Signal Transduction and Cardiac Hypertrophy

[1]  S. Ogawa,et al.  Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK/STAT pathway in rodent heart , 2005, Heart and Vessels.

[2]  R. Ross,et al.  Integrins and the myocardium. , 2001, Genetic engineering.

[3]  Keiji Naruse,et al.  Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation. , 2001, Biochemical and biophysical research communications.

[4]  N. Maulik,et al.  JAK/STAT Signaling Is Associated With Cardiac Dysfunction During Ischemia and Reperfusion , 2001, Circulation.

[5]  Jiang Chang,et al.  Activation of Heat-Shock Factor by Stretch-Activated Channels in Rat Hearts , 2001, Circulation.

[6]  C. Pham,et al.  Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. , 2001, The American journal of pathology.

[7]  J. Molkentin,et al.  The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo , 2001, Circulation research.

[8]  G. Dorn,et al.  Cytoplasmic signaling pathways that regulate cardiac hypertrophy. , 2001, Annual review of physiology.

[9]  C. Pham,et al.  Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. , 2000, American journal of physiology. Heart and circulatory physiology.

[10]  J. D’Armiento,et al.  Disruption of the myocardial extracellular matrix leads to cardiac dysfunction. , 2000, The Journal of clinical investigation.

[11]  Tyagi.  Physiology and homeostasis of extracellular matrix: cardiovascular adaptation and remodeling. , 2000, Pathophysiology : the official journal of the International Society for Pathophysiology.

[12]  K. Webster,et al.  Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis. , 2000, The American journal of pathology.

[13]  S. Popov,et al.  Regulators of G-protein signaling in receptor complexes. , 2000, Trends in cardiovascular medicine.

[14]  D. Gardner,et al.  Integrin Dependence of Brain Natriuretic Peptide Gene Promoter Activation by Mechanical Strain* , 2000, The Journal of Biological Chemistry.

[15]  C. Ruwhof,et al.  Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. , 2000, Cardiovascular research.

[16]  E. Rubin,et al.  Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[17]  R. A. Hunt,et al.  Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3 : an autocrine loop for hypertrophy. , 2000, Hypertension.

[18]  A. Clerk,et al.  Small guanine nucleotide-binding proteins and myocardial hypertrophy. , 2000, Circulation research.

[19]  J. Dyck,et al.  Identification of genes regulated during mechanical load-induced cardiac hypertrophy. , 2000, Journal of molecular and cellular cardiology.

[20]  W. Schaper,et al.  Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium. , 2000, Circulation research.

[21]  M. Okabe,et al.  Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Humphries,et al.  Integrin structure. , 2000, Biochemical Society transactions.

[23]  D. Gardner,et al.  Endothelin-dependent and -independent components of strain-activated brain natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen-activated protein kinase. , 2000, Hypertension.

[24]  A. Clerk,et al.  Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists. , 2000, Trends in cardiovascular medicine.

[25]  A. Ridley.  Rho GTPases: Integrating Integrin Signaling , 2000 .

[26]  D. Gardner,et al.  Mechanical strain activates BNP gene transcription through a p38/NF-kappaB-dependent mechanism. , 1999, The Journal of clinical investigation.

[27]  K. Fujimoto,et al.  Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts. , 1999, Circulation research.

[28]  T. Borg,et al.  Regulation of cardiac myocyte protein turnover and myofibrillar structure in vitro by specific directions of stretch. , 1999, Circulation research.

[29]  Kenji Sugiyama,et al.  JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway , 1999, Molecular and Cellular Biology.

[30]  J. Heino,et al.  Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic Tail , 1999, The Journal of cell biology.

[31]  Qingbo Xu,et al.  Cyclic Strain Stress-induced Mitogen-activated Protein Kinase (MAPK) Phosphatase 1 Expression in Vascular Smooth Muscle Cells Is Regulated by Ras/Rac-MAPK Pathways* , 1999, The Journal of Biological Chemistry.

[32]  J. Guerrero,et al.  Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases. , 1999, The Journal of clinical investigation.

[33]  S. Cook,et al.  Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease. , 1999, Journal of molecular and cellular cardiology.

[34]  J. Sadoshima,et al.  Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. , 1999, Circulation research.

[35]  M. Zile,et al.  Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices. , 1999, The American journal of cardiology.

[36]  MotoakiSano,et al.  Mechanical Stretch Activates the JAK/STAT Pathway in Rat Cardiomyocytes , 1999 .

[37]  Y. Yazaki,et al.  Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. , 1999, Biochemical and biophysical research communications.

[38]  J. Downward,et al.  Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf. , 1998, The Biochemical journal.

