Signal transduction pathways regulating hematopoietic differentiation.

Hematopoiesis, the process by which pluripotent stem cells give rise to functionally diverse mature blood cells, involves a complex array of hematopoietic growth factors. These factors regulate the survival and proliferation of early progenitors, influence differentiation commitment, and modulate

[1]  L. Samelson,et al.  T cell antigen-receptor signal transduction. , 1999, Current opinion in immunology.

[2]  R. Jove,et al.  Activation of STAT3 by the c-Fes Protein-tyrosine Kinase* , 1998, The Journal of Biological Chemistry.

[3]  R. Jove,et al.  Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[4]  T. Smithgall,et al.  Oligomerization of the Fes Tyrosine Kinase , 1997, The Journal of Biological Chemistry.

[5]  Mario Stevenson,et al.  SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1* , 1997, The Journal of Biological Chemistry.

[6]  H. Beug,et al.  STAT5 involvement in the differentiation response of primary chicken myeloid progenitor cells to chicken myelomonocytic growth factor. , 1997, Journal of immunology.

[7]  A. Kraft,et al.  The Cytoplasmic Domain of Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Receptor α Subunit Is Essential for Both GM-CSF-mediated Growth and Differentiation* , 1997, The Journal of Biological Chemistry.

[8]  S. Anderson,et al.  Binding of src-like Kinases to the β-Subunit of the Interleukin-3 Receptor* , 1997, The Journal of Biological Chemistry.

[9]  E. Nishida,et al.  Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3. , 1997, Blood.

[10]  D. Morrison,et al.  The complexity of Raf-1 regulation. , 1997, Current opinion in cell biology.

[11]  S. Klinken,et al.  Lyn tyrosine kinase is essential for erythropoietin‐induced differentiation of J2E erythroid cells , 1997, The EMBO journal.

[12]  M. Cobb,et al.  Mitogen-activated protein kinase pathways. , 1997, Current opinion in cell biology.

[13]  J. Parsons,et al.  Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. , 1997, Current opinion in cell biology.

[14]  N. Ahn,et al.  Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase , 1997, Molecular and cellular biology.

[15]  C. Der,et al.  Lck regulates Vav activation of members of the Rho family of GTPases , 1997, Molecular and cellular biology.

[16]  John Kuriyan,et al.  Crystal structure of the Src family tyrosine kinase Hck , 1997, Nature.

[17]  Michael J. Eck,et al.  Three-dimensional structure of the tyrosine kinase c-Src , 1997, Nature.

[18]  M. Kuo,et al.  Characterization of factor-independent variants derived from TF-1 hematopoietic progenitor cells: the role of the Raf/MAP kinase pathway in the anti-apoptotic effect of GM-CSF , 1997, Oncogene.

[19]  F. McCormick,et al.  Signal transduction from multiple Ras effectors. , 1997, Current opinion in genetics & development.

[20]  M. Jücker,et al.  The Fes Protein-Tyrosine Kinase Phosphorylates a Subset of Macrophage Proteins That Are Involved in Cell Adhesion and Cell-Cell Signaling* , 1997, The Journal of Biological Chemistry.

[21]  K. Schuebel,et al.  Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product , 1997, Nature.

[22]  S. Schreiber,et al.  Regulatory intramolecular association in a tyrosine kinase of the Tec family , 1997, Nature.

[23]  T. Smithgall,et al.  Co-expression with BCR Induces Activation of the FES Tyrosine Kinase and Phosphorylation of Specific N-terminal BCR Tyrosine Residues* , 1996, The Journal of Biological Chemistry.

[24]  G. Stark,et al.  Regulation of STAT‐dependent pathways by growth factors and cytokines , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  John Calvin Reed,et al.  Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria , 1996, Cell.

[26]  B. Neel,et al.  From Form to Function: Signaling by Protein Tyrosine Phosphatases , 1996, Cell.

[27]  M. Shibuya,et al.  A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL‐3. , 1996, The EMBO journal.

[28]  G. Krystal,et al.  Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. , 1996, Blood.

[29]  K. Xia,et al.  The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Arai,et al.  Roles of the JAK-STAT system in signal transduction via cytokine receptors. , 1996, Current opinion in genetics & development.

[31]  S. Orkin.  Development of the hematopoietic system. , 1996, Current opinion in genetics & development.

[32]  M. Gishizky,et al.  Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[33]  S. Galli,et al.  Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1 , 1996, The Journal of experimental medicine.

