Image registration for microwave tomography of the breast using priors from non-simultaneous previous magnetic resonance images

Microwave tomography (MT), a novel imaging modality in which the body is probed non-invasively using non-ionizing high-frequency radio-frequency waves, has shown promise for breast cancer screening and more recently for the monitoring of chemotherapy treatment. As an inherently low-resolution modality, it has been shown that prior structural information from another imaging modality, such as magnetic resonance imaging (MRI), can be used to improve the spatial resolution and quantitative accuracy of MT. In this paper, we show the results of a single-patient trial in which we co-register a non-simultaneous prior MRI with MT data acquired in a fluid bath. For the purposes of registration evaluation, two MRI images were acquired, one in air and one in fluid, and the registration errors were evaluated for manually selected internal image features, for a number of image registration algorithms.

[1]  Shireen D. Geimer,et al.  Microwave image reconstruction from 3-D fields coupled to 2-D parameter estimation , 2004, IEEE Transactions on Medical Imaging.

[2]  Jürgen Weese,et al.  Landmark-based elastic registration using approximating thin-plate splines , 2001, IEEE Transactions on Medical Imaging.

[3]  Paul M. Meaney,et al.  Enhancing breast tumor detection with near-field imaging , 2002 .

[4]  Keith D Paulsen,et al.  Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience , 2012, Breast Cancer Research.

[5]  Jean-Philippe Thiran,et al.  Affine Registration with Feature Space Mutual Information , 2001, MICCAI.

[6]  Sven Kabus,et al.  B-spline registration of 3D images with Levenberg-Marquardt optimization , 2004, SPIE Medical Imaging.

[7]  Paul M. Meaney,et al.  A clinical prototype for active microwave imaging of the breast , 2000 .

[8]  Keith D Paulsen,et al.  Surface scanning through a cylindrical tank of coupling fluid for clinical microwave breast imaging exams. , 2012, Medical physics.

[9]  Ron Kikinis,et al.  3D Slicer , 2012, 2004 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro (IEEE Cat No. 04EX821).

[10]  Luis Ibáñez,et al.  The ITK Software Guide , 2005 .

[11]  Amir H. Golnabi,et al.  Tomographic Microwave Imaging With Incorporated Prior Spatial Information , 2013, IEEE Transactions on Microwave Theory and Techniques.

[12]  Elise C. Fear,et al.  Microwave detection of breast cancer , 2000 .

[13]  K. Paulsen,et al.  IMPORTANCE OF USING A REDUCED CONTRAST COUPLING MEDIUM IN 2D MICROWAVE BREAST IMAGING , 2003 .