Potential Effects of Traditional Chinese Medicine in Anti-Aging and Aging-Related Diseases: Current Evidence and Perspectives

Abstract Aging and aging-related diseases present a global public health problem. Therefore, the development of efficient anti-aging drugs has become an important area of research. Traditional Chinese medicine is an important complementary and alternative branch of aging-related diseases therapy. Recently, a growing number of studies have revealed that traditional Chinese medicine has a certain delaying effect on the progression of aging and aging-related diseases. Here, we review the progress in research into using traditional Chinese medicine for aging and aging-related diseases (including neurodegenerative diseases, cardiovascular diseases, diabetes, and cancer). Furthermore, we summarize the potential mechanisms of action of traditional Chinese medicine and provide references for further studies on aging and aging-related diseases.

[1]  Lan Xiang,et al.  Involvement of the Sch9/Rim15/Msn2 signaling pathway in the anti-aging activity of dendrobine from Dendrobium nobile Lindl. via modification of oxidative stress and autophagy , 2023, Chinese Medicine.

[2]  Sha Zhu,et al.  Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expression. , 2023, Journal of ethnopharmacology.

[3]  Zhonghong Wei,et al.  Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2/PGE2 cascade. , 2023, Journal of ethnopharmacology.

[4]  Xu‐Jie Zhang,et al.  Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice , 2023, Korean Journal of Physiology and Pharmacology.

[5]  Wuyang Wang,et al.  Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro. , 2023, Journal of ethnopharmacology.

[6]  Yunlong Hou,et al.  Bazi Bushen mitigates epigenetic aging and extends healthspan in naturally aging mice. , 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[7]  W. Lam,et al.  YIV-906 enhances nuclear factor of activated T-cells (NFAT) activity of T cells and promotes immune checkpoint blockade antibody action and CAR T-cell activity , 2023, Frontiers in Pharmacology.

[8]  Can-Xing Yuan,et al.  Traditional Chinese medicine Pingchan granule for motor symptoms and functions in Parkinson's disease: A multicenter, randomized, double-blind, placebo-controlled study. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[9]  Jiao Guo,et al.  Ginsenoside Rb1 improves intestinal aging via regulating the expression of sirtuins in the intestinal epithelium and modulating the gut microbiota of mice , 2022, Frontiers in Pharmacology.

[10]  Zhongqi Shen,et al.  Network Pharmacology and Molecular Docking Analyses Unveil the Mechanisms of Yiguanjian Decoction against Parkinson's Disease from Inner/Outer Brain Perspective , 2022, BioMed research international.

[11]  W. Wang,et al.  Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis , 2022, Oxidative medicine and cellular longevity.

[12]  M. Dai,et al.  Deciphering the combination mechanisms of Gualou–Xiebai herb pair against atherosclerosis by network pharmacology and HPLC-Q-TOF-MS technology , 2022, Frontiers in Pharmacology.

[13]  Yingying Shen,et al.  Neobavaisoflavone inhibits antitumor immunosuppression via myeloid-derived suppressor cells. , 2022, International immunopharmacology.

[14]  X. Qin,et al.  Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria , 2022, Frontiers in aging neuroscience.

[15]  Yingchun He,et al.  Sinomenine exerts a neuroprotective effect on PD mouse model through inhibiting PI3K/AKT/mTOR pathway to enhance autophagy , 2022, The International journal of neuroscience.

[16]  Jiandong Lu,et al.  Jian-Pi-Yi-Shen Formula Improves Adenine-Induced Chronic Kidney Disease via Regulating Tryptophan Metabolism and Aryl Hydrocarbon Receptor Signaling , 2022, Frontiers in Pharmacology.

[17]  Mingyuan Han,et al.  Qing`e Pill Inhibits Osteoblast Ferroptosis via ATM Serine/Threonine Kinase (ATM) and the PI3K/AKT Pathway in Primary Osteoporosis , 2022, Frontiers in Pharmacology.

[18]  Guang Chen,et al.  Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis , 2022, Computational and mathematical methods in medicine.

[19]  Chao Huang,et al.  Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment , 2022, Frontiers in Pharmacology.