[34]  Y. Yamashita,et al.  Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[35]  A. Wittinghofer,et al.  Interactions between Ras proteins and their effectors. , 1996, Current opinion in biotechnology.

[36]  B. Avalos,et al.  Molecular analysis of the granulocyte colony-stimulating factor receptor. , 1996, Blood.

[37]  J. Haigh,et al.  The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-golgi network. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[38]  T. Hirano,et al.  A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells. , 1996, The EMBO journal.

[39]  O. Witte,et al.  Regulation of Btk by Src family tyrosine kinases , 1996, Molecular and cellular biology.

[40]  P G Pelicci,et al.  Not all Shc's roads lead to Ras. , 1996, Trends in biochemical sciences.

[41]  A. Bernstein,et al.  Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1 , 1996, Nature Genetics.

[42]  M. T. Brown,et al.  Regulation, substrates and functions of src. , 1996, Biochimica et biophysica acta.

[43]  C. Lowell,et al.  Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions , 1996, The Journal of cell biology.

[44]  A. Miyajima,et al.  Suppression of interleukin‐3‐induced gene expression by a C‐terminal truncated Stat5: role of Stat5 in proliferation. , 1996, The EMBO journal.

[45]  S. Akira,et al.  STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[46]  L. Johnson,et al.  Active and Inactive Protein Kinases: Structural Basis for Regulation , 1996, Cell.

[47]  C. Gurniak,et al.  Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. , 1996, Blood.

[48]  S. Jaken.  Protein kinase C isozymes and substrates. , 1996, Current opinion in cell biology.

[49]  Y. Yamashita,et al.  Tec protein‐tyrosine kinase is an effector molecule of Lyn proteni‐tyroenie kinase , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[50]  R. Treisman,et al.  Regulation of transcription by MAP kinase cascades. , 1996, Current opinion in cell biology.

[51]  Y. Zheng,et al.  The Dbl family of oncogenes. , 1996, Current opinion in cell biology.

[52]  T. Hirano,et al.  Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. , 1996, The EMBO journal.

[53]  T. Graf,et al.  Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity. , 1996, The EMBO journal.

[54]  F. J. Luque,et al.  Theoretical Methods for the Representation of Solvent , 1996 .

[55]  P. Dent,et al.  Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation , 1996, Molecular and cellular biology.

[56]  M. Brizzi,et al.  Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93, STAT1 p91, and STAT3 p92 in Polymorphonuclear Leukocytes (*) , 1996, The Journal of Biological Chemistry.

[57]  J. Ihle.  STATs: Signal Transducers and Activators of Transcription , 1996, Cell.

[58]  A. Petros,et al.  Structure and ligand recognition of the phosphotyrosine binding domain of Shc , 1995, Nature.

[59]  A. Newton,et al.  Protein Kinase C: Structure, Function, and Regulation (*) , 1995, The Journal of Biological Chemistry.

[60]  Victor L. J. Tybulewicz,et al.  Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk , 1995, Nature.

[61]  Tony Pawson,et al.  Syk tyrosine kinase required for mouse viability and B-cell development , 1995, Nature.

[62]  P. Doherty,et al.  Defective Lymphoid Development in Mice Lacking Jak3 , 1995, Science.

[63]  A. Sharpe,et al.  Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3 , 1995, Science.

[64]  A. Yoshikawa,et al.  Distinct signal transduction through the tyrosine‐containing domains of the granulocyte colony‐stimulating factor receptor. , 1995, The EMBO journal.

[65]  G M Bokoch,et al.  Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[66]  Jonathan A. Cooper,et al.  Rho family members: Activators of MAP kinase cascades , 1995, Cell.

[67]  H. Mano,et al.  Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. , 1995, Oncogene.

[68]  S. Anderson,et al.  Activation of src-related tyrosine kinases by IL-3. , 1995, Journal of immunology.

[69]  A. Bernstein,et al.  Receptor tyrosine kinases and the regulation of hematopoiesis. , 1995, Seminars in immunology.

[70]  T. Wong,et al.  The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors , 1995, Molecular and cellular biology.

[71]  O. Witte,et al.  The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function. , 1995, Seminars in immunology.

[72]  P. Lowry.  Hematopoietic stem cell cytokine response , 1995, Journal of cellular biochemistry.

[73]  C. Marshall,et al.  Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. , 1995, The EMBO journal.

