Guidelines for reasonable and appropriate care in the emergency department 3 (GRACE‐3): Acute dizziness and vertigo in the emergency department

This third Guideline for Reasonable and Appropriate Care in the Emergency Department (GRACE‐3) from the Society for Academic Emergency Medicine is on the topic adult patients with acute dizziness and vertigo in the emergency department (ED). A multidisciplinary guideline panel applied the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and strength of recommendations regarding five questions for adult ED patients with acute dizziness of less than 2 weeks' duration. The intended population is adults presenting to the ED with acute dizziness or vertigo. The panel derived 15 evidence‐based recommendations based on the timing and triggers of the dizziness but recognizes that alternative diagnostic approaches exist, such as the STANDING protocol and nystagmus examination in combination with gait unsteadiness or the presence of vascular risk factors. As an overarching recommendation, (1) emergency clinicians should receive training in bedside physical examination techniques for patients with the acute vestibular syndrome (AVS; HINTS) and the diagnostic and therapeutic maneuvers for benign paroxysmal positional vertigo (BPPV; Dix–Hallpike test and Epley maneuver). To help distinguish central from peripheral causes in patients with the AVS, we recommend: (2) use HINTS (for clinicians trained in its use) in patients with nystagmus, (3) use finger rub to further aid in excluding stroke in patients with nystagmus, (4) use severity of gait unsteadiness in patients without nystagmus, (5) do not use brain computed tomography (CT), (6) do not use routine magnetic resonance imaging (MRI) as a first‐line test if a clinician trained in HINTS is available, and (7) use MRI as a confirmatory test in patients with central or equivocal HINTS examinations. In patients with the spontaneous episodic vestibular syndrome: (8) search for symptoms or signs of cerebral ischemia, (9) do not use CT, and (10) use CT angiography or MRI angiography if there is concern for transient ischemic attack. In patients with the triggered (positional) episodic vestibular syndrome, (11) use the Dix–Hallpike test to diagnose posterior canal BPPV (pc‐BPPV), (12) do not use CT, and (13) do not use MRI routinely, unless atypical clinical features are present. In patients diagnosed with vestibular neuritis, (14) consider short‐term steroids as a treatment option. In patients diagnosed with pc‐BPPV, (15) treat with the Epley maneuver. It is clear that as of 2023, when applied in routine practice by emergency clinicians without special training, HINTS testing is inaccurate, partly due to use in the wrong patients and partly due to issues with its interpretation. Most emergency physicians have not received training in use of HINTS. As such, it is not standard of care, either in the legal sense of that term (“what the average physician would do in similar circumstances”) or in the common parlance sense (“the standard action typically used by physicians in routine practice”).

[1]  O. Ganansia,et al.  Effectiveness and reliability of the four‐step STANDING algorithm performed by interns and senior emergency physicians for predicting central causes of vertigo , 2023, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[2]  M. Farah,et al.  Diagnostic accuracy of the physical examination in emergency department patients with acute vertigo or dizziness: A systematic review and meta‐analysis for GRACE‐3 , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[3]  S. Vanni,et al.  Timing for nystagmus evaluation by STANDING or HINTS in patients with vertigo/dizziness in the emergency department , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[4]  J. Edlow,et al.  Dizziness as a missed symptom of central nervous system pathology: A review of malpractice cases , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[5]  C. Carpenter,et al.  Nothing about me without me: GRACE‐fully partnering with patients to derive clinical practice guidelines , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[6]  J. Edlow,et al.  Vestibular suppressants for benign paroxysmal positional vertigo: A systematic review and meta‐analysis of randomized controlled trials , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[7]  J. Edlow,et al.  Corticosteroids for patients with vestibular neuritis: An evidence synthesis for guidelines for reasonable and appropriate care in the emergency department , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[8]  S. Matsui,et al.  The finger-to-nose test improved diagnosis of cerebrovascular events in patients presenting with isolated dizziness in the emergency department , 2022, Nagoya journal of medical science.

[9]  M. Farah,et al.  Diagnostic accuracy of neuroimaging in emergency department patients with acute vertigo or dizziness: A systematic review and meta‐analysis for the guidelines for reasonable and appropriate care in the emergency department , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[10]  Jonathan M. Kirschner,et al.  Efficacy of Benzodiazepines or Antihistamines for Patients With Acute Vertigo: A Systematic Review and Meta-analysis. , 2022, JAMA neurology.

[11]  J. Edlow Acute dizziness: A personal journey through a paradigm shift , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[12]  J. Edlow,et al.  Benign paroxysmal positional vertigo: A practical approach for emergency physicians , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[13]  M. Caversaccio,et al.  Videooculography “HINTS” in Acute Vestibular Syndrome: A Prospective Study , 2022, Frontiers in Neurology.

[14]  K. Jahn,et al.  Acute unilateral vestibulopathy/vestibular neuritis: Diagnostic criteria , 2022, Journal of vestibular research : equilibrium & orientation.

[15]  M. Repplinger,et al.  Guidelines for Reasonable and Appropriate Care in the Emergency Department 2 (GRACE‐2): Low‐risk, recurrent abdominal pain in the emergency department , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[16]  D. Newman-Toker,et al.  Video-Oculography to Guide Neuroimaging for Dizziness and Vertigo. , 2022, JAMA otolaryngology-- head & neck surgery.

