Review of theoretical passive drug absorption models: historical background, recent developments and limitations.

[1]  G. Grassy,et al.  Glossary of terms used in computational drug design (IUPAC Recommendations 1997) , 1997 .

[2]  P. Borst,et al.  Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. , 1995, The Journal of clinical investigation.

[3]  Michael H. Abraham,et al.  The Factors that Influence Skin Penetration of Solutes * , 1995 .

[4]  S. Balaz Quantitative structure-time-activity relationships for single and continuous dose , 1994 .

[5]  A. Leo CALCULATING LOG POCT FROM STRUCTURES , 1993 .

[6]  R. Guy,et al.  The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes. , 1993, Pharmaceutical research.

[7]  W. Rubas,et al.  Structural Elements Which Govern the Resistance of Intestinal Tissues to Compound Transport , 1993 .

[8]  M. Kansy,et al.  Hydrogen-Bonding Capacity and Brain Penetration , 1992, Chimia (Basel).

[9]  Bernard Testa,et al.  Polar intermolecular interactions encoded in partition coefficients: an indirect estimation of hydrogen-bond parameters of polyfunctional solutes , 1992 .

[10]  P. Artursson,et al.  Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. , 1991, Biochemical and biophysical research communications.

[11]  P. Artursson Cell cultures as models for drug absorption across the intestinal mucosa. , 1991, Critical reviews in therapeutic drug carrier systems.

[12]  Sietsema Wk,et al.  The absolute oral bioavailability of selected drugs , 1989 .

[13]  D Mackay,et al.  A novel method for measuring membrane-water partition coefficients of hydrophobic organic chemicals: comparison with 1-octanol-water partitioning. , 1988, Journal of Pharmacy and Science.

[14]  R Griffiths,et al.  Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists. , 1988, Journal of medicinal chemistry.

[15]  K. Audus,et al.  Relationship of octanol/buffer and octanol/water partition coefficients to transcellular diffusion across brain microvessel endothelial cell monolayers , 1986 .

[16]  J. K. Seydel,et al.  QSAR and strategies in the design of bioactive compounds , 1985 .

[17]  W. Higuchi,et al.  Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and humans , 1983 .

[18]  Klaus-Jürgen Schaper Absorption of Ionizable Drugs: Nonlinear Dependence on log P, pKa and pH ‐ Quantitative Relationships , 1982 .

[19]  Y. Martin,et al.  A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry. , 1981, Journal of medicinal chemistry.

[20]  C S Patlak,et al.  Methods for Quantifying the transport of drugs across brain barrier systems. , 1981, Pharmacology & therapeutics.

[21]  P. Seiler,et al.  Steric and lipophobic components of the hydrophobic fragmental constant. , 1981, Arzneimittel-Forschung.

[22]  K J Schaper,et al.  Quantitative structure-pharmacokinetic relationships and drug design. , 1981, Pharmacology & therapeutics.

[23]  W. Pardridge,et al.  Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone. , 1979, The Journal of clinical investigation.

[24]  H Kubinyi,et al.  Lipophilicity and drug activity. , 1979, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[25]  T. Fujita,et al.  Hydrogen-bonding parameter and its significance in quantitative structure--activity studies. , 1977, Journal of medicinal chemistry.

[26]  S. M. Howard,et al.  Use of distribution coefficients in quantitative structure-activity relationships. , 1977, Journal of medicinal chemistry.

[27]  Y. Martin,et al.  Theoretical model-based equations for the linear free energy relationships of the biological activity of ionizable substances. 1. Equilibrium-controlled potency. , 1976, Journal of medicinal chemistry.

[28]  C. Hansch,et al.  Selection of a reference partitioning system for drug design work. , 1975, Journal of pharmaceutical sciences.

[29]  M. Lucas,et al.  Acidification in the rat proximal jejunum. , 1975, The Journal of physiology.

[30]  W H Oldendorf,et al.  Lipid Solubility and Drug Penetration of the Blood Brain Barrier , 1974, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[31]  S. Yalkowsky,et al.  Effects of alkyl chain length on biological activity: alkyl p-aminobenzoate-induced narcosis in goldfish. , 1974, Journal of pharmaceutical sciences.

[32]  S. Yalkowsky,et al.  Mass transport phenomena and models: theoretical concepts. , 1974, Journal of pharmaceutical sciences.

