Phosphatase of regenerating liver-3 is regulated by signal transducer and activator of transcription 3 in acute myeloid leukemia.

[1]  G. Homanics,et al.  Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer , 2013, PloS one.

[2]  Q. Zeng,et al.  The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia , 2012, Molecular Cancer.

[3]  N. Varin‐Blank,et al.  A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line , 2012, Molecular Cancer.

[4]  R. Beekman,et al.  Retroviral Integration Mutagenesis in Mice and Comparative Analysis in Human AML Identify Reduced PTP4A3 Expression as a Prognostic Indicator , 2011, PloS one.

[5]  M. J. Ruiz,et al.  Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. , 2011, Blood.

[6]  J. Li,et al.  PRL-3, a Metastasis Associated Tyrosine Phosphatase, Is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy , 2011, PloS one.

[7]  W. Su,et al.  Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells , 2010, Molecular Cancer.

[8]  Q. Zeng,et al.  PRL‐3 phosphatase and cancer metastasis , 2010, Journal of cellular biochemistry.

[9]  Qiang Yu,et al.  The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. , 2010, Blood.

[10]  Jian-ming Li,et al.  Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer. , 2010, Journal of proteome research.

[11]  T. Zhu,et al.  STAT3alpha is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone. , 2010, Endocrinology.

[12]  Li Lin,et al.  A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells , 2010, Molecular Cancer.

[13]  J. Li,et al.  PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. , 2010, Cancer cell.

[14]  H. Malech,et al.  Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. , 2010, Experimental hematology.

[15]  Qiang Xu,et al.  An Anticancer Effect of Curcumin Mediated by Down-Regulating Phosphatase of Regenerating Liver-3 Expression on Highly Metastatic Melanoma Cells , 2009, Molecular Pharmacology.

[16]  C. Shou,et al.  PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling , 2009, Molecular Cancer.

[17]  H. Baumann,et al.  Targeting signal transducer and activator of transcription signaling pathway in leukemias. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  S. Semba,et al.  Down‐modulation of keratin 8 phosphorylation levels by PRL‐3 contributes to colorectal carcinoma progression , 2009, International journal of cancer.

[19]  X. Qiu,et al.  PRL‐3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up‐regulating the levels and activities of Rho‐A/C in lung cancer , 2009, Pathology.

[20]  B. Johansson,et al.  BRAF mutations are very rare in B- and T-cell pediatric acute lymphoblastic leukemias , 2008, Leukemia.

[21]  A. Giaccia,et al.  The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. , 2008, Molecular cell.

[22]  R. De Francesco,et al.  Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3. , 2008, Biochimica et biophysica acta.

[23]  C. Pallen,et al.  PRL PTPs: mediators and markers of cancer progression , 2008, Cancer and Metastasis Reviews.

[24]  F. Zhan,et al.  Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. , 2008, Blood.

[25]  G. Hostetter,et al.  Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells , 2008, Molecular Cancer Therapeutics.

[26]  K. Glaser,et al.  Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. , 2007, Blood.

[27]  R. Flavell,et al.  Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery , 2007, Laboratory Investigation.

[28]  Q. Zeng,et al.  PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. , 2007, Cancer research.

[29]  E. Udho,et al.  PRL3 Promotes Cell Invasion and Proliferation by Down-regulation of Csk Leading to Src Activation* , 2007, Journal of Biological Chemistry.

[30]  G. Mills,et al.  Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. , 2007, Cancer research.

[31]  N. Reich,et al.  Tracking STAT nuclear traffic , 2006, Nature Reviews Immunology.

[32]  C. Shou,et al.  Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3. , 2006, Biochemical and biophysical research communications.

[33]  A. Cox,et al.  PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. , 2006, Cancer research.

[34]  D. V. Von Hoff,et al.  PRL phosphatases as potential molecular targets in cancer , 2005, Molecular Cancer Therapeutics.

[35]  Q. Zeng,et al.  Generation of PRL-3- and PRL-1-Specific Monoclonal Antibodies as Potential Diagnostic Markers for Cancer Metastases , 2005, Clinical Cancer Research.

[36]  Joanna M. Sasin,et al.  Protein Tyrosine Phosphatases in the Human Genome , 2004, Cell.

[37]  Hua Yu,et al.  The STATs of cancer — new molecular targets come of age , 2004, Nature Reviews Cancer.

[38]  D. Frank,et al.  The role of STATs in apoptosis. , 2002, Current molecular medicine.

[39]  J. Bromberg.  Stat proteins and oncogenesis. , 2002, The Journal of clinical investigation.

[40]  Michael A. Choti,et al.  A Phosphatase Associated with Metastasis of Colorectal Cancer , 2001, Science.

[41]  W. Hiddemann,et al.  Constitutive activation of STAT transcription factors in acute myelogenous leukemia , 2001, European journal of haematology.

[42]  R. Arceci,et al.  Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells. , 2001, Blood.

[43]  R. Taub,et al.  ATF-7, a Novel bZIP Protein, Interacts with the PRL-1 Protein-tyrosine Phosphatase* , 2001, The Journal of Biological Chemistry.

[44]  B. Neel,et al.  Combinatorial control of the specificity of protein tyrosine phosphatases. , 2001, Current opinion in cell biology.

[45]  E. Vellenga,et al.  Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. , 2000, Blood.

[46]  P. Coffer,et al.  The role of STATs in myeloid differentiation and leukemia , 2000, Oncogene.

[47]  Thomas S. Lin,et al.  STAT signaling in the pathogenesis and treatment of leukemias , 2000, Oncogene.

[48]  F. Xy.  From PTK-STAT signaling to caspase expression and apoptosis induction. , 1999 .

[49]  W. Hiddemann,et al.  Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia. , 1999, Experimental hematology.

[50]  S. Akira,et al.  IL-6-regulated transcription factors. , 1997, The international journal of biochemistry & cell biology.

[51]  B. Groner,et al.  STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients , 1996 .

[52]  J. Darnell,et al.  A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. , 1995, Genes & development.

[53]  J. Darnell,et al.  Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. , 1994, Science.

[54]  Z. Xia,et al.  Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. , 2002, Blood.

[55]  A. Yoshimura,et al.  The Jak-Stat pathway in normal and perturbed hematopoiesis. , 2000, Blood.