Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction

[1]  A. Halayko,et al.  Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma. , 2006, Mini reviews in medicinal chemistry.

[2]  H. Meurs,et al.  Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations. , 2006, European journal of pharmacology.

[3]  R. Gosens,et al.  Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction , 2005, Respiratory research.

[4]  P. Henry,et al.  A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice. , 2005, Pulmonary pharmacology & therapeutics.

[5]  H. Sakai,et al.  Involvement of RhoA-mediated Ca2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice , 2005, Respiratory research.

[6]  R. Gosens,et al.  Allergic sensitization enhances the contribution of Rho‐kinase to airway smooth muscle contraction , 2004, British journal of pharmacology.

[7]  R. Gosens,et al.  Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinase-dependent. , 2004, European journal of pharmacology.

[8]  K. Dobashi,et al.  Comparison of effects of Y-27632 and Isoproterenol on release of cytokines from human peripheral T cells. , 2003, International immunopharmacology.

[9]  A. Somlyo,et al.  Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. , 2003, Physiological reviews.

[10]  S. Offermanns,et al.  Rho/Rho-kinase mediated signaling in physiology and pathophysiology , 2002, Journal of Molecular Medicine.

[11]  H. S. Sharma,et al.  Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle , 2001, Respiratory research.

[12]  A. Sampson,et al.  The role of eosinophils and neutrophils in inflammation. , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  S. Miyamoto,et al.  Augmented acetylcholine‐induced, Rho‐mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen‐induced airway hyperresponsive rats , 1999, British journal of pharmacology.

[14]  K. Chung,et al.  Prostaglandins E2 and F2alpha reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway caliber changes. , 1998, American journal of respiratory and critical care medicine.

[15]  T. W. van der Mark,et al.  A novel method to assess airway function parameters in chronically instrumented, unrestrained guinea-pigs. , 1992, Pulmonary pharmacology.

[16]  S. Durham,et al.  Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses. , 1988, The Journal of allergy and clinical immunology.

[17]  P. O'Byrne,et al.  Mediators, airway responsiveness, and asthma. , 1985, The Journal of allergy and clinical immunology.

[18]  R. Gosens,et al.  Contribution of Rho-kinase (ROCK) to airway smooth muscle (ASM) contraction after allergic sensitization , 2005 .

[19]  F. Brouwer,et al.  Analysis of theβ-adrenoceptor mediated inhibition of IgG1 and IgE dependent guinea-pig anaphylactic tracheal smooth muscle contraction , 2005, Agents and Actions.

[20]  K. Kaibuchi,et al.  Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. , 2001, Trends in pharmacological sciences.

[21]  F. Brouwer,et al.  Analysis of the beta-adrenoceptor mediated inhibition of IgG1 and IgE dependent guinea-pig anaphylactic tracheal smooth muscle contraction. , 1989, Agents and actions.

[22]  D. Cockcroft Nonallergic airway responsiveness. , 1988, The Journal of allergy and clinical immunology.

[23]  G. Pfitzer highlighted topics Signal Transduction in Smooth Muscle Invited Review: Regulation of myosin phosphorylation in smooth muscle , 2022 .