Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

[1]  M. Magnuson,et al.  Cell-specific roles of glucokinase in glucose homeostasis. , 2001, Recent progress in hormone research.

[2]  M. Magnuson,et al.  Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.

[3]  C. Kahn,et al.  A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. , 1998, Molecular cell.

[4]  P. Berggren,et al.  Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. , 1998, Molecular cell.

[5]  G. Shulman,et al.  Disruption of IRS-2 causes type 2 diabetes in mice , 1998, Nature.

[6]  C. Kahn,et al.  Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. , 1997, The Journal of clinical investigation.

[7]  D. Smith,et al.  Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. , 1997, The Journal of clinical investigation.

[8]  D. Cook,et al.  Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1 , 1997, Diabetologia.

[9]  C. Kahn,et al.  Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles , 1997, Cell.

[10]  David J. Anderson,et al.  Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain , 1996, Cell.

[11]  B. Wolf,et al.  Expression of Insulin Receptor mRNA and Insulin Receptor Substrate 1 in Pancreatic Islet β-Cells , 1996, Diabetes.

[12]  B. Lamothe,et al.  Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. , 1996, EMBO Journal.

[13]  P. Berggren,et al.  Fluorescence-activated cell sorted rat islet cells and studies of the insulin secretory process. , 1996, The Journal of endocrinology.

[14]  J. Halter,et al.  Maturity Onset Diabetes of the Young (MODY) , 1989, Diabetic medicine : a journal of the British Diabetic Association.

[15]  R. Robertson,et al.  AN INTEGRATED VIEW OF β-CELL DYSFUNCTION IN TYPE-II DIABETES , 1996 .

[16]  Mark D. Johnson,et al.  Early neonatal death in mice homozygous for a null allele of the insulin receptor gene , 1996, Nature Genetics.

[17]  L. Velloso,et al.  Glucose‐ and insulin‐induced phosphorylation of the insulin receptor and its primary substrates IRS‐1 and IRS‐2 in rat pancreatic islets , 1995, FEBS letters.

[18]  M Aguet,et al.  Inducible gene targeting in mice , 1995, Science.

[19]  P. Chambon,et al.  Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[20]  B. Wolf,et al.  Glucose-Induced Insulin Receptor Tyrosine Phosphorylation in Insulin-Secreting β-Cells , 1995, Diabetes.

[21]  K. Polonsky.  The β-Cell in Diabetes: From Molecular Genetics to Clinical Research , 1995, Diabetes.

[22]  J. Olefsky,et al.  Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms. , 1995, The American journal of clinical nutrition.

[23]  C. Kahn,et al.  Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.

[24]  T. Yagi,et al.  Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 , 1994, Nature.

[25]  C. R. Kahn,et al.  Insulin Action, Diabetogenes, and the Cause of Type II Diabetes , 1994, Diabetes.

[26]  K. Rajewsky,et al.  Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. , 1994, Science.

[27]  E. Ravussin,et al.  Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. , 1993, The New England journal of medicine.

[28]  J. Sturis,et al.  Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. , 1993, The Journal of clinical investigation.

[29]  A. Joyner,et al.  Production of targeted embryonic stem cell clones. , 1993 .

[30]  W. Sheu,et al.  Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. , 1993, The Journal of clinical endocrinology and metabolism.

[31]  I. Godsland,et al.  Role of glucose and insulin resistance in development of type 2 diabetes mellitus , 1992, The Lancet.

[32]  Simeon I. Taylor,et al.  Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene , 1992, Diabetes.

[33]  R. N. Bergman,et al.  Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study , 1992, The Lancet.

[34]  J. Leahy,et al.  The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment. , 1992, The Journal of clinical investigation.

[35]  M. Magnuson,et al.  Heterogeneous expression of glucokinase among pancreatic beta cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[36]  J. Beckmann,et al.  Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus , 1992, Nature.

[37]  J. Leahy,et al.  β-Cell Dysfunction Induced by Chronic Hyperglycemia: Current Ideas on Mechanism of Impaired Glucose-Induced Insulin Secretion , 1992, Diabetes Care.

[38]  Ko Yh,et al.  [Insulin resistance and non-insulin dependent diabetes mellitus]. , 1992 .