[39]  Shokei Kim,et al.  Differential activation of cardiac c-jun amino-terminal kinase and extracellular signal-regulated kinase in angiotensin II-mediated hypertension. , 1998, Circulation research.

[40]  R. Hajjar,et al.  Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy. , 1998, The Journal of clinical investigation.

[41]  Mark A Sussman,et al.  Prevention of cardiac hypertrophy in mice by calcineurin inhibition. , 1998, Science.

[42]  Y. Zou,et al.  Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice. , 1998, The Journal of biological chemistry.

[43]  K. Tanaka,et al.  A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. , 1998, The Journal of clinical investigation.

[44]  Takako Yamada,et al.  Pp125FAK is required for stretch dependent morphological response of endothelial cells , 1998, Oncogene.

[45]  M. Moran,et al.  The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways , 1998, Current Biology.

[46]  Y. Fujio,et al.  Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. , 1998, Circulation.

[47]  A. Clerk,et al.  Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein–coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy? , 1998, The Journal of cell biology.

[48]  Jiahuai Han,et al.  The p38 MAP kinase pathway and its biological function. , 1998, Trends in cardiovascular medicine.

[49]  Y. Toya,et al.  Activation of angiotensinogen gene in cardiac myocytes by angiotensin II and mechanical stretch. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[50]  A. Lin,et al.  Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy , 1998, Molecular and Cellular Biology.

[51]  K. Kikuchi,et al.  Mechanical stretch activates a pathway linked to mevalonate metabolism in cultured neonatal rat heart cells. , 1998, Hypertension research : official journal of the Japanese Society of Hypertension.

[52]  A. Aplin,et al.  Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. , 1998, Pharmacological reviews.

[53]  L. Coppey,et al.  Activation of JNK in the remote myocardium after large myocardial infarction in rats. , 1998, Biochemical and biophysical research communications.

[54]  M. Siddiqui,et al.  Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[55]  J. Frangos,et al.  Equibiaxial strain and strain rate stimulate early activation of G proteins in cardiac fibroblasts. , 1998, American journal of physiology. Cell physiology.

[56]  R. Lefkowitz,et al.  Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. , 1998, Science.

[57]  Jeffrey Robbins,et al.  A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy , 1998, Cell.

[58]  K. Baker,et al.  Angiotensin II activates Stat5 through Jak2 kinase in cardiac myocytes. , 1998, Journal of molecular and cellular cardiology.

[59]  Q. Li,et al.  Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. , 1998, The Journal of clinical investigation.

[60]  A. Thorburn,et al.  Ras and rho are required for galphaq-induced hypertrophic gene expression in neonatal rat cardiac myocytes. , 1998, Journal of molecular and cellular cardiology.

[61]  S. Ogawa,et al.  Biphasic activation of the JAK/STAT pathway by angiotensin II in rat cardiomyocytes. , 1998, Circulation research.

[62]  J Ross,et al.  Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family* , 1998, The Journal of Biological Chemistry.

[63]  P. Cohen,et al.  Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 rsk That Are Inducible by MAPK* , 1998, The Journal of Biological Chemistry.

[64]  E Ruoslahti,et al.  Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. , 1998, The Journal of clinical investigation.

[65]  C. Pham,et al.  Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes. , 1998, Circulation research.

[66]  W. Hsueh,et al.  Integrins, adhesion, and cardiac remodeling. , 1998, Hypertension.

[67]  M. Garami,et al.  Mechanical Strain Increases Expression of the Brain Natriuretic Peptide Gene in Rat Cardiac Myocytes* , 1997, The Journal of Biological Chemistry.

[68]  S. Ogawa,et al.  Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. , 1997, Circulation research.

[69]  P. Cohen,et al.  The search for physiological substrates of MAP and SAP kinases in mammalian cells. , 1997, Trends in cell biology.

[70]  R. A. Hunt,et al.  The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes. , 1997, Journal of molecular and cellular cardiology.

[71]  R. Davis,et al.  Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[72]  A. Kraft,et al.  Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells* , 1997, The Journal of Biological Chemistry.

[73]  A. Fukamizu,et al.  Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. , 1997, Biochemical and biophysical research communications.

[74]  N. Tonks,et al.  Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes. , 1997, The Biochemical journal.

[75]  George Cooper,et al.  Association of Tyrosine-phosphorylated c-Src with the Cytoskeleton of Hypertrophying Myocardium* , 1997, The Journal of Biological Chemistry.

[76]  M. Abdellatif,et al.  An Effector-like Function of Ras GTPase-activating Protein Predominates in Cardiac Muscle Cells* , 1997, The Journal of Biological Chemistry.

[77]  R. Fässler,et al.  Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. , 1996, Journal of cell science.