[20]  W. Pan,et al.  Mechanism of the Curative Effect of Wen-Shen-Jian-Pi Prescription in the Treatment of Amyotrophic Lateral Sclerosis , 2022, Frontiers in Aging Neuroscience.

[21]  V. Bohr,et al.  Neurogenesis in aging and age-related neurodegenerative diseases , 2022, Ageing Research Reviews.

[22]  Haiyang Yu,et al.  Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting immunostimulatory tumor microenvironment , 2022, Journal of Hematology & Oncology.

[23]  Chi-Yuan Chen,et al.  The flavonoid corylin exhibits lifespan extension properties in mouse , 2022, Nature Communications.

[24]  Qianqian Huang,et al.  Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway , 2022, Frontiers in Pharmacology.

[25]  F. d’Adda di Fagagna,et al.  Telomere dysfunction in ageing and age-related diseases , 2022, Nature Cell Biology.

[26]  W. Kuo,et al.  Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[27]  Xiufeng Pang,et al.  YYFZBJS inhibits colorectal tumorigenesis by enhancing Tregs-induced immunosuppression through HIF-1α mediated hypoxia in vivo and in vitro. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[28]  Jiandong Lu,et al.  Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects , 2021, Bioscience reports.

[29]  Xiao M Qin,et al.  Qing-Xue-Xiao-Zhi formula attenuates atherosclerosis by inhibiting macrophage lipid accumulation and inflammatory response via TLR4/MyD88/NF-κB pathway regulation. , 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[30]  Haixia Huang,et al.  Berberine is an insulin secretagogue targeting the KCNH6 potassium channel , 2021, Nature Communications.

[31]  Xi-Long Zheng,et al.  Antiatherosclerotic effect of dehydrocorydaline on ApoE−/− mice: inhibition of macrophage inflammation , 2021, Acta Pharmacologica Sinica.

[32]  A. Orekhov,et al.  BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice. , 2021, Journal of ethnopharmacology.

[33]  Jia-xiu Zhou,et al.  Oxymatrine attenuates oxidized low-density lipoprotein-induced HUVEC injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway , 2021, International journal of molecular medicine.

[34]  Jia-Yu Ke,et al.  The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation , 2021, Drug design, development and therapy.

[35]  Jiayi Hu,et al.  Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins , 2021, Frontiers in Pharmacology.

[36]  Zhen Yang,et al.  Duzhong Fang Attenuates the POMC-Derived Neuroinflammation in Parkinsonian Mice , 2021, Journal of inflammation research.

[37]  Richard T. Lee,et al.  Senescence mechanisms and targets in the heart. , 2021, Cardiovascular research.

[38]  Xingxing Li,et al.  Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome , 2021, NPJ biofilms and microbiomes.

[39]  B. Houot,et al.  G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model , 2021, Aging and disease.

[40]  Jian Li,et al.  Cardiac Aging: From Basic Research to Therapeutics , 2021, Oxidative medicine and cellular longevity.

[41]  Anonymous,et al.  2021 Alzheimer's disease facts and figures , 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[42]  A. Matsuura,et al.  Ehretiquinone from Onosma bracteatum Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction , 2021, Oxidative medicine and cellular longevity.

[43]  T. Farkhondeh,et al.  The role of curcumin in aging and senescence: Molecular mechanisms. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[44]  Y. Diao Clematichinenoside AR Alleviates Foam Cell Formation and the Inflammatory Response in Ox-LDL-Induced RAW264.7 Cells by Activating Autophagy , 2020, Inflammation.

[45]  M. L. Bringas-Vega,et al.  Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity , 2020, Frontiers in Endocrinology.

[46]  Xinrong Li,et al.  [Effect and mechanism of moxibustion on oxidative stress injury in rats with Parkinson's disease by activating Nrf2/ARE pathway]. , 2020, Zhongguo zhen jiu = Chinese acupuncture & moxibustion.

[47]  G. Ortiz,et al.  Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson's disease. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[48]  Lin Zhu,et al.  Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases , 2020, Oxidative medicine and cellular longevity.

[49]  Hua Wang,et al.  Tanshinone IIA prevents platelet activation and down-regulates CD36 and MKK4/JNK2 signaling pathway , 2020, BMC Cardiovascular Disorders.

