Restoration From Acute Urinary Dysfunction Using Utah Electrode Arrays Implanted Into the Feline Pudendal Nerve

To investigate intrafascicular pudendal nerve stimulation in felines as a means to restore urinary function in acute models of urinary incontinence, overactive bladder, and underactive bladder.

[1]  J. Boura,et al.  Chronic pudendal neuromodulation: Expanding available treatment options for refractory urologic symptoms , 2010, Neurourology and urodynamics.

[2]  Warren M Grill,et al.  Model-based analysis and design of nerve cuff electrodes for restoring bladder function by selective stimulation of the pudendal nerve , 2013, Journal of neural engineering.

[3]  R. Normann,et al.  Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex , 1998, Journal of Neuroscience Methods.

[4]  D. J. Warren,et al.  Acute monitoring of genitourinary function using intrafascicular electrodes: selective pudendal nerve activity corresponding to bladder filling, bladder fullness, and genital stimulation. , 2014, Urology.

[5]  R. Stein,et al.  Selective stimulation of cat sciatic nerve using an array of varying-length microelectrodes. , 2001, Journal of neurophysiology.

[6]  Warren M Grill,et al.  A urethral afferent mediated excitatory bladder reflex exists in humans , 2004, Neuroscience Letters.

[7]  E. Chartier-Kastler,et al.  Peripheral neural lesion‐induced stress urinary incontinence in anaesthetized female cats , 2008, BJU international.

[8]  H A C Wark,et al.  Behavioral and cellular consequences of high-electrode count Utah Arrays chronically implanted in rat sciatic nerve , 2014, Journal of neural engineering.

[9]  Richard A. Normann,et al.  Selective Activation of the Muscles of Micturition Using Intrafascicular Stimulation of the Pudendal Nerve , 2011, IEEE Journal on Emerging and Selected Topics in Circuits and Systems.

[10]  D. Vodušek,et al.  Detrusor inhibition induced by stimulation of pudendal nerve afferents , 1986 .

[11]  W. Artibani,et al.  Electrical stimulation of the dorsal nerve of the penis evokes reflex tonic erections of the penile body and reflex ejaculatory responses in the spinal rat. , 1993, The Journal of urology.

[12]  Warren M Grill,et al.  Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury , 2007, Neurourology and urodynamics.

[13]  J. Silverman,et al.  A review of laboratory animal anesthesia with chloral hydrate and chloralose. , 1993, Laboratory animal science.

[14]  Jia-Jin Chen,et al.  External urethral sphincter activity in a rat model of pudendal nerve injury , 2006, Neurourology and urodynamics.

[15]  F. Rattay Analysis of models for extracellular fiber stimulation , 1989, IEEE Transactions on Biomedical Engineering.

[16]  J. Roppolo,et al.  Pudendal-to-bladder reflex in chronic spinal-cord-injured cats , 2006, Experimental Neurology.

[17]  Lukas Marti,et al.  First experiences with pudendal nerve stimulation in fecal incontinence: a technical report , 2010, Techniques in Coloproctology.

[18]  R. Normann,et al.  A method for pneumatically inserting an array of penetrating electrodes into cortical tissue , 2006, Annals of Biomedical Engineering.

[19]  Warren M. Grill,et al.  Fascicular anatomy and surgical access of the human pudendal nerve , 2005, World Journal of Urology.

[20]  D. Rudy,et al.  alpha-Chloralose alters autonomic reflex function of the lower urinary tract. , 1991, The American journal of physiology.

[21]  Warren M Grill,et al.  Closed loop electrical control of urinary continence. , 2006, The Journal of urology.

[22]  K J Gustafson,et al.  The Feline Dorsal Nerve of the Penis Arises from the Deep Perineal Nerve and Not the Sensory Afferent Branch , 2008, Anatomia, histologia, embryologia.

[23]  Warren M Grill,et al.  Frequency‐dependent selection of reflexes by pudendal afferents in the cat , 2006, The Journal of physiology.

[24]  P. Tresco,et al.  A new high-density (25 electrodes/mm2) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures , 2013, Journal of neural engineering.

[25]  R. Normann,et al.  Assessment of rat sciatic nerve function following acute implantation of high density utah slanted electrode array (25 electrodes/mm2) based on neural recordings and evoked muscle activity , 2014, Muscle & nerve.

[26]  Michele Spinelli,et al.  A new minimally invasive procedure for pudendal nerve stimulation to treat neurogenic bladder: Description of the method and preliminary data , 2005, Neurourology and urodynamics.

[27]  E. Opisso,et al.  Patient controlled versus automatic stimulation of pudendal nerve afferents to treat neurogenic detrusor overactivity. , 2008, The Journal of urology.

[28]  Warren M. Grill,et al.  Bladder activation by selective stimulation of pudendal nerve afferents in the cat , 2008, Experimental Neurology.