[74]  Yong‐Tae Kim,et al.  The SH2 Domains of Src Family Kinases Associate with Syk (*) , 1995, The Journal of Biological Chemistry.

[75]  R. Jove,et al.  The Ras GTPase-activating Protein (GAP) Is an SH3 Domain-binding Protein and Substrate for the Src-related Tyrosine Kinase, Hck (*) , 1995, Journal of Biological Chemistry.

[76]  A. Kraft,et al.  The Amino-terminal Portion of the JAK2 Protein Kinase Is Necessary For Binding and Phosphorylation of the Granulocyte-Macrophage Colony-stimulating Factor Receptor β Chain (*) , 1995, The Journal of Biological Chemistry.

[77]  H. Dombret,et al.  All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia. , 1995, Blood.

[78]  T. Graf,et al.  GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. , 1995, Genes & development.

[79]  T. Hirano,et al.  Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association , 1995, The Journal of Biological Chemistry.

[80]  A. Satterthwaite,et al.  Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. , 1995, Immunity.

[81]  T. Taniguchi.  Cytokine signaling through nonreceptor protein tyrosine kinases. , 1995, Science.

[82]  M. Barbacid,et al.  Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes , 1995, Nature.

[83]  K. Rajewsky,et al.  Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav , 1995, Nature.

[84]  Stuart H. Orkin,et al.  Transcription Factors and Hematopoietic Development (*) , 1995, The Journal of Biological Chemistry.

[85]  Ursula Klingmüller,et al.  Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals , 1995, Cell.

[86]  T. Pawson,et al.  Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit. , 1995, Oncogene.

[87]  T. Enver,et al.  Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3 (*) , 1995, The Journal of Biological Chemistry.

[88]  Tony Pawson,et al.  Protein modules and signalling networks , 1995, Nature.

[89]  T. Kishimoto,et al.  Signaling mechanisms through cytokine receptors that share signal transducing receptor components. , 1995, Current opinion in immunology.

[90]  S. Shoelson,et al.  Interaction of Shc with Grb2 regulates association of Grb2 with mSOS , 1995, Molecular and cellular biology.

[91]  O. Witte,et al.  Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS , 1995, Molecular and cellular biology.

[92]  T. Hirano,et al.  Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines. , 1995, Blood.

[93]  D. Baltimore,et al.  Modular binding domains in signal transduction proteins , 1995, Cell.

[94]  C. Heldin,et al.  Dimerization of cell surface receptors in signal transduction , 1995, Cell.

[95]  Y. Yazaki,et al.  Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway. , 1995, Blood.

[96]  M. Barbacid,et al.  The vav proto‐oncogene is required early in embryogenesis but not for hematopoietic development in vitro. , 1995, The EMBO journal.

[97]  B. Druker,et al.  Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM‐CSF, IL‐3 and steel factor and is constitutively increased by p210BCR/ABL. , 1995, The EMBO journal.

[98]  S. Orkin,et al.  Hematopoietic development of vav-/- mouse embryonic stem cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[99]  H. Mano,et al.  Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding , 1994, Molecular and cellular biology.

[100]  A. Leutz,et al.  Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepression. , 1994, Genes & development.

[101]  J. Schlessinger,et al.  Regulation of signal transduction and signal diversity by receptor oligomerization. , 1994, Trends in biochemical sciences.

[102]  C. Guillouf,et al.  Induction of p21 (WAF-1/CIP1) during differentiation. , 1994, Oncogene.

[103]  J. Griffin,et al.  Inhibition of p21ras activation blocks proliferation but not differentiation of interleukin-3-dependent myeloid cells. , 1994, The Journal of biological chemistry.

[104]  T. Pawson,et al.  The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice , 1994, Molecular and cellular biology.

[105]  C. Der,et al.  Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras , 1994, Molecular and cellular biology.

[106]  G. Krystal,et al.  Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc , 1994, Molecular and cellular biology.

[107]  E. Huberman,et al.  Protein kinase C-beta is required for macrophage differentiation of human HL-60 leukemia cells. , 1994, The Journal of biological chemistry.

[108]  K. Katagiri,et al.  Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells. , 1994, Blood.

[109]  J. Haines,et al.  Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1 , 1994, Annals of human genetics.

[110]  T J Gibson,et al.  PH domain: the first anniversary. , 1994, Trends in biochemical sciences.

[111]  J. Ihle,et al.  Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo. , 1994, Blood.