[17]  C. Carpenter,et al.  A candle in the dark: The role of indirect evidence in emergency medicine clinical practice guidelines , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[18]  H. Rambold,et al.  Identification of Stroke and TIA in Patients With Acute Dizziness, Vertigo or Imbalance in Emergency Departments of Primary Care Hospitals: Early Experiences With a Network-Based Telemedical Approach , 2022, Frontiers in Neurology.

[19]  Ying Bi,et al.  A Dynamic Nomogram to Predict the Risk of Stroke in Emergency Department Patients With Acute Dizziness , 2022, Frontiers in Neurology.

[20]  Yu Zhao,et al.  Current Therapies in Patients With Posterior Semicircular Canal BPPV, a Systematic Review and Network Meta-analysis , 2022, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[21]  H. Rambold,et al.  Feasibility of Telemedical HINTS (Head Impulse-Nystagmus-Test of Skew) Evaluation in Patients With Acute Dizziness or Vertigo in the Emergency Department of Primary Care Hospitals , 2022, Frontiers in Neurology.

[22]  J. E. Shin,et al.  Incidence of idiopathic benign paroxysmal positional vertigo subtype by hospital visit type: experience of a single tertiary referral centre , 2021, The Journal of Laryngology & Otology.

[23]  S. Gutnikov,et al.  Long-Term Impact of Urgent Secondary Prevention After Transient Ischemic Attack and Minor Stroke: Ten-Year Follow-Up of the EXPRESS Study , 2021, Stroke.

[24]  J. Olesen,et al.  Vestibular migraine: Diagnostic criteria (Update) , 2021, Journal of vestibular research : equilibrium & orientation.

[25]  Kristal M. Riska,et al.  A Comparison of Falls and Dizziness Handicap by Vestibular Diagnosis. , 2021, American journal of audiology.

[26]  K. Bashir,et al.  Teaching Benign Paroxysmal Positional Vertigo to Emergency Medicine Residents by Using Gagne’s Nine Steps of Instructional Design , 2021, Advances in medical education and practice.

[27]  D. Gladstone,et al.  Predictors of neurologists confirming or overturning emergency physicians' diagnosis of TIA or stroke , 2021, Canadian Journal of Emergency Medicine.

[28]  A. Bradshaw,et al.  Capturing vertigo in the emergency room: three tools to double the rate of diagnosis , 2021, Journal of Neurology.

[29]  Benjamin T. Burdorf Comparing magnetic resonance imaging and computed tomography machine accessibility among urban and rural county hospitals , 2021, Journal of Public Health Research.

[30]  G. Chatellier,et al.  Differentiating central from peripheral causes of acute vertigo in an emergency setting with the HINTS, STANDING, and ABCD2 tests: A diagnostic cohort study , 2021, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[31]  M. Caversaccio,et al.  Acute vestibular syndrome: is skew deviation a central sign? , 2021, Journal of Neurology.

[32]  E. Hess,et al.  Guidelines for reasonable and appropriate care in the emergency department (GRACE): Recurrent, low‐risk chest pain in the emergency department , 2021, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[33]  D. Zee,et al.  Bruns' nystagmus revisited: A sign of stroke in patients with the acute vestibular syndrome , 2021, European journal of neurology.

[34]  Thomas Wellings,et al.  Benign paroxysmal positional vertigo in the emergency department: An observational study of an Australian regional hospital's acute clinical practice , 2021, Emergency medicine Australasia : EMA.

[35]  J. Kline,et al.  Navigating uncertainty with GRACE: Society for Academic Emergency Medicine’s guidelines for reasonable and appropriate care in the emergency department , 2021, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[36]  G. Tan,et al.  Central nystagmus plus ABCD2 identifying stroke in acute dizziness presentations , 2021, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[37]  D. Zee,et al.  Impaired fixation suppression of horizontal vestibular nystagmus during smooth pursuit: pathophysiology and clinical implications , 2021, European journal of neurology.

[38]  J. Choi,et al.  Transient Vestibular Symptoms Preceding Posterior Circulation Stroke , 2021, Stroke.

[39]  A. Luft,et al.  Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial , 2021, The Lancet Neurology.

[40]  Ana Catarina Fonseca,et al.  European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA , 2021, European stroke journal.

[41]  R. Lepage,et al.  The use and misuse of the Dix-Hallpike test in the emergency department , 2021, Canadian Journal of Emergency Medicine.

[42]  P. Rothwell,et al.  Diagnosis of non-consensus transient ischaemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis , 2021, The Lancet.

[43]  Hyun-June Shin,et al.  Clinical Implication of Corrective Saccades in the Video Head Impulse Test for the Diagnosis of Posterior Inferior Cerebellar Artery Infarction , 2021, Frontiers in Neurology.

[44]  D. Gladstone,et al.  Prospective validation of Canadian TIA Score and comparison with ABCD2 and ABCD2i for subsequent stroke risk after transient ischaemic attack: multicentre prospective cohort study , 2021, BMJ.

[45]  E. Canetti,et al.  Systematic Review and Meta-analysis: Effectiveness of Corticosteroids in Treating Adults With Acute Vestibular Neuritis , 2021, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[46]  N. Zakhari,et al.  Limited usefulness of routine head and neck CT angiogram in the imaging assessment of dizziness in the emergency department , 2021, The neuroradiology journal.

[47]  Deepak S. Phalgune,et al.  Diagnosing Stroke in Acute Vertigo: Sensitivity and Specificity of HINTS Battery in Indian Population. , 2021, Neurology India.

[48]  T. Schermer,et al.  Two Symptoms Strongly Suggest Benign Paroxysmal Positional Vertigo in a Dizzy Patient , 2021, Frontiers in Neurology.

