironment and multidimensional bonding sites which actively catch d -glucose molecule.

[1]  Adam Heller,et al.  Electrochemical glucose sensors and their applications in diabetes management. , 2008, Chemical reviews.

[2]  X. Yao,et al.  Targeted quantitation of overexpressed and endogenous cystic fibrosis transmembrane conductance regulator using multiple reaction monitoring tandem mass spectrometry and oxygen stable isotope dilution. , 2010, Analytical chemistry.

[3]  S. Shinkai,et al.  Saccharide Sensing with Molecular Receptors Based on Boronic Acid , 1996 .

[4]  A. Schepartz,et al.  Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid. , 2009, Journal of the American Chemical Society.

[5]  D. Cordes,et al.  The interaction of boronic acid-substituted viologens with pyranine: the effects of quencher charge on fluorescence quenching and glucose response. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[6]  Xiaoju Wang,et al.  A highly sensitive water-soluble system to sense glucose in aqueous solution. , 2011, Organic & biomolecular chemistry.

[7]  B. M. Pinto,et al.  Structure proof and synthesis of kotalanol and de-O-sulfonated kotalanol, glycosidase inhibitors isolated from an herbal remedy for the treatment of type-2 diabetes. , 2009, Journal of the American Chemical Society.

[8]  Z. Guan,et al.  Saccharide-peptide hybrid copolymers as biomaterials. , 2005, Angewandte Chemie.

[9]  D. Cordes,et al.  Continuous glucose sensing with a fluorescent thin-film hydrogel. , 2003, Angewandte Chemie.

[10]  D. Cordes,et al.  Monosaccharide Detection with 4,7-Phenanthrolinium Salts: Charge-Induced Fluorescence Sensing , 2003 .

[11]  Raluca Dinu,et al.  Chromophore-Containing Polymers for Trace Explosive Sensors , 2008 .

[12]  Yundong Wu,et al.  Highly enantioselective recognition of structurally diverse alpha-hydroxycarboxylic acids using a fluorescent sensor. , 2010, Angewandte Chemie.

[13]  T. Swager,et al.  Conjugated polymer-based chemical sensors. , 2000, Chemical reviews.

[14]  W. Hancock,et al.  Characterization of the glycosylation occupancy and the active site in the follow-on protein therapeutic: TNK-tissue plasminogen activator. , 2010, Analytical chemistry.

[15]  Soya Gamsey,et al.  Boronic acid-based bipyridinium salts as tunable receptors for monosaccharides and alpha-hydroxycarboxylates. , 2007, Journal of the American Chemical Society.

[16]  Xiaoju Wang,et al.  Detection of glucose based on reversible “on–off” fluorescence systems in aqueous solution , 2011 .

[17]  Alexander Schiller,et al.  A fluorescent sensor array for saccharides based on boronic Acid appended bipyridinium salts. , 2007, Angewandte Chemie.

[18]  Elizabeth M. Nolan,et al.  Tools and tactics for the optical detection of mercuric ion. , 2008, Chemical reviews.

[19]  Joseph R Lakowicz,et al.  Saccharide Detection Based on the Amplified Fluorescence Quenching of a Water-Soluble Poly(phenylene ethynylene) by a Boronic Acid Functionalized Benzyl Viologen Derivative. , 2002, Langmuir : the ACS journal of surfaces and colloids.

[20]  Itamar Willner,et al.  Optical detection of glucose and acetylcholine esterase inhibitors by H2O2-sensitive CdSe/ZnS quantum dots. , 2008, Angewandte Chemie.

[21]  E. Anslyn.  Supramolecular analytical chemistry. , 2007, The Journal of organic chemistry.

[22]  M. Olmstead,et al.  The effect of boronic acid-positioning in an optical glucose-sensing ensemble , 2006 .

[23]  Soya Gamsey,et al.  Fluorescent quantum dots with boronic acid substituted viologens to sense glucose in aqueous solution. , 2006, Angewandte Chemie.

[24]  Michael Famulok,et al.  Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy. , 2007, Chemical reviews.

[25]  Xiaoju Wang,et al.  Highly selective recognition of monosaccharide based on two-component system in aqueous solution , 2011 .