Curve Tracking for Rapid Imaging in AFM

A high-level feedback control approach for rapid imaging in atomic force microscopy is presented. The algorithms are designed for samples which are string-like, such as biopolymers, and for boundaries. Rather than the simple raster-scan pattern, data from the microscope are used in real-time to steer the tip along the sample, drastically reducing the area to be imaged. An order-of-magnitude reduction in the time to acquire an image is possible. The technique is illustrated through simulations and through physical experiments.

[1]  Miguel A R B Castanho,et al.  An overview of the biophysical applications of atomic force microscopy. , 2003, Biophysical chemistry.

[2]  Joshua W. Shaevitz,et al.  Backtracking by single RNA polymerase molecules observed at near-base-pair resolution , 2003, Nature.

[3]  Fumin Zhang,et al.  Experimental study of curvature-based control laws for obstacle avoidance , 2004, IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004.

[4]  P. S. Krishnaprasad,et al.  Equilibria and steering laws for planar formations , 2004, Syst. Control. Lett..

[5]  T. Ando,et al.  A high-speed atomic force microscope for studying biological macromolecules , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Murti V. Salapaka,et al.  Transient-signal-based sample-detection in atomic force microscopy , 2003 .

[7]  F. Allgöwer,et al.  High performance feedback for fast scanning atomic force microscopes , 2001 .

[8]  P K Hansma,et al.  Escherichia coli RNA polymerase activity observed using atomic force microscopy. , 1997, Biochemistry.

[9]  J. Loos,et al.  The Art of SPM: Scanning Probe Microscopy in Materials Science , 2005 .

[10]  J. G. Elias,et al.  The dimensions of DNA in solution. , 1981, Journal of molecular biology.

[11]  Naomi Ehrich Leonard,et al.  Generating contour plots using multiple sensor platforms , 2005, Proceedings 2005 IEEE Swarm Intelligence Symposium, 2005. SIS 2005..

[12]  Jiwoong Park,et al.  Tip steering for fast imaging in AFM , 2005, Proceedings of the 2005, American Control Conference, 2005..

[13]  D. Lilley,et al.  DNA replication, 2nd edn , 1992 .

[14]  H. Hansma.  Surface biology of DNA by atomic force microscopy. , 2001, Annual review of physical chemistry.

[15]  U Aebi,et al.  Monitoring biomolecular interactions by time-lapse atomic force microscopy. , 2000, Journal of structural biology.

[16]  Increasing shear force microscopy scanning rate using active quality-factor control , 2003 .

[17]  Demetri Terzopoulos,et al.  Snakes: Active contour models , 2004, International Journal of Computer Vision.

[18]  Todd Sulchek,et al.  High-speed tapping mode imaging with active Q control for atomic force microscopy , 2000 .

[19]  Sanjay Kumar,et al.  Probing the Machinery of Intracellular Trafficking with the Atomic Force Microscope , 2001, Traffic.

[20]  Tiina Lehto,et al.  Observing structure, function and assembly of single proteins by AFM. , 2002, Progress in biophysics and molecular biology.

[21]  Mekhail Anwar,et al.  Atomic force microscopy with time resolution of microseconds , 2005 .

[22]  C. Bustamante,et al.  Following the assembly of RNA polymerase-DNA complexes in aqueous solutions with the scanning force microscope. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Y. Dufrêne,et al.  Advances in the characterization of supported lipid films with the atomic force microscope. , 2000, Biochimica et biophysica acta.

[24]  A. Stemmer,et al.  Fast contact-mode atomic force microscopy on biological specimen by model-based control. , 2004, Ultramicroscopy.

[25]  F. Bullo,et al.  Monitoring environmental boundaries with a robotic sensor network , 2006 .

[26]  Jerome Mertz,et al.  Regulation of a microcantilever response by force feedback , 1993 .

[27]  Eric W. Justh,et al.  Boundary following using gyroscopic control , 2004, 2004 43rd IEEE Conference on Decision and Control (CDC) (IEEE Cat. No.04CH37601).

[28]  Paul K. Hansma,et al.  Fast imaging and fast force spectroscopy of single biopolymers with a new atomic force microscope designed for small cantilevers , 1999 .

[29]  Steven Haker,et al.  Differential and Numerically Invariant Signature Curves Applied to Object Recognition , 1998, International Journal of Computer Vision.

[30]  Ami Chand,et al.  Probing protein–protein interactions in real time , 2000, Nature Structural Biology.

[31]  I. Larson,et al.  Atomic force microscopy and direct surface force measurements (IUPAC Technical Report) , 2005 .

[32]  B G de Grooth,et al.  High speed atomic force microscopy of biomolecules by image tracking. , 1999, Biophysical journal.

[33]  Y. Lyubchenko.  DNA structure and dynamics , 2007, Cell Biochemistry and Biophysics.

[34]  E. Winfree,et al.  Algorithmic Self-Assembly of DNA Sierpinski Triangles , 2004, PLoS biology.

[35]  Fei Philip Gao,et al.  AFM visualization of mobile influenza A M2 molecules in planar bilayers. , 2004, Biophysical journal.