[49]  P. Trillenberg,et al.  Usability of the head impulse test in routine clinical practice in the emergency department to differentiate vestibular neuritis from stroke , 2020, European journal of neurology.

[50]  R. Lepage,et al.  Diagnostic Accuracy of the HINTS Exam in an Emergency Department: A Retrospective Chart Review , 2020, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[51]  C. Finizia,et al.  Benign paroxysmal positional vertigo, dizziness, and health-related quality of life among older adults in a population-based setting , 2020, European Archives of Oto-Rhino-Laryngology.

[52]  C. Papanastasiou,et al.  Predictors of vertigo in the emergency department: The preved study. , 2020, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[53]  Turgay Yılmaz Kılıç,et al.  The Incidence of Central Neurological Disorders Among Patients With Isolated Dizziness and the Diagnostic Yield of Neuroimaging Studies , 2020, The neurologist.

[54]  C. Anderson,et al.  Separating posterior-circulation stroke from vestibular neuritis with quantitative vestibular testing , 2020, Clinical Neurophysiology.

[55]  W. Heide,et al.  Risk of acute brain lesions in dizzy patients presenting to the emergency room: who needs imaging and who does not? , 2020, Journal of Neurology.

[56]  R. Ohle,et al.  Can Emergency Physicians Accurately Rule Out a Central Cause of Vertigo Using the HINTS Examination? A Systematic Review and Meta‐analysis , 2020, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[57]  G. Guyatt,et al.  GRADE guidelines: 21 part 1. Study design, risk of bias and indirectness in rating the certainty across a body of evidence for test accuracy. , 2020, Journal of clinical epidemiology.

[58]  G. Guyatt,et al.  GRADE guidelines: 21 part 2. Inconsistency, Imprecision, publication bias and other domains for rating the certainty of evidence for test accuracy and presenting it in evidence profiles and summary of findings tables. , 2020, Journal of clinical epidemiology.

[59]  K. Kerber Acute Vestibular Syndrome , 2020, Seminars in Neurology.

[60]  Benqiang Deng,et al.  Safety and Efficacy of Intravenous Thrombolytic Therapy in Patients With Acute Posterior Circulation Stroke: A Single-Center Study. , 2019, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[61]  J. Edlow The timing-and-triggers approach to the patient with acute dizziness. , 2019, Emergency medicine practice.

[62]  S. Johnston,et al.  Outcomes Associated With Clopidogrel-Aspirin Use in Minor Stroke or Transient Ischemic Attack: A Pooled Analysis of Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events (CHANCE) and Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trials. , 2019, JAMA neurology.

[63]  S. Mossman,et al.  Central mimics of benign paroxysmal positional vertigo: an illustrative case series , 2019, Neurological Sciences.

[64]  S. Telian,et al.  An Educational Intervention for Acute Dizziness Care: A Randomized, Vignette-based Study. , 2019, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[65]  S. Telian,et al.  Implementation of Evidence-Based Practice for Benign Paroxysmal Positional Vertigo in the Emergency Department: A Stepped-Wedge Randomized Trial. , 2019, Annals of emergency medicine.

[66]  Hugh S Markus,et al.  Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results. , 2019, JAMA neurology.

[67]  J. Salzer,et al.  Effectiveness of care in acute dizziness presentations , 2019, European Archives of Oto-Rhino-Laryngology.

[68]  S. Nordahl,et al.  Dizziness handicap and clinical characteristics of posterior and lateral canal BPPV , 2019, European Archives of Oto-Rhino-Laryngology.

[69]  Sion Jo,et al.  Incidence of acute cerebral infarction or space occupying lesion among patients with isolated dizziness and the role of D-dimer , 2019, PloS one.

[70]  Kangzhi Li,et al.  Diagnostic value of eye movement and vestibular function tests in patients with posterior circulation infarction , 2019, Acta oto-laryngologica.

[71]  M. Magnusson,et al.  Steroids for Acute Vestibular Neuronitis—the Earlier the Treatment, the Better the Outcome? , 2019, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[72]  J. Lemos,et al.  Positional Testing in Acute Vestibular Syndrome: a Transversal and Longitudinal Study. , 2019, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[73]  J. Kattah,et al.  Central positional vertigo: A clinical-imaging study. , 2019, Progress in brain research.

[74]  C. Finizia,et al.  Asking about dizziness when turning in bed predicts examination findings for benign paroxysmal positional vertigo. , 2018, Journal of vestibular research : equilibrium & orientation.

[75]  J. Edlow Managing Patients With Acute Episodic Dizziness. , 2018, Annals of emergency medicine.

[76]  C. Carnevale,et al.  Identification of Factors Related to Cases of Benign Paroxysmal Positional Vertigo Refractory to Canalicular Repositioning Maneuvers and Evaluation of the Need for Magnetic Resonance Imaging in their Management: Retrospective Analysis of a Series of 176 Cases , 2018, International Archives of Otorhinolaryngology.

[77]  Tomislav Pavlović,et al.  Value of Head CT Scan in the Emergency Department in Patients with Vertigo without Focal Neurological Abnormalities , 2018, Open access Macedonian journal of medical sciences.

[78]  E. Kwok,et al.  Usage of the HINTS exam and neuroimaging in the assessment of peripheral vertigo in the emergency department , 2018, Journal of Otolaryngology - Head & Neck Surgery.

