Sodium citrate blood contamination by K2‐ethylenediaminetetraacetic acid (EDTA): impact on routine coagulation testing

The potential cross‐contamination of additives between primary blood tubes is a well‐known problem during sample collection. The aim of this study was to assess the impact of citrated blood contamination with different amounts of dipotassium ethylenediaminetetraacetic (K2EDTA blood) on activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen.

[1]  U. Pennsylvania,et al.  Clinical and Laboratory Standards Institute , 2019, Springer Reference Medizin.

[2]  W. Schuermans,et al.  The order of draw: much ado about nothing? , 2015, International journal of laboratory hematology.

[3]  G. Lippi,et al.  Combined Administration of Antibiotics and Direct Oral Anticoagulants: A Renewed Indication for Laboratory Monitoring? , 2014, Seminars in Thrombosis & Hemostasis.

[4]  G. Lippi,et al.  Urgent monitoring of direct oral anticoagulants in patients with atrial fibrillation: a tentative approach based on routine laboratory tests , 2014, Journal of Thrombosis and Thrombolysis.

[5]  K. Kottke-Marchant.  Algorithmic Approaches to Hemostasis Testing , 2014, Seminars in Thrombosis & Hemostasis.

[6]  G. Lippi,et al.  The effective reduction of tourniquet application time after minor modification of the CLSI H03-A6 blood collection procedure , 2013, Biochemia medica.

[7]  G. Lippi,et al.  The order of draw: myth or science? , 2013, Clinical chemistry and laboratory medicine.

[8]  G. Lippi,et al.  Incorrect order of draw could be mitigate the patient safety: a phlebotomy management case report , 2013, Biochemia medica.

[9]  G. Lippi,et al.  Sodium citrate vacuum tubes validation: preventing preanalytical variability in routine coagulation testing , 2013, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[10]  G. Lippi,et al.  Quality Standards for Sample Processing, Transportation, and Storage in Hemostasis Testing , 2012, Seminars in Thrombosis & Hemostasis.

[11]  G. Lippi,et al.  Quality Standards for Sample Collection in Coagulation Testing , 2012, Seminars in Thrombosis & Hemostasis.

[12]  Giuseppe Lippi,et al.  Pre-analytical Variables in Coagulation Testing Associated With Diagnostic Errors in Hemostasis , 2012 .

[13]  L. Joutsi-Korhonen,et al.  Active Online Assessment of Patients Using New Oral Anticoagulants: Bleeding Risk, Compliance, and Coagulation Analysis , 2012, Seminars in Thrombosis & Hemostasis.

[14]  G. Lippi,et al.  Laboratory testing of anticoagulants: the present and the future , 2011, Pathology.

[15]  G. Lippi,et al.  Right or wrong sample received for coagulation testing? Tentative algorithms for detection of an incorrect type of sample , 2010, International journal of laboratory hematology.

[16]  R. Gama,et al.  EDTA sample contamination is common and often undetected, putting patients at unnecessary risk of harm , 2009, International journal of clinical practice.

[17]  R. Zadro,et al.  Evaluation and performance characteristics of the coagulation system: ACL TOP analyzer – HemosIL reagents , 2009, International journal of laboratory hematology.

[18]  G. Lippi,et al.  Preanalytical and Postanalytical Variables: The Leading Causes of Diagnostic Error in Hemostasis? , 2008, Seminars in thrombosis and hemostasis.

[19]  E. Duncan,et al.  Mis‐identification of factor inhibitors by diagnostic haemostasis laboratories: recognition of pitfalls and elucidation of strategies. A follow up to a large multicentre evaluation , 2007, Pathology.

[20]  G. Lippi,et al.  The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes , 2007, Clinical chemistry and laboratory medicine.

[21]  E. Duncan,et al.  Identification of factor inhibitors by diagnostic haemostasis laboratories , 2006, Thrombosis and Haemostasis.

[22]  C Ricós,et al.  Current databases on biological variation: pros, cons and progress. , 1999, Scandinavian journal of clinical and laboratory investigation.