The effect of non-activated prothrombin complex concentrate (Proplex ST) on intraperitoneal hematoma in a hemophilia A patient with a factor VIII inhibitor.

A 28-year-old severe hemophiliac with a factor VIII inhibitor was admitted to our hospital with a massive and serious intraperitoneal hematoma. He was a high-responder patient showing maximal serum inhibitor levels as high as 255 Bethesda Units/ml (BU/ml). He was successfully treated with "bypass therapy" using a prothrombin complex concentrate (PCC).

[1]  J. Takamatsu,et al.  Clinical Study of Recombinant Factor VIIa (NN-007) in Hemophilia Patients with Inhibitors , 1994 .

[2]  W. Kreuz,et al.  Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs , 1992, The Lancet.

[3]  U. Hedner.  Factor VIIa in the treatment of haemophilia. , 1990, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[4]  Masakazu Ishikawa,et al.  Pyloric ring, pancreas and papilla-saving subtotal duodenectomy for a duodenal submucosal hematoma in a patient with hemophilia. , 1990 .

[5]  J. Tovar,et al.  Giant spontaneous duodenal hematoma in hemophilia A. , 1989, Journal of pediatric surgery.

[6]  M. Fujimaki.  [Treatment of hemophiliacs with inhibitors]. , 1985, [Rinsho ketsueki] The Japanese journal of clinical hematology.

[7]  S. Okubo,et al.  [Studies on the usefulness of double filtration plasmapheresis in a hemophilia A patient with anti-factor VIII antibody (inhibitor)]. , 1985, [Rinsho ketsueki] The Japanese journal of clinical hematology.

[8]  H. Roberts.  Hemophiliacs with inhibitors: therapeutic options. , 1981, The New England journal of medicine.

[9]  H. V. van Houwelingen,et al.  The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to factor VIII. A double-blind clinical trial. , 1981, The New England journal of medicine.

[10]  A. Yoshioka,et al.  Laboratory evidence of DIC under FEIBA treatment of a hemophilic patient with intracranial bleeding and high titre factor VIII inhibitor. , 1981, Thrombosis research.

[11]  A. Yoshioka,et al.  Management of bleeding episodes with factor VIII concentrates in hemophiliacs with low titre inhibitor , 1980 .

[12]  G. Buchanan,et al.  Use of prothrombin complex concentrates in hemophiliacs with inhibitors: clinical and laboratory studies. , 1978, Pediatrics.

[13]  S. Shapiro,et al.  Heterogeneity of factor VIII antibodies: further immunochemical and biologic studies. , 1977, Blood.

[14]  I. Nilsson,et al.  Immunosuppressive treatment in haemophiliacs with inhibitors to factor VIII and factor IX. , 2009, Scandinavian journal of haematology.

[15]  S. Shapiro,et al.  Immunosuppressive therapy of Factor VIII inhibitors , 1976 .

[16]  A. Cederbaum,et al.  Intravascular coagulation with use of human prothrombin complex concentrates. , 1976, Annals of internal medicine.

[17]  J. Allain,et al.  PROTHROMBIN-COMPLEX CONCENTRATE IN TREATMENT OF CLASSICAL HÆMOPHILIA WITH FACTOR-VIII ANTIBODY , 1975, The Lancet.