[79]  Hyeonseok Cho,et al.  Antihistamine use and the risk of injurious falls or fracture in elderly patients: a systematic review and meta-analysis , 2018, Osteoporosis International.

[80]  G. Tedeschi,et al.  Clinical Features, Familial History, and Migraine Precursors in Patients With Definite Vestibular Migraine: The VM‐Phenotypes Projects , 2018, Headache.

[81]  D. Newman-Toker,et al.  A New Diagnostic Approach to the Adult Patient with Acute Dizziness. , 2018, The Journal of emergency medicine.

[82]  S. Vanni,et al.  Duplex Sonography of Vertebral Arteries for Evaluation of Patients with Acute Vertigo. , 2017, Ultrasound in medicine & biology.

[83]  J. Edlow Diagnosing Patients With Acute-Onset Persistent Dizziness. , 2017, Annals of emergency medicine.

[84]  R. Walsh,et al.  Our experience with 500 patients with benign paroxysmal positional vertigo: Reexploring aetiology and reevaluating MRI investigation. , 2017, Auris, nasus, larynx.

[85]  J. Edlow Managing Patients With Transient Ischemic Attack. , 2017, Annals of emergency medicine.

[86]  G. Guyatt,et al.  [GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines]. , 2018, Gaceta sanitaria.

[87]  E. Newton Addressing overuse in emergency medicine: evidence of a role for greater patient engagement , 2017, Clinical and experimental emergency medicine.

[88]  S. Telian,et al.  Dizziness Symptom Type Prevalence and Overlap: A US Nationally Representative Survey. , 2017, The American journal of medicine.

[89]  J. Salzer,et al.  Dizziness and the Acute Vestibular Syndrome at the Emergency Department: A Population-Based Descriptive Study , 2017, European Neurology.

[90]  S. Vanni,et al.  Differential Diagnosis of Vertigo in the Emergency Department: A Prospective Validation Study of the STANDING Algorithm , 2017, Front. Neurol..

[91]  E. Hess,et al.  Patient centred diagnosis: sharing diagnostic decisions with patients in clinical practice , 2017, British Medical Journal.

[92]  C. Kase,et al.  Cerebellar stroke presenting with isolated dizziness: Brain MRI in 136 patients , 2017, The American journal of emergency medicine.

[93]  J. Powell,et al.  Benign Paroxysmal Positional Vertigo: Management and Its Impact on Falls , 2017, The Annals of otology, rhinology, and laryngology.

[94]  B. Edlow,et al.  Diagnosis of DWI-negative acute ischemic stroke , 2017, Neurology.

[95]  C. Nunes,et al.  Neurosonology Accuracy for Isolated Acute Vestibular Syndromes , 2017, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[96]  T. Blasberg,et al.  Isolated transient vertigo: posterior circulation ischemia or benign origin? , 2017, BMC Neurology.

[97]  S. Telian,et al.  Barriers and facilitators to ED physician use of the test and treatment for BPPV , 2017, Neurology. Clinical practice.

[98]  H. El-Kashlan,et al.  Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update) , 2017, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[99]  W. Zohdy,et al.  Dizziness in a community hospital: central neurological causes, clinical predictors, and diagnostic yield and cost of neuroimaging studies , 2017, Journal of community hospital internal medicine perspectives.

[100]  Ji-Soo Kim,et al.  Acute Transient Vestibular Syndrome: Prevalence of Stroke and Efficacy of Bedside Evaluation , 2017, Stroke.

[101]  P. Akyol,et al.  Evaluation of the CCT and MRI results of patients hospitalized after applying to the emergency department with vertigo complaints , 2017 .

[102]  H. Schünemann,et al.  [GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 1: Introduction.] , 2017, Recenti progressi in medicina.

[103]  B. Seemungal,et al.  Age-Related Vestibular Loss: Current Understanding and Future Research Directions , 2016, Front. Neurol..

[104]  G. Guyatt,et al.  Guideline panels should seldom make good practice statements: guidance from the GRADE Working Group. , 2016, Journal of clinical epidemiology.

[105]  M Wintermark,et al.  Utilizing dual energy CT to improve CT diagnosis of posterior fossa ischemia. , 2016, Journal of neuroradiology. Journal de neuroradiologie.

[106]  A. Schneider,et al.  Keep it simple: vascular risk factors and focal exam findings correctly identify posterior circulation ischemia in “dizzy” patients , 2016, BMC Emergency Medicine.

[107]  C. Gordon,et al.  The Diagnostic Accuracy of Truncal Ataxia and HINTS as Cardinal Signs for Acute Vestibular Syndrome , 2016, Front. Neurol..

[108]  Elie A Akl,et al.  GRADE Guidelines: 16. GRADE evidence to decision frameworks for tests in clinical practice and public health. , 2016, Journal of clinical epidemiology.

[109]  N. Thomas,et al.  Assessment for benign paroxysmal positional vertigo in medical patients admitted with falls in a district general hospital. , 2016, Clinical medicine.

[110]  D. Fatovich The inverted U curve and emergency medicine: Overdiagnosis and the law of unintended consequences , 2016, Emergency medicine Australasia : EMA.

[111]  G. Guyatt,et al.  GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines , 2016, British Medical Journal.

[112]  Gordon H Guyatt,et al.  GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 1: Introduction , 2016, British Medical Journal.

[113]  D. Newman-Toker,et al.  Using the Physical Examination to Diagnose Patients with Acute Dizziness and Vertigo. , 2016, The Journal of emergency medicine.

