PANCREATIC ADENOSQUAMOUS CARCINOMA (PASC): REPORT OF TWO CASES WITH AUTOPSY

We report two cases of pancreatic adenosquamous carcinoma (PASC) with autopsy findings. Case 1: A 83―year―old woman was admitted to our hospital complaining of general fatigue and appetite loss. Based on imaging studies, the diagnosis of pancreatic head cancer with liver metastasis was made. The clinical course was extremely rapid, and the patient died one month after admission. The autopsy revealed that the pancreatic head cancer directly invaded the duodenum. Pathologically, three fourths of the tumor consisted of poorly differentiated squamous cell carcinoma and one fourth moderately differentiated tubular adenocarcinoma, and the mass was diagnosed to be PASC. Case 2: A 75―year―old woman was fol-lowed for autoimmune hepatitis by our hospital, and was admitted due to general fatigue. Several diag-nostic modalities revealed a retroperitoneal tumor invading the left kidney with liver and adrenal metastasis. The general state was already poor and the patient died one month later. The autopsy revealed that the pancreatic body cancer directly invaded the posterior wall of the stomach, the transverse colon, the oral side of the jejunum, the spleen, and the left kidney. Pathological findings revealed that the mass consisted predominantly of spindle cell and solid proliferating components containing small foci of moderately differentiated tubular adenocarcinoma in the hilus of the spleen.