Biologically engineered microstructures: controlled release applications

The area of self-assembled ultrafine particulate-based composites (nano composites) has been a major thrust in advanced material development. In this paper we report on the application of biologically derived, self-assembled cylindrical microstructures to form advanced composite materials for controlled release applications. These microstructures (we call them tubules) have many applications in the material sciences. This paper will focus on the potential for rationally controlling the fabrication of submicron microstructures for controlled release applications.

[1]  P. Dijke,et al.  Growth Factors For Wound Healing , 1989, Bio/Technology.

[2]  B. Spargo,et al.  Biocompatibility of lipid microcylinders: effect on cell growth and antigen presentation in culture. , 1992, Biomaterials.

[3]  R. Price,et al.  Controlled release from cylindrical microstructures. , 1991, Journal of microencapsulation.

[4]  B. Goins,et al.  In vivo biodistribution of a radiolabeled blood substitute: 99mTc-labeled liposome-encapsulated hemoglobin in an anesthetized rabbit. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Paul Yager,et al.  Lipid-based tubule microstructures☆ , 1987 .

[6]  Paul Yager,et al.  Formation of Tubules by a Polymerizable Surfactant , 1984 .

[7]  P. Yager,et al.  Helical and tubular microstructures formed by polymerizable phosphatidylcholines , 1987 .

[8]  A. Rudolph,et al.  Dry storage of liposome-encapsulated hemoglobin: a blood substitute. , 1990, Cryobiology.

[9]  J. Calvert,et al.  Interaction of metallized tubules with electromagnetic radiation , 1990 .

[10]  J M Davidson,et al.  Sustained release of epidermal growth factor accelerates wound repair. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Anthony S. Clare,et al.  Performance enhancement of natural antifouling compounds and their analogs through microencapsulation and controlled release , 1992 .

[12]  F. Rachford,et al.  Artificial dielectric properties of microscopic metallized filaments in composites , 1991 .

[13]  B. Spargo,et al.  Technological Development of Lipid-Based Microcylinders: Biocompatibility and Controlled Release , 1991 .

[14]  R. Price,et al.  Entrapment and release characteristics of 2-methoxynaphthalene from cylindrical microstructures formed from phospholipids. , 1993, Journal of microencapsulation.

[15]  R Langer,et al.  Controlled and modulated release of basic fibroblast growth factor. , 1991, Biomaterials.

[16]  P. Cullis,et al.  Use of liposomes as injectable-drug delivery systems. , 1989, American journal of hospital pharmacy.

[17]  F. Ligler,et al.  Liposome-encapsulated hemoglobin: an oxygen-carrying fluid. , 1990, Circulatory shock.