[114]  T. McDowell,et al.  The Under-Utilization of the Head Impulse Test in the Emergency Department , 2016, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[115]  D. Newman-Toker Missed stroke in acute vertigo and dizziness: It is time for action, not debate , 2016, Annals of neurology.

[116]  P. Austin,et al.  Outcomes among patients discharged from the emergency department with a diagnosis of peripheral vertigo , 2016, Annals of neurology.

[117]  B. Kane,et al.  Cognition and Decision Making , 2016 .

[118]  J. Kline,et al.  Clinical Decision Rules for Diagnostic Imaging in the Emergency Department: A Research Agenda. , 2015, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[119]  Eric E. Adelman,et al.  Stroke risk stratification in acute dizziness presentations , 2015, Neurology.

[120]  M. Strupp,et al.  Diagnostic criteria for Menière's disease. , 2015, Journal of vestibular research : equilibrium & orientation.

[121]  D. Ballard,et al.  Emergency Physician Attitudes, Preferences, and Risk Tolerance for Stroke as a Potential Cause of Dizziness Symptoms , 2015, The western journal of emergency medicine.

[122]  D. Newman-Toker,et al.  Misdiagnosing Dizzy Patients: Common Pitfalls in Clinical Practice. , 2015, Neurologic clinics.

[123]  D. Newman-Toker,et al.  Medical and Nonstroke Neurologic Causes of Acute, Continuous Vestibular Symptoms. , 2015, Neurologic clinics.

[124]  M. Strupp,et al.  Acute Unilateral Vestibulopathy. , 2015, Neurologic clinics.

[125]  P. Cameron,et al.  Continuing lack of the diagnosis of benign paroxysmal positional vertigo in a tertiary care emergency department , 2015, Emergency medicine Australasia : EMA.

[126]  D. Newman-Toker,et al.  Overview of the International Classification of Vestibular Disorders. , 2015, Neurologic clinics.

[127]  S. Connor,et al.  Diagnostic yield and impact of MRI for acute ischaemic stroke in patients presenting with dizziness and vertigo. , 2015, Clinical radiology.

[128]  G. Guyatt,et al.  Guideline panels should not GRADE good practice statements. , 2015, Journal of clinical epidemiology.

[129]  C. Kao,et al.  Benign paroxysmal positional vertigo is associated with an increased risk of fracture: a population-based cohort study. , 2015, The Journal of orthopaedic and sports physical therapy.

[130]  J. S. Kim,et al.  Vertigo and nystagmus in orthostatic hypotension , 2015, European journal of neurology.

[131]  S. Vanni,et al.  Can emergency physicians accurately and reliably assess acute vertigo in the emergency department? , 2015, Emergency medicine Australasia : EMA.

[132]  S. Mcguigan,et al.  Importance of spontaneous nystagmus detection in the differential diagnosis of acute vertigo , 2015, Journal of Clinical Neuroscience.

[133]  F. Gao,et al.  The ABCD2 score is better for stroke risk prediction after anterior circulation TIA compared to posterior circulation TIA , 2015, The International journal of neuroscience.

[134]  P. Austin,et al.  Missed Strokes Using Computed Tomography Imaging in Patients With Vertigo: Population-Based Cohort Study , 2015, Stroke.

[135]  Stephanie Oberfoell Stroke Risk after Nonstroke Emergency Department Dizziness Presentations: A Population-based Cohort Study , 2015 .

[136]  T. Brandt,et al.  Benign paroxysmal positional vertigo: Diagnostic criteria. , 2015, Journal of vestibular research : equilibrium & orientation.

[137]  J. Hoffman,et al.  Intolerance of error and culture of blame drive medical excess , 2014, BMJ : British Medical Journal.

[138]  Ji-Soo Kim,et al.  Isolated vestibular syndrome in posterior circulation stroke: Frequency and involved structures , 2014, Neurology. Clinical practice.

[139]  M. Strupp,et al.  The takeaway Frenzel goggles , 2014, Neurology.

[140]  A. Fendrick,et al.  Stroke risk after nonstroke emergency department dizziness presentations , 2014, Annals of neurology.

[141]  W. Grolman,et al.  Rapid Systematic Review of Repeated Application of the Epley Maneuver for Treating Posterior BPPV , 2014, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[142]  Max Wintermark,et al.  Recommendations for the Management of Cerebral and Cerebellar Infarction With Swelling: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2014, Stroke.

[143]  D. Zee,et al.  Clinical practice. Benign paroxysmal positional vertigo. , 2014, The New England journal of medicine.

[144]  T. Bruintjes,et al.  Systematic Review , 2014, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[145]  J. Edlow,et al.  A prospective pilot study of predictors of acute stroke in emergency department patients with dizziness. , 2014, Mayo Clinic proceedings.

[146]  S. Nishiike,et al.  Differential diagnosis of vertigo and dizziness in the emergency department , 2014, Acta oto-laryngologica.

[147]  Á. Batuecas-Caletrío,et al.  [Peripheral vertigo versus central vertigo. Application of the HINTS protocol]. , 2014, Revista de neurologia.

[148]  H. Jung,et al.  The Usefulness of Magnetic Resonance Imaging for Acute Isolated Vertigo Patients in the Emergency , 2014 .

[149]  Christopher R Carpenter,et al.  Understanding the direction of bias in studies of diagnostic test accuracy. , 2013, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[150]  P. Rothwell,et al.  Posterior circulation ischaemic stroke and transient ischaemic attack: diagnosis, investigation, and secondary prevention , 2013, The Lancet Neurology.

