Inhibitory Function in Nonretarded Children with Autism

This study examined inhibitory function in nonretarded children with autism (n = 13) and normally developing controls (n = 13) matched on age and IQ. Tasks measuring motor and cognitive components of inhibition were administered to both groups. On the Stop-Signal paradigm, children with autism were able to inhibit motor responses to neutral and prepotent stimuli as well as control subjects. On the Negative Priming task, the groups were equally capable of inhibiting processing of irrelevant distractor stimuli in a visual display. Results suggest that at least two components of inhibition are spared in individuals with autism, standing in contrast to flexibility and other executive deficits that have been found in previous studies. These findings may help distinguish children with autism from those with other neurodevelopmental conditions that involve executive dysfunction.

[1]  S. Tipper,et al.  A model of inhibitory mechanisms in selective attention. , 1994 .

[2]  J. Ducharme,et al.  Variables influencing stimulus overselectivity and "tunnel vision" in developmentally delayed children. , 1987, American journal of mental deficiency.

[3]  L. Schreibman,et al.  Stimulus overselectivity in autism: a review of research. , 1979, Psychological bulletin.

[4]  D. A. Grant,et al.  A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. , 1948, Journal of experimental psychology.

[5]  G. Logan,et al.  Impulsivity and Inhibitory Control in Normal Development and Childhood Psychopathology , 1990 .

[6]  J. Rumsey.  Conceptual problem-solving in highly verbal, nonretarded autistic men , 1985, Journal of autism and developmental disorders.

[7]  Ajw Vanderdoes,et al.  WHAT DETERMINES WISCONSIN CARD SORTING PERFORMANCE IN SCHIZOPHRENIA , 1992 .

[8]  B. Pennington,et al.  Executive function deficits in high-functioning autistic individuals: relationship to theory of mind. , 1991, Journal of child psychology and psychiatry, and allied disciplines.

[9]  James A. Russell,et al.  Autistic children's difficulty with mental disengagement from an object: Its implications for theories of autism. , 1993 .

[10]  Hans Colonius,et al.  A Note on the Stop-Signal Paradigm, or How to Observe the Unobservable , 1990 .

[11]  H. Kucera,et al.  Computational analysis of present-day American English , 1967 .

[12]  G. Logan,et al.  On the ability to inhibit simple and choice reaction time responses: a model and a method. , 1984, Journal of experimental psychology. Human perception and performance.

[13]  Dc Washington.  Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. , 1994 .

[14]  P. Lachenbruch.  Statistical Power Analysis for the Behavioral Sciences (2nd ed.) , 1989 .

[15]  P. Szatmari,et al.  Asperger's syndrome and autism: neurocognitive aspects. , 1990, Journal of the American Academy of Child and Adolescent Psychiatry.

[16]  Bruce F. Pennington,et al.  Executive functions and working memory: Theoretical and measurement issues. , 1996 .

[17]  J. Rumsey,et al.  Neuropsychological divergence of high-level autism and severe dyslexia , 1990, Journal of autism and developmental disorders.

[18]  A. Beech,et al.  Evidence of reduced 'cognitive inhibition' in schizophrenia. , 1989, The British journal of clinical psychology.

[19]  E. Feigenbaum.  13 – Information Processing and Memory , 1970 .

[20]  S. Ozonoff.  Executive Functions in Autism , 1995 .

[21]  B. Pennington,et al.  Executive function and social communication deficits in young autistic children. , 1993, Journal of child psychology and psychiatry, and allied disciplines.

[22]  A. Beech,et al.  Reduced cognitive inhibition in obsessive-compulsive disorder. , 1993, The British journal of clinical psychology.

[23]  W. Neill,et al.  Negative priming insame-different matching: Further evidence for a central locus of inhibition , 1990, Perception & psychophysics.

[24]  Bruce F. Pennington,et al.  The working memory function of the prefrontal cortices: Implications for developmental and individual differences in cognition. , 1994 .

[25]  Jacob Cohen.  Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[26]  S. Ozonoff.  Reliability and validity of the Wisconsin Card Sorting Test in studies of autism. , 1995 .

[27]  J. Changeux,et al.  The Wisconsin Card Sorting Test: theoretical analysis and modeling in a neuronal network. , 1991, Cerebral cortex.

[28]  K. Perrine,et al.  Differential aspects of conceptual processing in the Category Test and Wisconsin Card Sorting Test. , 1993, Journal of clinical and experimental neuropsychology.

[29]  R. Heaton.  Wisconsin Card Sorting Test manual , 1993 .

[30]  M. Prior,et al.  Brief report: Neuropsychological testing of autistic children through an exploration with frontal lobe tests , 1990, Journal of autism and developmental disorders.

[31]  J. Rumsey,et al.  Neuropsychological findings in high-functioning men with infantile autism, residual state. , 1988, Journal of clinical and experimental neuropsychology.

[32]  David L. Strayer,et al.  Executive function abilities in autism and Tourette syndrome: an information processing approach. , 1994, Journal of child psychology and psychiatry, and allied disciplines.

[33]  S. Bryson,et al.  Chapter 21 Autism: A Developmental Spatial Neglect Syndrome? , 1990 .

[34]  H. Buchtel,et al.  Comparison of the Wisconsin Card Sorting Test and the Halstead Category Test. , 1984, Journal of clinical psychology.

[35]  S. Ozonoff,et al.  A longitudinal study of executive function and theory of mind development in autism , 1994, Development and Psychopathology.

[36]  S. Tipper.  The Negative Priming Effect: Inhibitory Priming by Ignored Objects , 1985, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[37]  J. Russell,et al.  Evidence for executive dysfunction in autism , 1994, Neuropsychologia.