[112]  S. Krajewski,et al.  Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. , 1994, Oncogene.

[113]  D. Baltimore,et al.  Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[114]  M. Barbacid,et al.  Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor. , 1994, Oncogene.

[115]  J. Cleveland,et al.  v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. , 1994, Oncogene.

[116]  S. Rane,et al.  JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells. , 1994, Oncogene.

[117]  K. Izuhara,et al.  Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor. , 1994, The Journal of biological chemistry.

[118]  D. Longo,et al.  Hck expression correlates with granulocyte-macrophage colony-stimulating factor-induced proliferation in HL-60 cells. , 1994, Blood.

[119]  A. Wittinghofer,et al.  Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides , 1994, Molecular and cellular biology.

[120]  G. Dreyfuss,et al.  Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains , 1994, Molecular and cellular biology.

[121]  N. Sato,et al.  JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region , 1994, Molecular and cellular biology.

[122]  S. Orkin,et al.  Phosphorylation of the erythroid transcription factor GATA-1. , 1994, The Journal of biological chemistry.

[123]  S. Corey,et al.  Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[124]  N. Kohl,et al.  Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic , 1994, Cell.

[125]  N. Sato,et al.  Multimeric cytokine receptors: common versus specific functions. , 1994, Current opinion in cell biology.

[126]  A. Dunn,et al.  Functional and biochemical association of Hck with the LIF/IL‐6 receptor signal transducing subunit gp130 in embryonic stem cells. , 1994, The EMBO journal.

[127]  J. Griffin,et al.  p210Bcr/Abl and p160v-Abl induce an increase in the tyrosine phosphorylation of p93c-Fes. , 1994, The Journal of biological chemistry.

[128]  A. Yoshimura,et al.  Proliferation and erythroid differentiation through the cytoplasmic domain of the erythropoietin receptor. , 1994, The Journal of biological chemistry.

[129]  R. Salgia,et al.  Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL. , 1994, The Journal of biological chemistry.

[130]  H. Varmus,et al.  Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. , 1994, Genes & development.

[131]  M. Resh,et al.  Myristylation and palmitylation of Src family members: The fats of the matter , 1994, Cell.

[132]  L. Platanias,et al.  Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells. , 1994, The Journal of biological chemistry.

[133]  A. Wittinghofer,et al.  Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein , 1994, Molecular and cellular biology.

[134]  D. Kufe,et al.  Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. , 1994, The Journal of biological chemistry.

[135]  W. May,et al.  Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. , 1994, The Journal of biological chemistry.

[136]  T. Farrah,et al.  Molecular cloning of a ligand for the flt3 flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells , 1993, Cell.

[137]  A. Kimchi,et al.  Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression , 1993, Molecular and cellular biology.

[138]  C. Adra,et al.  Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA. , 1993, The EMBO journal.

[139]  D. Morrison,et al.  Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase , 1993, Molecular and cellular biology.

[140]  K. Arai,et al.  Signal transduction by the high‐affinity GM‐CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. , 1993, The EMBO journal.

[141]  G. Krystal,et al.  Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. , 1993, Blood.

[142]  G. Krystal,et al.  Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. , 1993, The Journal of biological chemistry.

[143]  S. Nagata,et al.  Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor , 1993, Cell.

[144]  J. Thompson,et al.  The PH domain: a common piece in the structural patchwork of signalling proteins. , 1993, Trends in biochemical sciences.

[145]  D. Morgan,et al.  Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae , 1993, Molecular and cellular biology.

[146]  A. Kimchi,et al.  Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells , 1993, Molecular and cellular biology.

[147]  W. Farrar,et al.  Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck. , 1993, The Biochemical journal.

[148]  B. Howell,et al.  Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine. , 1993, The Journal of biological chemistry.

[149]  J. Schlessinger,et al.  How receptor tyrosine kinases activate Ras. , 1993, Trends in biochemical sciences.

[150]  R. Manfredini,et al.  Inhibition of c-fes expression by an antisense oligomer causes apoptosis of HL60 cells induced to granulocytic differentiation , 1993, The Journal of experimental medicine.

[151]  R. Glazer,et al.  Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713). , 1993, Oncogene.

[152]  O. Silvennoinen,et al.  JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin , 1993, Cell.

[153]  D. Beier,et al.  Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene , 1993, Cell.

[154]  G. Superti-Furga,et al.  Csk inhibition of c‐Src activity requires both the SH2 and SH3 domains of Src. , 1993, The EMBO journal.

