Induction of humoral and enhanced cellular immune responses by novel core-shell nanosphere- and microsphere-based vaccine formulations following systemic and mucosal administration.
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G. Altavilla | R. Gavioli | A. Caputo | B. Ensoli | L. Tondelli | K. Sparnacci | M. Laus | R. Voltan | Arianna Castaldello | E. Brocca-Cofano | F. Bortolazzi
[1] P. Narciso,et al. The therapeutic phase I trial of the recombinant native HIV-1 Tat protein , 2008, AIDS.
[2] A. Caputo,et al. Functional polymeric nano/microparticles for surface adsorption and delivery of protein and DNA vaccines. , 2008, Current drug delivery.
[3] R. Gavioli,et al. Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin. , 2008, Vaccine.
[4] R. Gavioli,et al. The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: implications for the design of new vaccination strategies against AIDS. , 2008, Vaccine.
[5] T. Delair,et al. Formulation of HIV-1 Tat and p24 antigens by PLA nanoparticles or MF59 impacts the breadth, but not the magnitude, of serum and faecal antibody responses in rabbits. , 2007, Vaccine.
[6] Sai T Reddy,et al. Exploiting lymphatic transport and complement activation in nanoparticle vaccines , 2007, Nature Biotechnology.
[7] M. Magnani,et al. Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge. , 2007, Vaccine.
[8] G. Altavilla,et al. Preparation and Characterization of Innovative Protein-coated Poly(Methylmethacrylate) Core-shell Nanoparticles for Vaccine Purposes , 2007, Pharmaceutical Research.
[9] M. Robert-Guroff,et al. Problems and emerging approaches in HIV/AIDS vaccine development , 2007, Expert opinion on emerging drugs.
[10] M. Magnani,et al. Candidate HIV-1 Tat vaccine development: from basic science to clinical trials. , 2006, AIDS.
[11] M. Houghton,et al. Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses. , 2006, The Journal of general virology.
[12] L. Kwak,et al. Prophylactic anti-tumor effects in a B cell lymphoma model with DNA vaccines delivered on polyethylenimine (PEI) functionalized PLGA microparticles. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[13] Giuseppe Altavilla,et al. DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination. , 2006, Vaccine.
[14] Y. Perrie,et al. Particulate delivery systems for vaccines: what can we expect? , 2006, The Journal of pharmacy and pharmacology.
[15] Roger Le Grand,et al. Surfactant-free anionic PLA nanoparticles coated with HIV-1 p24 protein induced enhanced cellular and humoral immune responses in various animal models. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[16] R. Mumper,et al. HIV-1 Tat-coated nanoparticles result in enhanced humoral immune responses and neutralizing antibodies compared to alum adjuvant. , 2006, Vaccine.
[17] S. Davis. The use of soluble polymers and polymer microparticles to provide improved vaccine responses after parenteral and mucosal delivery. , 2006, Vaccine.
[18] B. Ensoli,et al. Efficient systemic and mucosal responses against the HIV-1 Tat protein by prime/boost vaccination using the lipopeptide MALP-2 as adjuvant. , 2006, Vaccine.
[19] Manmohan J. Singh,et al. A preliminary evaluation of alternative adjuvants to alum using a range of established and new generation vaccine antigens. , 2006, Vaccine.
[20] S. Kasturi,et al. Covalent conjugation of polyethyleneimine on biodegradable microparticles for delivery of plasmid DNA vaccines. , 2005, Biomaterials.
[21] I. Sjöholm,et al. Starch microparticles as vaccine adjuvant , 2005, Expert opinion on drug delivery.
[22] L. Barbu-Tudoran,et al. Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination. , 2005, Journal of controlled release : official journal of the Controlled Release Society.
[23] B. Frisch,et al. Effect of synthetic lipopeptides formulated in liposomes on the maturation of human dendritic cells. , 2005, Molecular immunology.
[24] Hans P Merkle,et al. Formulation aspects of biodegradable polymeric microspheres for antigen delivery. , 2005, Advanced drug delivery reviews.
[25] M. Marchisio,et al. Core–shell microspheres by dispersion polymerization as promising delivery systems for proteins , 2005, Journal of biomaterials science. Polymer edition.