[78]  IsseiKomuro,et al.  Mechanical Stretch Induces Enhanced Expression of Angiotensin II Receptor Subtypes in Neonatal Rat Cardiac Myocytes , 1996 .

[79]  J. Le Guennec,et al.  A possible mechanism for large stretch-induced increase in [Ca2+]i in isolated guinea-pig ventricular myocytes. , 1996, Cardiovascular research.

[80]  K. Kikuchi,et al.  Renin-angiotensin system in stretch-induced hypertrophy of cultured neonatal rat heart cells. , 1996, European journal of pharmacology.

[81]  Y. Yazaki,et al.  Mechanical stretch activates the stress‐activated protein kinase in cardiac myocytes , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[82]  C. Der,et al.  The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation (*) , 1996, The Journal of Biological Chemistry.

[83]  K. Chien,et al.  Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. , 1996, The Journal of biological chemistry.

[84]  J. Ihle.  Cytokine receptor signalling , 1995, Nature.

[85]  Y. Zou,et al.  Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. , 1995, Circulation research.

[86]  Y. Zou,et al.  Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. , 1995, The Journal of clinical investigation.

[87]  D. Dostal,et al.  Sensitive bioassay for the detection and quantification of angiotensin II in tissue culture medium. , 1995, BioTechniques.

[88]  A. Corbier,et al.  Fibronectin expression during physiological and pathological cardiac growth. , 1995, Journal of molecular and cellular cardiology.

[89]  S. Keyse.  An emerging family of dual specificity MAP kinase phosphatases. , 1995, Biochimica et biophysica acta.

[90]  J. Darnell,et al.  Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. , 1995, Annual review of biochemistry.

[91]  R. Mayne,et al.  Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle. , 1995, Biochemical and biophysical research communications.

[92]  A. Sonnenberg,et al.  A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle. , 1995, FEBS letters.

[93]  B. Carabello,et al.  Acute changes in myosin heavy chain synthesis rate in pressure versus volume overload. , 1994, Circulation research.

[94]  K. Guan,et al.  The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. , 1994, Cellular signalling.

[95]  J. Le Guennec,et al.  Streptomycin reverses a large stretch induced increases in [Ca2+]i in isolated guinea pig ventricular myocytes. , 1994, Cardiovascular research.

[96]  W. Seed,et al.  Effects of gadolinium on length‐dependent force in guinea‐pig papillary muscle , 1994, Experimental physiology.

[97]  J. Sadoshima,et al.  Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro , 1993, Cell.

[98]  R. Davis,et al.  The mitogen-activated protein kinase signal transduction pathway. , 1993, The Journal of biological chemistry.

[99]  R. Nagai,et al.  Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. , 1993, The Journal of biological chemistry.

[100]  J. Sadoshima,et al.  Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. , 1993, The EMBO journal.

[101]  S. Powers,et al.  HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. , 1993, The Journal of biological chemistry.

[102]  David Stokoe,et al.  Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins , 1992, FEBS letters.

[103]  F. Sachs,et al.  Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels. , 1992, The American journal of physiology.

[104]  J. Schaper,et al.  The extracellular matrix in the failing human heart. , 1992, Basic research in cardiology.

[105]  B. Swynghedauw.  Biological adaptation of the myocardium to a permanent change in loading conditions. , 1992, Basic research in cardiology.

[106]  Nancy Y. Ip,et al.  ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF , 1991, Cell.

[107]  T K Borg,et al.  Expression of collagen binding integrins during cardiac development and hypertrophy. , 1991, Circulation research.

[108]  Y. Yazaki,et al.  Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation. , 1991, The Journal of biological chemistry.

[109]  J. Ingwall,et al.  Regional changes in creatine kinase and myocyte size in hypertensive and nonhypertensive cardiac hypertrophy. , 1990, Circulation research.

[110]  T. Borg,et al.  Distribution of vinculin in the Z‐disk of striated muscle: Analysis by laser scanning confocal microscopy , 1990, Journal of cellular physiology.

[111]  G. Cooper.  Cardiocyte adaptation to chronically altered load. , 1987, Annual review of physiology.

[112]  T. Borg,et al.  Recognition of extracellular matrix components by neonatal and adult cardiac myocytes. , 1984, Developmental biology.

[113]  P. Hatt,et al.  Morphometry and ultrastructure of heart hypertrophy induced by chronic volume overload (aorto-caval fistula in the rat). , 1979, Journal of molecular and cellular cardiology.

[114]  R. Satava,et al.  Mechanism for the Abnormal Energetics of Pressure‐Induced Hypertrophy of Cat Myocardium , 1973, Circulation research.