[155]  S. Corey,et al.  Granulocyte macrophage‐colony stimulating factor stimulates both association and activation of phosphoinositide 3OH‐kinase and src‐related tyrosine kinase(s) in human myeloid derived cells. , 1993, The EMBO journal.

[156]  T. Yagi,et al.  Constitutive activation of Src family kinases in mouse embryos that lack Csk , 1993, Cell.

[157]  Philippe Soriano,et al.  Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice , 1993, Cell.

[158]  Y. Yazaki,et al.  Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells. , 1993, Blood.

[159]  J. Ihle,et al.  Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand , 1993, Molecular and cellular biology.

[160]  K. Siminovitch,et al.  Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene , 1993, Nature Genetics.

[161]  A. Altman,et al.  Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. , 1993, Science.

[162]  T. Taniguchi,et al.  The IL-2 IL-2 receptor system: A current overview , 1993, Cell.

[163]  K. Arai,et al.  c‐fps/fes protein‐tyrosine kinase is implicated in a signaling pathway triggered by granulocyte‐macrophage colony‐stimulating factor and interleukin‐3. , 1993, The EMBO journal.

[164]  A. Leutz,et al.  The NF‐M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. , 1993, The EMBO journal.

[165]  N. Copeland,et al.  Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit. , 1993, Oncogene.

[166]  M. Nakafuku,et al.  Function of Ras as a molecular switch in signal transduction. , 1992, The Journal of biological chemistry.

[167]  F. Collart,et al.  Protein kinase C beta gene expression is associated with susceptibility of human promyelocytic leukemia cells to phorbol ester-induced differentiation. , 1992, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[168]  John Calvin Reed,et al.  Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines. , 1992, Blood.

[169]  T. Graf,et al.  Chicken “erythroid” cells transformed by the Gag-Myb-Ets-encoding E26 leukemia virus are multipotent , 1992, Cell.

[170]  M. Barbacid,et al.  Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells , 1992, Science.

[171]  A. Ullrich,et al.  Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs , 1992, Nature.

[172]  M. Barbacid,et al.  Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates , 1992, Nature.

[173]  Y. Kaziro,et al.  Inhibition of interleukin 3 and granulocyte-macrophage colony-stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases. , 1992, The Journal of biological chemistry.

[174]  O. Witte,et al.  The BCR gene encodes a novel serine/threonine kinase activity within a single exon , 1991, Cell.

[175]  S. Nishikawa,et al.  Expression and function of c-kit in hemopoietic progenitor cells , 1991, The Journal of experimental medicine.

[176]  D. Pardoll,et al.  A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations , 1991, Cell.

[177]  R. Perlmutter,et al.  Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association , 1991, Science.

[178]  C. Hall,et al.  Bcr encodes a GTPase-activating protein for p21rac , 1991, Nature.

[179]  Jonathan A. Cooper,et al.  Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src , 1991, Nature.

[180]  M. Nakafuku,et al.  Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[181]  S. Orkin,et al.  Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 , 1991, Nature.

[182]  G. Cooper,et al.  Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells , 1990, Molecular and cellular biology.

[183]  S. Nishikawa,et al.  The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene , 1990, Nature.

[184]  D. Lowy,et al.  A highly efficient retroviral vector allows detection of the transforming activity of the human c-fps/fes proto-oncogene , 1989, Journal of virology.

[185]  T. Pawson,et al.  The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family , 1989, Molecular and cellular biology.

[186]  M. Barbacid,et al.  vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. , 1989, The EMBO journal.

[187]  G. Yu,et al.  K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation. , 1989, The Journal of biological chemistry.

[188]  L. Shultz,et al.  Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev). , 1989, Experimental hematology.

[189]  G. Yu,et al.  Identification of the differentiation-associated p93 tyrosine protein kinase of HL-60 leukemia cells as the product of the human c-fes locus and its expression in myelomonocytic cells. , 1988, The Journal of biological chemistry.

[190]  T. Pawson,et al.  The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity , 1988, Molecular and cellular biology.

[191]  D. K. Ways,et al.  Dissimilar effects of phorbol ester and diacylglycerol derivative on protein kinase activity in the monoblastoid U937 cell. , 1987, Cancer research.

[192]  R. I. Glazer,et al.  Synergistic effect of retinoic acid and calcium ionophore A23187 on differentiation, c-myc expression, and membrane tyrosine kinase activity in human promyelocytic leukemia cell line HL-60. , 1987, Molecular pharmacology.