[50]  Xuehua Jiang,et al.  Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2 , 2020, Liver international : official journal of the International Association for the Study of the Liver.

[51]  R. Patani,et al.  Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective , 2019, Brain : a journal of neurology.

[52]  A. Weeraratna,et al.  How the ageing microenvironment influences tumour progression , 2019, Nature Reviews Cancer.

[53]  D. Fan,et al.  Global variation in prevalence and incidence of amyotrophic lateral sclerosis: a systematic review and meta-analysis , 2019, Journal of Neurology.

[54]  M. Holland,et al.  DNA methylation at the crossroads of gene and environment interactions , 2019, Essays in biochemistry.

[55]  Piao Shenghua,et al.  An integrated fecal microbiome and metabolome in the aged mice reveal anti-aging effects from the intestines and biochemical mechanism of FuFang zhenshu TiaoZhi(FTZ). , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[56]  Qiang Xu,et al.  Andrographolide alleviates Parkinsonism in MPTP‐PD mice via targeting mitochondrial fission mediated by dynamin‐related protein 1 , 2019, British journal of pharmacology.

[57]  Zhenhai Zhang,et al.  Baicalein and baicalin promote antitumor immunity by suppressing PD-L1 expression in hepatocellular carcinoma cells. , 2019, International immunopharmacology.

[58]  U. Smith,et al.  Cellular senescence: at the nexus between ageing and diabetes , 2019, Diabetologia.

[59]  Moshi Song,et al.  Mitochondrial regulation of cardiac aging. , 2019, Biochimica et biophysica acta. Molecular basis of disease.

[60]  Xiaohua Lv,et al.  Allicin alleviates lead-induced hematopoietic stem cell aging by up-regulating PKM2 , 2019, Bioscience reports.

[61]  N. López-Díazguerrero,et al.  Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging , 2019, Biogerontology.

[62]  Houkai Li,et al.  Metabolomics and its application in the treatment of coronary heart disease with traditional Chinese medicine. , 2019, Chinese journal of natural medicines.

[63]  J. Mann,et al.  Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease , 2019, Neuropsychopharmacology.

[64]  Jinyu Li,et al.  Astragaloside IV Protects Against Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Endothelial Cell Injury by Reducing Oxidative Stress and Inflammation , 2019, Medical science monitor : international medical journal of experimental and clinical research.

[65]  Vu Thi Cuong,et al.  The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans , 2019, Experimental Gerontology.

[66]  N. Lu,et al.  Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer , 2018, Journal of Experimental & Clinical Cancer Research.

[67]  Lianfeng Zhang,et al.  Rehmannia glutinosa exhibits anti‐aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells , 2018, Animal models and experimental medicine.

[68]  D. Rubinsztein,et al.  Autophagy as a promoter of longevity: insights from model organisms , 2018, Nature Reviews Molecular Cell Biology.

[69]  P. Zhao,et al.  Restoring Th17/Treg balance via modulation of STAT3 and STAT5 activation contributes to the amelioration of chronic obstructive pulmonary disease by Bufei Yishen formula. , 2018, Journal of ethnopharmacology.

[70]  Jinghui Sun,et al.  Metabolomics study of the therapeutic mechanism of Schisandra chinensis lignans on aging rats induced by d-galactose , 2018, Clinical interventions in aging.

[71]  Jian Zhang,et al.  Effects of Qijian mixture on type 2 diabetes assessed by metabonomics, gut microbiota and network pharmacology , 2018, Pharmacological research.

[72]  D. Odom,et al.  Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species , 2018, Genome Biology.

[73]  H. Cai,et al.  Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1G93A mouse model of amyotrophic lateral sclerosis , 2018, Scientific Reports.

[74]  H. Yoon,et al.  Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury , 2018, Aging.

[75]  J. Hardy,et al.  Alzheimer's disease , 2018, European journal of neurology.

[76]  Xuemei Zhang,et al.  Ethanol extract of Schisandrae chinensis fructus ameliorates the extent of experimentally induced atherosclerosis in rats by increasing antioxidant capacity and improving endothelial dysfunction , 2018, Pharmaceutical biology.

