Phylogeny of ion channels: clues to structure and function.

Voltage-gated ion channels are responsible for the electrical activity in a variety of cell types in modern-day animals. However, they represent the result of many millions of years of evolution of a family of ion channel proteins that are also found in prokaryotes and diverse eukaryotes, and probably exist in all life forms. This review traces the evolution of ion channels, with particular emphasis on the factors and evolutionary pathways that may have given rise to voltage-gated potassium (K+), calcium (Ca2+), and sodium (Na+) channels. The review also highlights the utility of comparing phylogenetically distinct versions of the same protein as a means to better understand the structure and function of proteins.

[1]  G. Matsumoto,et al.  Primary structure of squid sodium channel deduced from the complementary DNA sequence. , 1992, Biochemical and biophysical research communications.

[2]  R. Tsien,et al.  Three types of neuronal calcium channel with different calcium agonist sensitivity , 1985, Nature.

[3]  B. Ganetzky,et al.  Molecular analysis of the para locus, a sodium channel gene in Drosophila , 1989, Cell.

[4]  I. Levitan,et al.  It Is Calmodulin After All! Mediator of the Calcium Modulation of Multiple Ion Channels , 1999, Neuron.

[5]  Christopher Miller,et al.  Ion channels: doing hard chemistry with hard ions. , 2000, Current opinion in chemical biology.

[6]  J. Tytgat,et al.  Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs , 1992, Neuron.

[7]  H. Breer,et al.  Identification of a cyclic nucleotide- and voltage-activated ion channel from insect antennae. , 1999, Insect biochemistry and molecular biology.

[8]  P. Anderson.  Properties and Pharmacology of a TTX-insensitive Na+ Current in Neurones of the Jellyfish Cyanea Capillata , 1987 .

[9]  B. Hille.  Ionic channels of excitable membranes , 2001 .

[10]  Richard J. Miller.  A tale of two toxins , 1993, Current Biology.

[11]  Y. Jan,et al.  Potassium channels and their evolving gates , 1994, Nature.

[12]  K. Chandy,et al.  Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. , 1993, Molecular biology and evolution.

[13]  P. A. Anderson,et al.  The molecular biology of invertebrate voltage-gated Ca(2+) channels. , 2000, The Journal of experimental biology.

[14]  R. Tsien,et al.  Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels , 1993, Nature.

[15]  Gail Mandel,et al.  Nomenclature of Voltage-Gated Sodium Channels , 2000, Neuron.

[16]  J. Spafford,et al.  Genomic organization of a voltage-gated Na+ channel in a hydrozoan jellyfish: insights into the evolution of voltage-gated Na+ channel genes. , 1999, Receptors & channels.

[17]  L. Salkoff,et al.  A family of putative potassium channel genes in Drosophila. , 1989, Science.

[18]  A. Karschin,et al.  Evolutionary link between prokaryotic and eukaryotic K+ channels. , 1998, The Journal of experimental biology.

[19]  W. Catterall,et al.  From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels , 2000, Neuron.

[20]  J. Rosenthal,et al.  Amino acid sequence of a putative sodium channel expressed in the giant axon of the squid Loligo opalescens. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M. Spira,et al.  Alterations of voltage-activated sodium current by a novel conotoxin from the venom of Conus gloriamaris. , 1995, Journal of neurophysiology.

[22]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[23]  Lawrence Salkoff,et al.  Shaker, Shal, Shab, and Shaw express independent K+ current systems , 1991, Neuron.

[24]  J. Littleton,et al.  Ion Channels and Synaptic Organization Analysis of the Drosophila Genome , 2000, Neuron.

[25]  J. Wood,et al.  Voltage-gated sodium channels. , 2001, Current opinion in pharmacology.

[26]  M. Gopalakrishnan,et al.  Glutamate substitution in repeat IV alters divalent and monovalent cation permeation in the heart Ca2+ channel. , 1995, Biophysical journal.

[27]  K. Campbell,et al.  Identification of critical amino acids involved in α 1‐β interaction in voltage‐dependent Ca2+ channels , 1996 .

[28]  L. Salkoff,et al.  A multigene family of novel K+ channels from Paramecium tetraurelia. , 1995, Receptors & channels.

[29]  B. Rudy,et al.  Molecular Diversity of K+ Channels , 1999, Annals of the New York Academy of Sciences.

[30]  M. Meisler,et al.  Evolution and diversity of mammalian sodium channel genes. , 1999, Genomics.

[31]  U. Kaupp,et al.  Molecular identification of a hyperpolarization-activated channel in sea urchin sperm , 1998, Nature.

[32]  Jung-Ha Lee,et al.  Cloning of a novel four repeat protein related to voltage‐gated sodium and calcium channels , 1999, FEBS letters.

[33]  H. Guy,et al.  Evolutionary relationship between K(+) channels and symporters. , 1999, Biophysical journal.

[34]  L. Salkoff,et al.  Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila. , 1987, Science.

[35]  A. Bahinski,et al.  Differential contribution by conserved glutamate residues to an ion‐selectivity site in the L‐type Ca2+ channel pore , 1993, FEBS letters.

[36]  R. Greenberg,et al.  Cloning and Functional Expression of a Voltage-gated Calcium Channel α1 Subunit from Jellyfish* , 1998, The Journal of Biological Chemistry.

[37]  Q. Bone,et al.  SODIUM-CALCIUM ACTION POTENTIAL ASSOCIATED WITH CONTRACTION IN THE HELIOZOAN ACTINOCORYNE CONTRACTILIS , 1986 .

[38]  H. Glossmann,et al.  Cloning and functional expression of a neuronal calcium channel beta subunit from house fly (Musca domestica). , 1994, The Journal of biological chemistry.

[39]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[40]  L. Salkoff,et al.  Multiple Shaker potassium channels in a primitive metazoan , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[41]  L. Salkoff,et al.  Surfing the DNA databases for K+ channels nets yet more diversity , 1995, Neuron.

[42]  R. Greenberg,et al.  Calcium channel β subunits differentially modulate recovery of the channel from inactivation , 2000, FEBS letters.

[43]  M. Adams,et al.  CALCIUM CHANNEL DIVERSITY AND NEUROTRANSMITTER RELEASE : THE OMEGA -CONOTOXINS AND OMEGA -AGATOXINS , 1994 .

[44]  M. Suzuki,et al.  Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. , 2000, Biochemical and biophysical research communications.

[45]  K. Campbell,et al.  Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit , 1994, Nature.