[193]  R. I. Glazer,et al.  Appearance of membrane-bound tyrosine kinase during differentiation of HL-60 leukemia cells by immune interferon and tumor necrosis factor. , 1986, Biochemical and biophysical research communications.

[194]  E. Huberman,et al.  Translocation of protein kinase C in human leukemia cells susceptible or resistant to differentiation induced by phorbol 12-myristate 13-acetate. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[195]  Mark R. Smith,et al.  Requirement for c-ras proteins during viral oncogene transformation , 1986, Nature.

[196]  H. Hanafusa,et al.  Antipeptide antiserum identifies a widely distributed cellular tyrosine kinase related to but distinct from the c-fps/fes-encoded protein , 1986, Molecular and cellular biology.

[197]  J. Samarut,et al.  Chicken myeloid stem cells infected by retroviruses carrying the v-fps oncogene do not require exogenous growth factors to differentiate in vitro , 1986, Cell.

[198]  A. V. D. van den Ouweland,et al.  The structure of the human c‐fes/fps proto‐oncogene. , 1985, The EMBO journal.

[199]  T. Pawson,et al.  Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein , 1985, Molecular and cellular biology.

[200]  Charles J. Sherr,et al.  The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1 , 1985, Cell.

[201]  J. Gabrilove,et al.  Specific expression of the human cellular fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[202]  Mark R. Smith,et al.  Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells , 1985, Nature.

[203]  A. Ullrich,et al.  Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences , 1984, Nature.

[204]  M. Shibuya,et al.  Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses , 1982, Cell.

[205]  F. Galibert,et al.  Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes , 1982, Cell.

[206]  H. Koeffler,et al.  Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation. , 1981, Cancer research.

[207]  W. S. Hayward,et al.  Characterization of the transforming gene of Fujinami sarcoma virus. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[208]  S. Collins,et al.  Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[209]  C. Damsky,et al.  Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[210]  E. Huberman,et al.  Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[211]  S. Collins,et al.  Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[212]  S. Collins,et al.  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture , 1977, Nature.

[213]  C. Franceschi,et al.  Antisense inhibition of c-fes proto-oncogene blocks PMA-induced macrophage differentiation in HL60 and in FDC-P1/MAC-11 cells. , 1997, Blood.

[214]  N. Tapon,et al.  Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. , 1997, Current opinion in cell biology.

[215]  N. Tanaka,et al.  The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. , 1996, Annual review of immunology.

[216]  A. D. de Vos,et al.  Hematopoietic receptor complexes. , 1996, Annual review of biochemistry.

[217]  J. Maher,et al.  Mutant ras promotes haemopoietic cell proliferation or differentiation in a cell-specific manner. , 1996, Leukemia.

[218]  C. Marshall.  Ras effectors. , 1996, Current opinion in cell biology.

[219]  O. Silvennoinen,et al.  Signaling through the hematopoietic cytokine receptors. , 1995, Annual review of immunology.

[220]  O. Miura,et al.  Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites. , 1995, Blood.

[221]  S. Orkin,et al.  Hematopoiesis: how does it happen? , 1995, Current opinion in cell biology.

[222]  I. Weissman,et al.  The biology of hematopoietic stem cells. , 1995, Annual review of cell and developmental biology.

[223]  S. Rhee,et al.  Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes. , 1995, Current opinion in cell biology.

[224]  J. Darnell,et al.  Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. , 1995, Annual review of biochemistry.

[225]  J. Bolen.  Protein tyrosine kinases in the initiation of antigen receptor signaling. , 1995, Current opinion in immunology.

[226]  D. Kufe,et al.  All-trans retinoic acid reverses phorbol ester resistance in a human myeloid leukemia cell line. , 1994, Blood.

[227]  L. Luzzatto,et al.  Retroviral-mediated gene transfer of a mutant H-ras gene into normal human bone marrow alters myeloid cell proliferation and differentiation. , 1994, Experimental hematology.

[228]  D. Lowy,et al.  Function and regulation of ras. , 1993, Annual review of biochemistry.

[229]  W. Fantl,et al.  Signalling by receptor tyrosine kinases. , 1993, Annual review of biochemistry.

[230]  J. Schlessinger,et al.  Signaling by Receptor Tyrosine Kinases , 1993 .

[231]  A. Kimchi,et al.  Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.