[39]  R. Unger,et al.  Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells. , 1991, Science.

[40]  D. Porte.  β-cells in type II diabetes mellitus , 1991, Diabetes.

[41]  N. Paquot,et al.  [Beta cells in Type II diabetes: culprit or victim?]. , 1991, Journees annuelles de diabetologie de l'Hotel-Dieu.

[42]  E. Verspohl,et al.  Indirect evidence for short-loop negative feedback of insulin secretion in the rat. , 1991, The Journal of endocrinology.

[43]  A. Krolewski,et al.  Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. , 1990, Annals of internal medicine.

[44]  T. Mandel,et al.  The evolution of function and response to arginine challenge and pregnancy of portally and systemically placed islet cell grafts in streptozotocin diabetic mice. , 1990, Metabolism: clinical and experimental.

[45]  J. Leahy,et al.  Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion. , 1990, Endocrinology.

[46]  D. Owens,et al.  INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES , 1989, The Lancet.

[47]  J. Leahy,et al.  Compensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion , 1989, Diabetes.

[48]  G. Reaven.  Role of Insulin Resistance in Human Disease , 1988, Diabetes.

[49]  R. DeFronzo.  The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM , 1988, Diabetes.

[50]  S. O’Rahilly,et al.  Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. , 1988, The New England journal of medicine.

[51]  S. O’Rahilly,et al.  Pathogenesis of NIDDM--a disease of deficient insulin secretion. , 1988, Bailliere's clinical endocrinology and metabolism.

[52]  V. Grill,et al.  Low insulin response: a marker of prediabetes. , 1988, Advances in experimental medicine and biology.

[53]  S. Efendić.  Pathogenesis of NIDDM. , 1988, Diabetes research and clinical practice.

[54]  D. Pipeleers,et al.  Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cells. , 1987, Endocrinology.

[55]  R. Eaton,et al.  Insulin Suppresses Its Own Secretion In Vivo , 1987, Diabetes.

[56]  E. Cerasi,et al.  Insulin deficiency and insulin resistance in Type 2 (non‐insulin‐dependent) diabetes: quantitative contributions of pancreatic and peripheral responses to glucose homeostasis , 1987, European journal of clinical investigation.

[57]  G. Dohm,et al.  Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. , 1987, The Journal of clinical investigation.

[58]  V. Rogiers,et al.  Pancreatic hormone receptors on islet cells. , 1985, Endocrinology.

[59]  B V Howard,et al.  Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. , 1984, The Journal of clinical investigation.

[60]  S. Bonner-Weir,et al.  Abnormal Islet and Adipocyte Function in Young B-cell-deficient Rats with Near-Normoglycemia , 1984, Diabetes.

[61]  L. Orci,et al.  Quantitative electron microscopic autoradiography of insulin, glucagon, and somatostatin binding sites on islets. , 1982, Science.

[62]  J. Tobin,et al.  Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity. , 1982, The New England journal of medicine.

[63]  J. Halter,et al.  Insulin Responses to Nonglucose Stimuli in Non-insulin-dependent Diabetes Mellitus During a Tolbutamide Infusion , 1982, Diabetes.

[64]  J. P. Moulin,et al.  The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia. , 1982, Metabolism: clinical and experimental.

[65]  R. Robertson,et al.  A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics. , 1981, Metabolism: clinical and experimental.

[66]  E. Verspohl,et al.  Evidence for presence of insulin receptors in rat islets of Langerhans. , 1980, The Journal of clinical investigation.

[67]  C. Kahn,et al.  Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance , 1975, Science.

[68]  E. Cerasi,et al.  Decreased Sensitivity of the Pancreatic Beta Cells to Glucose in Prediabetic and Diabetic Subjects: A Glucose Dose-Response Study , 1972, Diabetes.

[69]  J. Iversen,et al.  Evidence for a Feedback Inhibition of Insulin on Insulin Secretion in the Isolated, Perfused Canine Pancreas , 1971, Diabetes.

[70]  F. Plum.  Handbook of Physiology. , 1960 .

[71]  R. Baquet.  [Endocrine pancreas]. , 1950, Maroc medical.