[151]  D. Zee,et al.  HINTS outperforms ABCD2 to screen for stroke in acute continuous vertigo and dizziness. , 2013, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[152]  J. Edlow Diagnosing dizziness: we are teaching the wrong paradigm! , 2013, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[153]  M. Seidman,et al.  The costs and utility of imaging in evaluating dizzy patients in the emergency room , 2013, The Laryngoscope.

[154]  D. Newman-Toker,et al.  Rising annual costs of dizziness presentations to U.S. emergency departments. , 2013, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[155]  David Rind,et al.  GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength. , 2013, Journal of clinical epidemiology.

[156]  Elie A Akl,et al.  GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. , 2013, Journal of clinical epidemiology.

[157]  G. D. De Marchis,et al.  Differences and Similarities Between Spontaneous Dissections of the Internal Carotid Artery and the Vertebral Artery , 2013, Stroke.

[158]  B. Branstetter,et al.  Yield of CT Angiography and Contrast-Enhanced MR Imaging in Patients with Dizziness , 2013, American Journal of Neuroradiology.

[159]  Georgios Mantokoudis,et al.  Quantitative Video-Oculography to Help Diagnose Stroke in Acute Vertigo and Dizziness: Toward an ECG for the Eyes , 2013, Stroke.

[160]  P. Rothwell,et al.  Stroke Risk After Posterior Circulation Stroke/Transient Ischemic Attack and its Relationship to Site of Vertebrobasilar Stenosis: Pooled Data Analysis From Prospective Studies , 2013, Stroke.

[161]  Janine R Brodovsky,et al.  Vestibular Rehabilitation for Unilateral Peripheral Vestibular Dysfunction , 2013, Physical Therapy.

[162]  P. Rothwell,et al.  Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study , 2013, The Lancet Neurology.

[163]  H. Kamel,et al.  Rate and predictors of serious neurologic causes of dizziness in the emergency department. , 2012, Mayo Clinic proceedings.

[164]  D. Newman-Toker Symptoms and Signs of Neuro-otologic Disorders , 2012, Continuum.

[165]  T. Lempert Recurrent Spontaneous Attacks of Dizziness , 2012, Continuum.

[166]  Y. Nakagawa,et al.  Out-of-hospital scaling to recognize central vertigo. , 2012, The Tokai journal of experimental and clinical medicine.

[167]  D. Newman-Toker,et al.  Clinical Characteristics of Symptomatic Vertebral Artery Dissection: A Systematic Review , 2012, The neurologist.

[168]  Geoff Cohen,et al.  The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial , 2012, The Lancet.

[169]  S. Sidney,et al.  Practice variation in neuroimaging to evaluate dizziness in the ED. , 2012, The American journal of emergency medicine.

[170]  H. Kamel,et al.  Application of the ABCD2 Score to Identify Cerebrovascular Causes of Dizziness in the Emergency Department , 2012, Stroke.

[171]  R. Thomson,et al.  Shared Decision Making: A Model for Clinical Practice , 2012, Journal of General Internal Medicine.

[172]  Karen L. Furie,et al.  Comparative sensitivity of computed tomography vs. magnetic resonance imaging for detecting acute posterior fossa infarct. , 2012, The Journal of emergency medicine.

[173]  Yu-Chieh Su,et al.  Increased Risk of Vascular Events in Emergency Room Patients Discharged Home with Diagnosis of Dizziness or Vertigo: A 3-Year Follow-Up Study , 2012, PloS one.

[174]  M. Hilton,et al.  Modifications of the Epley (canalith repositioning) manoeuvre for posterior canal benign paroxysmal positional vertigo (BPPV). , 2012, The Cochrane database of systematic reviews.

[175]  O. Vysata,et al.  Symptoms and signs of posterior circulation ischemia in the new England medical center posterior circulation registry. , 2012, Archives of neurology.

[176]  P. Amarenco,et al.  Patients With Transient Ischemic Attack With ABCD2 <4 Can Have Similar 90-Day Stroke Risk as Patients With Transient Ischemic Attack With ABCD2 ≥4 , 2012, Stroke.

[177]  Gao Ji-jun Clinical Efficacy of Epley Procedure for Treatment of Benign Paroxysmal Positional Vertigo of Posterior Semicircular Canal , 2012 .

[178]  K. Oguz,et al.  Value of Magnetic Resonance Imaging and Audiology in the Emergency Department in Differential Diagnosis of Peripheral and Central Vertigo , 2012 .

[179]  R. Cydulka,et al.  Variables associated with discordance between emergency physician and neurologist diagnoses of transient ischemic attacks in the emergency department. , 2012, Annals of emergency medicine.

[180]  G. Christoforidis,et al.  Utility of head CT in the evaluation of vertigo/dizziness in the emergency department , 2012, Emergency Radiology.

[181]  G. Guyatt,et al.  GRADE guidelines: 8. Rating the quality of evidence--indirectness. , 2011, Journal of clinical epidemiology.

[182]  Gordon H Guyatt,et al.  GRADE guidelines: 7. Rating the quality of evidence--inconsistency. , 2011, Journal of clinical epidemiology.

[183]  Gordon H Guyatt,et al.  GRADE guidelines: 9. Rating up the quality of evidence. , 2011, Journal of clinical epidemiology.

[184]  S. Engelter,et al.  Outcomes of Intravenous Thrombolysis in Posterior Versus Anterior Circulation Stroke , 2011, Stroke.

