Molecular mechanism of immunoglobulin class switch recombination.

[1]  T. Honjo,et al.  Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells* , 1999, The Journal of Biological Chemistry.

[2]  T. Misteli,et al.  RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. , 1999, Molecular cell.

[3]  Andreas Radbruch,et al.  An extrachromosomal switch recombination substrate reveals kinetics and substrate requirements of switch recombination in primary murine B cells. , 1999, International immunology.

[4]  Andreas Radbruch,et al.  Processing of Switch Transcripts Is Required for Targeting of Antibody Class Switch Recombination , 1998, The Journal of experimental medicine.

[5]  T. Honjo,et al.  Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. , 1998, Immunity.

[6]  F. Alt,et al.  Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching , 1998, The Journal of experimental medicine.

[7]  Heikyung Suh,et al.  Ku80 is required for immunoglobulin isotype switching , 1998, The EMBO journal.

[8]  Tasuku Honjo,et al.  Frequent but biased class switch recombination in the Sμ flanking regions , 1998, Current Biology.

[9]  A. Shanmugam,et al.  Analysis of immunoglobulin Sgamma3 recombination breakpoints by PCR: implications for the mechanism of isotype switching. , 1997, Nucleic acids research.

[10]  K. Marcu,et al.  Antibody class switch recombinase activity is B cell stage specific and functions stochastically in the absence of 'targeted accessibility' control. , 1997, International immunology.

[11]  C. Snapper,et al.  The immunoglobulin class switch: beyond "accessibility". , 1997, Immunity.

[12]  N. Maizels,et al.  Developmental specificity of immunoglobulin heavy chain switch region recombination activities. , 1997, Molecular immunology.

[13]  A. Rolink,et al.  The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching , 1996 .

[14]  T. Honjo,et al.  High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells. , 1996, International immunology.

[15]  P. Jeggo,et al.  Menage á trois: Double strand break repair, V(D)J recombination and DNA‐PK , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[16]  M. Lieber,et al.  Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Andreas Radbruch,et al.  Switch transcripts in immunoglobulin class switching. , 1995, Science.

[18]  R. Kumar,et al.  Extrachromosomal eukaryotic DNA substrates for switch recombination: analysis of isotype and cell specificity. , 1994, DNA and cell biology.

[19]  F. Alt,et al.  S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. , 1994, The EMBO journal.

[20]  K. Rajewsky,et al.  Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting , 1993, Cell.

[21]  F. Alt,et al.  Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[22]  K. Rajewsky,et al.  Shutdown of class switch recombination by deletion of a switch region control element , 1993, Science.

[23]  G. Hertz,et al.  DNA sequences at immunoglobulin switch region recombination sites. , 1993, Nucleic acids research.

[24]  N. Maizels,et al.  Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[25]  L. Brunton,et al.  Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. , 1991, Molecular and cellular biology.

[26]  H. Sakano,et al.  Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching , 1990, Cell.

[27]  T. Honjo,et al.  Circular DNA is excised by immunoglobulin class switch recombination , 1990, Cell.

[28]  M. Wabl,et al.  Circular DNA is a product of the immunoglobulin class switch rearrangement , 1990, Nature.

[29]  J. Stavnezer,et al.  Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch , 1989, Molecular and cellular biology.

[30]  J. Stavnezer,et al.  Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[31]  A. Whitmore,et al.  Ig isotype switching in B lymphocytes. Isolation and characterization of clonal variants of the murine Ly-1+ B cell lymphoma, CH12, expressing isotypes other than IgM. , 1988, Journal of immunology.

[32]  F. Alt,et al.  Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching , 1988, Cell.

[33]  F. Alt,et al.  Secondary genomic rearrangement events in pre‐B cells: VHDJH replacement by a LINE‐1 sequence and directed class switching. , 1986, The EMBO journal.

[34]  T. Honjo,et al.  Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter , 1986, Nature.

[35]  S. Sirlin,et al.  Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. , 1986, The EMBO journal.

[36]  T. Honjo,et al.  Immunoglobulin class switching , 1984, Cell.

[37]  T. Honjo,et al.  Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison. , 1982, The Journal of biological chemistry.

[38]  T. Honjo,et al.  Organization of the constant-region gene family of the mouse immunoglobulin heavy chain , 1982, Cell.

[39]  E. Puré,et al.  T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells , 1982, The Journal of experimental medicine.

[40]  Mark M. Davis,et al.  DNA sequences mediating class switching in alpha-immunoglobulins. , 1980, Science.

[41]  C. Milstein,et al.  An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing , 1980, Nature.

[42]  S. Cory,et al.  Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression , 1980, Nature.

[43]  S. Tonegawa,et al.  Exon shuffling generates an immunoglobulin heavy chain gene. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[44]  T. Rabbitts,et al.  The role of gene deletion in the immunoglobulin heavy chain switch , 1980, Nature.

[45]  T. Honjo,et al.  Organization of immunoglobulin heavy chain genes and allelic deletion model. , 1978, Proceedings of the National Academy of Sciences of the United States of America.