[26] M. Houghton,et al. Cationic microparticles are a potent delivery system for a HCV DNA vaccine. , 2004, Vaccine.
[27] Manmohan J. Singh,et al. Adsorption of a Novel Recombinant Glycoprotein from HIV (Env gp120dV2 SF162) to Anionic PLG Microparticles Retains the Structural Integrity of the Protein, Whereas Encapsulation in PLG Microparticles Does Not , 2004, Pharmaceutical Research.
[28] B. Ensoli,et al. Nonstructural HIV proteins as targets for prophylactic or therapeutic vaccines. , 2004, Current opinion in biotechnology.
[29] R. Gavioli,et al. Recent advances in the development of HIV-1 Tat-based vaccines. , 2004, Current HIV research.
[30] J. Heeney,et al. Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys. , 2004, Vaccine.
[31] G. Altavilla,et al. Novel biocompatible anionic polymeric microspheres for the delivery of the HIV-1 Tat protein for vaccine application. , 2004, Vaccine.
[32] Russell J Mumper,et al. Strong T cell type-1 immune responses to HIV-1 Tat (1-72) protein-coated nanoparticles. , 2004, Vaccine.
[33] D. Sesardic,et al. European union regulatory developments for new vaccine adjuvants and delivery systems. , 2004, Vaccine.
[34] Jayanth Panyam,et al. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[35] M. Marinaro,et al. Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes and mucosal IgA. , 2003, Vaccine.
[36] A. Scoglio,et al. Efficient mucosal delivery of the HIV‐1 Tat protein using the synthetic lipopeptide MALP‐2 as adjuvant , 2003, European journal of immunology.
[37] Manmohan J. Singh,et al. Microparticles as vaccine adjuvants and delivery systems , 2003, Expert review of vaccines.
[38] Giuseppe Del Giudice,et al. MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile , 2003, Expert review of vaccines.
[39] G. Altavilla,et al. Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers induces CTL responses against Tat. , 2003, Vaccine.
[40] Thomas Kissel,et al. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. , 2003, Biomaterials.
[41] S. Moretti,et al. Native HIV-1 Tat Protein Targets Monocyte-Derived Dendritic Cells and Enhances Their Maturation, Function, and Antigen-Specific T Cell Responses1 , 2002, The Journal of Immunology.
[42] J. Ulmer,et al. Induction of Potent Immune Responses by Cationic Microparticles with Adsorbed Human Immunodeficiency Virus DNA Vaccines , 2001, Journal of Virology.
[43] G. Ott,et al. Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1. , 2000, Journal of controlled release : official journal of the Controlled Release Society.
[44] Manmohan J. Singh,et al. Cationic microparticles: A potent delivery system for DNA vaccines. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[45] Manmohan J. Singh,et al. Advances in vaccine adjuvants , 1999, Nature Biotechnology.
[46] A. Coombes,et al. Potential of polymeric lamellar substrate particles (PLSP) as adjuvants for vaccines. , 1999, Vaccine.
[47] J. Heeney,et al. Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine , 1999, Nature Medicine.
[48] C. Rossi,et al. DNA immunization with HIV-1 tat mutated in the trans activation domain induces humoral and cellular immune responses against wild-type Tat. , 1999, Journal of immunology.
[49] H. Sah. Stabilization of proteins against methylene chloride/water interface-induced denaturation and aggregation. , 1999, Journal of controlled release : official journal of the Controlled Release Society.
[50] Gupta,et al. Aluminum compounds as vaccine adjuvants. , 1998, Advanced drug delivery reviews.
[51] Langer,et al. New advances in microsphere-based single-dose vaccines. , 1997, Advanced drug delivery reviews.
[52] P. Wingfield,et al. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation , 1993, Journal of virology.
[53] 廷冕 李,et al. 応用 (Application) について , 1981 .
[54] Manmohan J. Singh,et al. Polylactide-co-glycolide microparticles with surface adsorbed antigens as vaccine delivery systems. , 2006, Current drug delivery.
[55] P van Hoogevest,et al. MF59. Design and evaluation of a safe and potent adjuvant for human vaccines. , 1995, Pharmaceutical biotechnology.