[185]  M. Chung,et al.  The Effect of Early Canalith Repositioning on Benign Paroxysmal Positional Vertigo on Recurrence , 2011, Clinical and experimental otorhinolaryngology.

[186]  D. Newman-Toker,et al.  Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome , 2011, Canadian Medical Association Journal.

[187]  David E Newman-Toker,et al.  Nystagmus assessments documented by emergency physicians in acute dizziness presentations: a target for decision support? , 2011, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[188]  Angus Waddell,et al.  Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis). , 2011, The Cochrane database of systematic reviews.

[189]  Howard Balshem,et al.  GRADE guidelines: 3. Rating the quality of evidence. , 2011, Journal of clinical epidemiology.

[190]  Fatimah Lateef,et al.  Patient expectations and the paradigm shift of care in emergency medicine , 2011, Journal of emergencies, trauma, and shock.

[191]  G. Guyatt,et al.  GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. , 2011, Journal of clinical epidemiology.

[192]  G. Guyatt,et al.  GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias). , 2011, Journal of clinical epidemiology.

[193]  L. Lisabeth,et al.  Does intracerebral haemorrhage mimic benign dizziness presentations? A population based study , 2011, Emergency Medicine Journal.

[194]  G. Moretto,et al.  Ataxia in posterior circulation stroke: Clinical–MRI correlations , 2011, Journal of the Neurological Sciences.

[195]  H. Markus,et al.  The use of FAST and ABCD2 scores in posterior circulation, compared with anterior circulation, stroke and transient ischemic attack , 2011, Journal of Neurology, Neurosurgery & Psychiatry.

[196]  J. Grotta,et al.  Zero on the NIHSS does not equal the absence of stroke. , 2011, Annals of emergency medicine.

[197]  S. Johnston,et al.  Risk of vascular events in emergency department patients discharged home with diagnosis of dizziness or vertigo. , 2011, Annals of emergency medicine.

[198]  M. Ganança,et al.  Elderly falls associated with benign paroxysmal positional vertigo , 2015, Brazilian journal of otorhinolaryngology.

[199]  H. Dewey,et al.  Diagnostic accuracy of acute vestibular syndrome at the bedside in a stroke unit , 2011, Journal of Neurology.

[200]  Brady T. West,et al.  Value of computed tomography scans in ED dizziness visits: analysis from a nationally representative sample. , 2010, The American journal of emergency medicine.

[201]  M. Mlynash,et al.  Agreement Regarding Diagnosis of Transient Ischemic Attack Fairly Low Among Stroke-Trained Neurologists , 2010, Stroke.

[202]  Harris Chan,et al.  Predictors of important neurological causes of dizziness among patients presenting to the emergency department , 2010, Emergency Medicine Journal.

[203]  He Hui-yi The efficacy of Epley procedure for treatment of benign paroxysmal positional vertigo of the posterior semicircular canal , 2010 .

[204]  D. Miglioretti,et al.  Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. , 2009, Archives of internal medicine.

[205]  H. Markus,et al.  Noninvasive Detection of Vertebral Artery Stenosis: A Comparison of Contrast-Enhanced MR Angiography, CT Angiography, and Ultrasound , 2009, Stroke.

[206]  D. Newman-Toker,et al.  HINTS to Diagnose Stroke in the Acute Vestibular Syndrome: Three-Step Bedside Oculomotor Examination More Sensitive Than Early MRI Diffusion-Weighted Imaging , 2009, Stroke.

[207]  C. Camargo,et al.  Disconnect between charted vestibular diagnoses and emergency department management decisions: a cross-sectional analysis from a nationally representative sample. , 2009, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[208]  J. Schrock,et al.  Can the ABCD2 Risk Score Predict Positive Diagnostic Testing for Emergency Department Patients Admitted for Transient Ischemic Attack? , 2009, Stroke.

[209]  H. Markus,et al.  Vertebrobasilar Stenosis Predicts High Early Recurrent Stroke Risk in Posterior Circulation Stroke and TIA , 2009, Stroke.

[210]  R. Tusa,et al.  Unnecessary diagnostic tests often obtained for benign paroxysmal positional vertigo. , 2009, Medical science monitor : international medical journal of experimental and clinical research.

[211]  Michael C Schubert,et al.  Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004. , 2009, Archives of internal medicine.

[212]  R. Haberl,et al.  [Transient ischemic attack]. , 2009, MMW Fortschritte der Medizin.

[213]  M. Kaste,et al.  Analysis of 1008 Consecutive Patients Aged 15 to 49 With First-Ever Ischemic Stroke: The Helsinki Young Stroke Registry , 2009, Stroke.

[214]  P. Rothwell,et al.  Incidence and prognosis of > or = 50% symptomatic vertebral or basilar artery stenosis: prospective population-based study. , 2008, Brain : a journal of neurology.

[215]  H. Neuhauser,et al.  Vestibular migraine. , 2009, Neurologic clinics.

[216]  D. Newman-Toker,et al.  Diagnosis and initial management of cerebellar infarction , 2008, The Lancet Neurology.

[217]  Brady T. West,et al.  Dizziness presentations in U.S. emergency departments, 1995-2004. , 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[218]  David E Newman-Toker,et al.  Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. , 2008, Mayo Clinic proceedings.

[219]  D. Newman-Toker,et al.  Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis , 2008, Neurology.

[220]  R. Tusa,et al.  Practice Parameter: Therapies for benign paroxysmal positional vertigo (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of NeurologySYMBOLSYMBOLSYMBOL , 2008, Neurology.

