Cytomorphologic features of intraductal salivary gland carcinoma: A multi‐institutional study of 13 FNA cases with histologic, molecular, and clinical correlations

Intraductal carcinoma of the salivary gland (IDC) is a rare cancer with potential actionable targets, including RET fusions. Histologic and molecular features of IDC were recently reported, but cytomorphologic data are limited. In the largest multi‐institutional fine‐needle aspiration (FNA) series, the authors describe the cytomorphologic features of 13 IDC cases with available clinical, radiologic, histopathologic, and molecular data.

[1]  D. Dias-Santagata,et al.  Intraductal Carcinoma of the Salivary Gland with NCOA4-RET: Expanding the Morphologic Spectrum and an Algorithmic Diagnostic Approach. , 2021, Human pathology.

[2]  E. Rodriguez,et al.  Therapeutic strategies in RET gene rearranged non-small cell lung cancer , 2021, Journal of Hematology & Oncology.

[3]  I. Weinreb,et al.  Intraductal Carcinomas of the Salivary Gland. , 2021, Surgical pathology clinics.

[4]  J. Bishop,et al.  Oncocytic intraductal carcinoma of salivary glands: a distinct variant with TRIM33–RET fusions and BRAF V600E mutations , 2020, Histopathology.

[5]  A. Sangoi,et al.  The Myoepithelial Cells of Salivary Intercalated Duct-type Intraductal Carcinoma Are Neoplastic: A Study Using Combined Whole-slide Imaging, Immunofluorescence, and RET Fluorescence In Situ Hybridization. , 2020, The American journal of surgical pathology.

[6]  W. Faquin,et al.  Cytomorphologic features of NTRK‐rearranged thyroid carcinoma , 2020, Cancer cytopathology.

[7]  A. Franchi,et al.  MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics , 2020, Histopathology.

[8]  D. Dias-Santagata,et al.  Clinicopathologic Features of Kinase Fusion-related Thyroid Carcinomas: An Integrative Analysis with Molecular Characterization , 2020, Modern Pathology.

[9]  J. Bishop,et al.  Salivary Intraductal Carcinoma Arising within Intraparotid Lymph Node: A Report of 4 Cases with Identification of a Novel STRN-ALK Fusion , 2020, Head and Neck Pathology.

[10]  B. Vicandi,et al.  Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature , 2020, Diagnostic cytopathology.

[11]  T. Nagao,et al.  Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment , 2020, Cancer cytopathology.

[12]  J. Bishop,et al.  Low-grade Apocrine Intraductal Carcinoma: Expanding the Morphologic and Molecular Spectrum of an Enigmatic Salivary Gland Tumor , 2020, Head and Neck Pathology.

[13]  A. Palicelli.  What do we know about the cytological features of pure intraductal carcinomas of the salivary glands? , 2019, Cytopathology : official journal of the British Society for Clinical Cytology.

[14]  V. Adamo,et al.  RET fusions in solid tumors. , 2019, Cancer treatment reviews.

[15]  F. Giovacchini,et al.  Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity. , 2019, Journal of oral biology and craniofacial research.

[16]  J. Bishop,et al.  Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions: A Report of 17 cases , 2018, The American journal of surgical pathology.

[17]  T. Nagao,et al.  Low‐grade intraductal carcinoma of the salivary gland with prominent oncocytic change: a newly described variant , 2018, Histopathology.

[18]  A. Drilon,et al.  Selective RET kinase inhibition for patients with RET-altered cancers , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

[19]  Christopher C. Griffith,et al.  Ancillary testing strategies in salivary gland aspiration cytology: A practical pattern‐based approach , 2017, Diagnostic cytopathology.

[20]  T. Nakano,et al.  Low-grade intraductal carcinoma (low-grade cribriform cystadenocarcinoma) with tumor-associated lymphoid proliferation of parotid gland. , 2017, Pathology, research and practice.

[21]  P. Stephens,et al.  Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations , 2016, Clinical Cancer Research.

[22]  H. Fujisaki,et al.  Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers , 2015, Cancer cytopathology.

[23]  Simion I. Chiosea,et al.  The cytological features of mammary analogue secretory carcinoma , 2013, Cancer cytopathology.

[24]  J. Bishop,et al.  GATA3 Immunohistochemical Expression in Salivary Gland Neoplasms , 2013, Head and Neck Pathology.

[25]  T. H. van der Kwast,et al.  Low-grade Intraductal Carcinoma of Salivary Gland: Report of 3 Cases With Marked Apocrine Differentiation , 2006, The American journal of surgical pathology.

[26]  K. T. Chen.  Intraductal carcinoma of the minor salivary gland , 1983, The Journal of Laryngology & Otology.

[27]  N. Katabi,et al.  The Milan System for Reporting Salivary Gland Cytopathology , 2018, Springer International Publishing.

[28]  K. Riden,et al.  CLASSIFICATION OF HEAD AND NECK TUMOURS , 1998 .