INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES (Int. J. of Pharm. Life Sci.) Hematological alterations induced by Sodium arsenate toxicity in Albino mice

Arsenic is one of the most dangerous occupational and environmental toxins. Arsenic (As) is a toxic and carcinogenic metalloid. For the general population, arsenic In drinking water is the main exposure source, and more harmful than arsenic in food, because the bioavailability (actual amount absorbed into the bloodstream) of arsenic from water is greater than that from grains or vegetable. Arsenic exists in the trivalent and pentavalent forms and is widely distributed in nature. The drastic adverse changes in the various hematological parameters were observed in treated mice when compared control animals. Haematological parameters are used as sensitive indicators of toxicity due to different pollutant. First group exposed to tap water maintained as control where as second and third groups were treated with different doses of Sodium arsenate. Blood samples were collected after 7 days and 14 days. The lymphocytes were severely damaged by arsenic toxicity. White Blood Cells (WBCs), Red Blood Cells (RBCs) and hemoglobin level in control groups were in normal range whereas level were significantly decreased with the increase dose of arsenic in the respective treatmental groups. The data was analyzed statistically and was found that significant was found among the group (p < 0.05).

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