[221]  Michael Strupp,et al.  Bedside differentiation of vestibular neuritis from central “vestibular pseudoneuritis” , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[222]  Arthur L. Kellermann,et al.  International survey of emergency physicians' priorities for clinical decision rules. , 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[223]  E. Thabet Evaluation of patients with acute vestibular syndrome , 2008, European Archives of Oto-Rhino-Laryngology.

[224]  P. Rothwell,et al.  Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis , 2007, The Lancet Neurology.

[225]  D. Brenner,et al.  Computed tomography--an increasing source of radiation exposure. , 2007, The New England journal of medicine.

[226]  P. Touboul,et al.  A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects , 2007, The Lancet Neurology.

[227]  C. Camargo,et al.  Overreliance on symptom quality in diagnosing dizziness: results of a multicenter survey of emergency physicians. , 2007, Mayo Clinic proceedings.

[228]  G. Lip,et al.  Atrial fibrillation and stroke prevention , 2007, The Lancet Neurology.

[229]  D. Zee,et al.  Imprecision in patient reports of dizziness symptom quality: a cross-sectional study conducted in an acute care setting. , 2007, Mayo Clinic proceedings.

[230]  S. Gutnikov,et al.  Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison , 2007, The Lancet.

[231]  W. Kaiser,et al.  Time course of diffusion imaging in acute brainstem infarcts , 2007, Journal of magnetic resonance imaging : JMRI.

[232]  D. Newman-Toker Charted records of dizzy patients suggest emergency physicians emphasize symptom quality in diagnostic assessment. , 2007, Annals of emergency medicine.

[233]  J. Kaczorowski,et al.  Canalith repositioning maneuver for benign paroxysmal positional vertigo: randomized controlled trial in family practice. , 2007, Canadian family physician Medecin de famille canadien.

[234]  Catherine Yoon,et al.  Missed and delayed diagnoses in the emergency department: a study of closed malpractice claims from 4 liability insurers. , 2007, Annals of emergency medicine.

[235]  M. Luby,et al.  Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison , 2007, The Lancet.

[236]  L. Caplan,et al.  Pitfalls in the diagnosis of cerebellar infarction. , 2007, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[237]  H. Neuhauser,et al.  Epidemiology of benign paroxysmal positional vertigo: a population based study , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[238]  L. Lisabeth,et al.  Stroke Among Patients With Dizziness, Vertigo, and Imbalance in the Emergency Department: A Population-Based Study , 2006, Stroke.

[239]  T. Rainer,et al.  The Epidemiology of Patients with Dizziness in an Emergency Department , 2006 .

[240]  H. Neuhauser,et al.  Short-term efficacy of Epley’s manoeuvre: a double-blind randomised trial , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[241]  L. Caplan,et al.  Current concepts: Vertebrobasilar disease , 2005 .

[242]  J. Newton,et al.  Benign paroxysmal positional vertigo: clinical characteristics of dizzy patients referred to a Falls and Syncope Unit. , 2005, QJM : monthly journal of the Association of Physicians.

[243]  R. Bakshi,et al.  Dizziness and yield of emergency head CT scan: Is it cost effective? , 2005, Emergency Medicine Journal.

[244]  J. Lopez-Escamez,et al.  Long-term outcome and health-related quality of life in benign paroxysmal positional vertigo , 2005, European Archives of Oto-Rhino-Laryngology and Head & Neck.

[245]  M. Hill,et al.  A randomized clinical trial to assess the efficacy of the Epley maneuver in the treatment of acute benign positional vertigo. , 2004, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[246]  J. Edlow,et al.  Transient ischemic attack: review for the emergency physician. , 2004, Annals of emergency medicine.

[247]  Jose A. Lopez-Escamez,et al.  Health-Related Quality of Life in Patients over Sixty Years Old with Benign Paroxysmal Positional Vertigo , 2004, Gerontology.

[248]  S. Sidney,et al.  Head Computed Tomography Findings Predict Short-Term Stroke Risk After Transient Ischemic Attack , 2003, Stroke.

[249]  P. Rothwell,et al.  Prognosis of vertebrobasilar transient ischaemic attack and minor stroke. , 2003, Brain : a journal of neurology.

[250]  J. Lopez-Escamez,et al.  Impact of Treatment on Health-Related Quality of Life in Patients with Posterior Canal Benign Paroxysmal Positional Vertigo , 2003, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[251]  K. Yimtae,et al.  A Randomized Trial of the Canalith Repositioning Procedure , 2003, The Laryngoscope.

[252]  D. Pinder,et al.  The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo. , 2002, The Cochrane database of systematic reviews.

[253]  David A. Froehling,et al.  The canalith repositioning procedure for the treatment of benign paroxysmal positional vertigo: a randomized controlled trial. , 2000, Mayo Clinic proceedings.

[254]  H. Jenkins,et al.  Unrecognized benign paroxysmal positional vertigo in elderly patients , 2000 .

[255]  W. Richardson,et al.  The well-built clinical question: a key to evidence-based decisions. , 1995, ACP journal club.

[256]  R. Baloh,et al.  Approach to the dizzy patient. , 1994, Bailliere's clinical neurology.

[257]  John M. Epley,et al.  The Canalith Repositioning Procedure: For Treatment of Benign Paroxysmal Positional Vertigo , 1992, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[258]  T. Price,et al.  Cooperative study of hospital frequency and character of transient ischemic attacks. I. Background, organization, and clinical survey. , 1977, JAMA.