Particle and Fibre Toxicology Iron Oxide Nanoparticles Induce Human Microvascular Endothelial Cell Permeability through Reactive Oxygen Species Production and Microtubule Remodeling

Background: Engineered iron nanoparticles are being explored for the development of biomedical applications and many other industry purposes. However, to date little is known concerning the precise mechanisms of translocation of iron nanoparticles into targeted tissues and organs from blood circulation, as well as the underlying implications of potential harmful health effects in human.

[1]  Saber M Hussain,et al.  Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[2]  G. Hu,et al.  Regulation of endothelial permeability by Src kinase signaling: vascular leakage versus transcellular transport of drugs and macromolecules. , 2008, Chemico-biological interactions.

[3]  K. Shankar,et al.  Protective Effects of Estradiol on Ethanol-Induced Bone Loss Involve Inhibition of Reactive Oxygen Species Generation in Osteoblasts and Downstream Activation of the Extracellular Signal-Regulated Kinase/Signal Transducer and Activator of Transcription 3/Receptor Activator of Nuclear Factor-κB Ligan , 2008, Journal of Pharmacology and Experimental Therapeutics.

[4]  P. Salinas.  Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway. , 2007, Trends in cell biology.

[5]  Sungho Jin,et al.  Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. , 2007, Biomaterials.

[6]  A. Shimada,et al.  Translocation Pathway of the Intratracheally Instilled Ultrafine Particles from the Lung into the Blood Circulation in the Mouse , 2006, Toxicologic pathology.

[7]  Philippe Robert,et al.  Recent advances in iron oxide nanocrystal technology for medical imaging. , 2006, Advanced drug delivery reviews.

[8]  Maureen R. Gwinn,et al.  Nanoparticles: Health Effects—Pros and Cons , 2006, Environmental health perspectives.

[9]  J. Huot,et al.  Dysregulation of the endothelial cellular response to oxidative stress in cancer , 2006, Molecular carcinogenesis.

[10]  Silvia Muro,et al.  Advanced drug delivery systems that target the vascular endothelium. , 2006, Molecular interventions.

[11]  A. Ivanov,et al.  Microtubules regulate disassembly of epithelial apical junctions , 2006, BMC Cell Biology.

[12]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[13]  P. Baron,et al.  Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[14]  Feng Liu,et al.  MAP kinases in lung endothelial permeability induced by microtubule disassembly. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[15]  D. Huber,et al.  Synthesis, properties, and applications of iron nanoparticles. , 2005, Small.

[16]  A. C. Hunter,et al.  Nanomedicine: current status and future prospects , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  Xianglin Shi,et al.  Cdc42 Regulates Arsenic-induced NADPH Oxidase Activation and Cell Migration through Actin Filament Reorganization* , 2005, Journal of Biological Chemistry.

[18]  F. Liu,et al.  Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: Role of Rho‐dependent mechanisms , 2004, Journal of cellular physiology.

[19]  Bruno Brochet,et al.  Macrophage Imaging in Central Nervous System and in Carotid Atherosclerotic Plaque Using Ultrasmall Superparamagnetic Iron Oxide in Magnetic Resonance Imaging , 2004, Investigative radiology.

[20]  R. Shao,et al.  Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis. , 2004, Biochemical and biophysical research communications.

[21]  Atle Bjørnerud,et al.  Hepatic cellular distribution and degradation of iron oxide nanoparticles following single intravenous injection in rats: implications for magnetic resonance imaging , 2004, Cell and Tissue Research.

[22]  Isabelle Raynal,et al.  Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles: Mechanisms and Comparison of Ferumoxides and Ferumoxtran-10 , 2004, Investigative radiology.

[23]  L. Munn,et al.  Aberrant vascular architecture in tumors and its importance in drug-based therapies. , 2003, Drug discovery today.

[24]  S. Yuan.  Protein kinase signaling in the modulation of microvascular permeability. , 2002, Vascular pharmacology.

[25]  V. Labhasetwar,et al.  Characterization of nanoparticle uptake by endothelial cells. , 2002, International journal of pharmaceutics.

[26]  H. Lum,et al.  Oxidant stress and endothelial cell dysfunction. , 2001, American journal of physiology. Cell physiology.

[27]  A. Hyman,et al.  Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation , 2001, Current Biology.

[28]  D. Flynn,et al.  Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity , 1998, Oncogene.

[29]  G. Hunninghake,et al.  Reversible oxidant-induced increases in albumin transfer across cultured endothelium: alterations in cell shape and calcium homeostasis. , 1985, Blood.

[30]  B. Ames,et al.  Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. , 1983, Analytical biochemistry.

[31]  A. Malik,et al.  Signaling mechanisms regulating endothelial permeability. , 2006, Physiological reviews.

[32]  J. Garcia,et al.  The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. , 2003, American journal of respiratory cell and molecular biology.

[33]  F. Curry,et al.  Microvascular permeability. , 1999, Physiological reviews.

[34]  R. Maier,et al.  Oxidant-induced endothelial leak correlates with decreased cellular energy levels. , 1990, The American review of respiratory disease.