[77]  X. Ren,et al.  Ginsenoside Rg3 attenuates cisplatin resistance in lung cancer by downregulating PD-L1 and resuming immune. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[78]  Chuanshan Xu,et al.  The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation , 2017, Aging and disease.

[79]  Haiping Zhao,et al.  Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic , 2017, Aging and disease.

[80]  T. Efferth Cancer combination therapies with artemisinin‐type drugs , 2017, Biochemical pharmacology.

[81]  X. Lai,et al.  Effect of Dendrobium officinale on D-galactose-induced aging mice , 2017, Chinese journal of integrative medicine.

[82]  Laura Fratiglioni,et al.  Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[83]  C. Harley,et al.  A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study , 2016, Rejuvenation research.

[84]  M. Bennett,et al.  Vascular Smooth Muscle Cells in Atherosclerosis. , 2016, Circulation research.

[85]  M. Jensen,et al.  JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age , 2015, Proceedings of the National Academy of Sciences.

[86]  Lin-lin Zhang,et al.  Cognitive Improvement during Treatment for Mild Alzheimer’s Disease with a Chinese Herbal Formula: A Randomized Controlled Trial , 2015, PloS one.

[87]  Qian Yang,et al.  Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1 , 2015, Neurobiology of Aging.

[88]  Min-Ju Kim,et al.  Inhibition of Mitochondrial Clearance and Cu/Zn-SOD Activity Enhance 6-Hydroxydopamine-Induced Neuronal Apoptosis , 2015, Molecular Neurobiology.

[89]  Hsin-Hung Lin,et al.  Antioxidant effects of 14 Chinese traditional medicinal herbs against human low-density lipoprotein oxidation , 2014, Journal of traditional and complementary medicine.

[90]  Xinyi Mu,et al.  Ginsenoside Rg1 Prevents Cognitive Impairment and Hippocampus Senescence in a Rat Model of D-Galactose-Induced Aging , 2014, PloS one.

[91]  J. Deursen The role of senescent cells in ageing , 2014, Nature.

[92]  Lianyu Chen,et al.  Chinese Herbal Medicine Suppresses Invasion-Promoting Capacity of Cancer-Associated Fibroblasts in Pancreatic Cancer , 2014, PloS one.

[93]  P. Madan,et al.  The p66Shc Adaptor Protein Controls Oxidative Stress Response in Early Bovine Embryos , 2014, PloS one.

[94]  G. Shadel,et al.  Epigenetic silencing mediates mitochondria stress-induced longevity. , 2013, Cell metabolism.

[95]  J. Kushner The role of aging upon β cell turnover. , 2013, The Journal of clinical investigation.

[96]  J. Moss,et al.  LOX-1 in atherosclerosis: biological functions and pharmacological modifiers , 2012, Cellular and Molecular Life Sciences.

[97]  David A Sinclair,et al.  The intersection between aging and cardiovascular disease. , 2012, Circulation research.

[98]  G. Vilahur,et al.  Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease , 2012, European heart journal. Acute cardiovascular care.

[99]  Howard Y. Chang,et al.  Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock , 2012, Cell.

[100]  D. Armant,et al.  Epigenetics: Definition, Mechanisms and Clinical Perspective , 2009, Seminars in reproductive medicine.

[101]  Eran Segal,et al.  Motif module map reveals enforcement of aging by continual NF-κB activity , 2007 .

[102]  Hyun-Joung Lim,et al.  Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model. , 2006, Atherosclerosis.

[103]  H. Lei,et al.  Anti-aging effect of astragalosides and its mechanism of action. , 2003, Acta pharmacologica Sinica.

[104]  M. Ala-Korpela,et al.  Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima , 2000, Journal of internal medicine.

[105]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[106]  K. Seppi,et al.  Parkinson disease , 2017, Nature Reviews Disease Primers.

[107]  E. Noiri,et al.  Nitric Oxide and Endothelial Dysfunction , 2014 .

[108]  Zebo Huang,et al.  Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. , 2012, The Biochemical journal.

[109]  Eran Segal,et al.  Motif module map reveals enforcement of aging by continual NF-kappaB activity. , 2007, Genes & development.