[33]  J. Bridges,et al.  A re-evaluation of the importance of partition coefficients in the gastrointestinal absorption of anutrients. , 1974, The Journal of pharmacology and experimental therapeutics.

[34]  Blair Ja,et al.  Acid microclimate in intestinal absorption. , 1974 .

[35]  S. Yalkowsky,et al.  Transport of alkyl homologs across synthetic and biological membranes: a new model for chain length-activity relationships. , 1973, Journal of pharmaceutical sciences.

[36]  S. Yalkowsky,et al.  Correlation and prediction of mass transport across membranes. I. Influence of alkyl chain length on flux-determining properties of barrier and diffusant. , 1972, Journal of pharmaceutical sciences.

[37]  W. Higuchi,et al.  Theoretical model studies of drug absorption and transport in the GI tract. 3. , 1972, Journal of pharmaceutical sciences.

[38]  W. R. Lieb,et al.  The Molecular Basis of Simple Diffusion within Biological Membranes , 1972 .

[39]  W. Higuchi,et al.  In vitro model for transport of solutes in three-phase system. I. Theoretical principles. , 1972, Journal of pharmaceutical sciences.

[40]  A. Leo,et al.  Partition coefficients and their uses , 1971 .

[41]  L. Dittert,et al.  Drug absorption IV: influence of pH on absorption kinetics of weakly acidic drugs. , 1971, Journal of pharmaceutical sciences.

[42]  W. Higuchi,et al.  Theoretical model studies of drug absorption and transport in the gastrointestinal tract.i. , 1970, Journal of pharmaceutical sciences.

[43]  C. Hansch Quantitative approach to biochemical structure-activity relationships , 1969 .

[44]  T. Arita,et al.  Absorption and excretion of drugs. 33. The correlation between the absorption of barbituric acid derivatives from the rat small intestine and their binding to the mucosa. , 1969, Chemical & pharmaceutical bulletin.

[45]  A. Moffat,et al.  The influence of alkyl substitution in acids on their performance in the buccal absorption test , 1968, The Journal of pharmacy and pharmacology.

[46]  T. Arita,et al.  Absorption and excretion of drugs. XXXII. Absorption of barbituric acid derivatives from rat small intestine. , 1967, Chemical & pharmaceutical bulletin.

[47]  W. Higuchi,et al.  Diffusional model for transport rate studies across membranes. , 1967, Journal of pharmaceutical sciences.

[48]  R. Scheuplein Analysis of permeability data for the case of parallel diffusion pathways. , 1966, Biophysical journal.

[49]  T. Arita,et al.  Absorption and excretion of drugs. XXV. On the mechanism of rectal absorption of sulfonamides. , 1965, Chemical & pharmaceutical bulletin.

[50]  C. Hansch,et al.  A NEW SUBSTITUENT CONSTANT, PI, DERIVED FROM PARTITION COEFFICIENTS , 1964 .

[51]  J. V. Swintosky,et al.  DRUG PARTITIONING. II. IN VITRO MODEL FOR DRUG ABSORPTION. , 1964, Journal of pharmaceutical sciences.

[52]  T. Arita,et al.  ABSORPTION AND EXCRETION OF DRUGS. XIX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (1). ABSORPTION FROM RAT STOMACH. , 1964, Chemical & pharmaceutical bulletin.

[53]  T. Arita,et al.  ABSORPTION AND EXCRETION OF DRUGS. XX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (2). ABSORPTION FROM RAT SMALL INTESTINE. , 1964, Chemical & pharmaceutical bulletin.

[54]  H. Nogami,et al.  Studies on Absorption and Excretion of Drugs. II. Kinetics of Penetration of Basic Drug, Aminopyrine, through the Intestinal Barrier in vitro. , 1962 .

[55]  J. Schulman,et al.  MECHANISM OF THE SELECTIVE FLUX OF SALTS AND WATER MIGRATION THROUGH NON-AQUEOUS LIQUID MEMBRANES , 1961 .

[56]  H. Nogami,et al.  Studies on Absorption and Excretion of Drugs. I. Kinetics of Penetration of Acidic Drug, Salicylic Acid, through the Intestinal Barrier in vitro. , 1961 .

[57]  B. Brodie,et al.  On the mechanism of intestinal absorption of drugs. , 1959, The Journal of pharmacology and experimental therapeutics.

[58]  B. Brodie,et al.  Absorption of drugs from the rat small intestine. , 1958, The Journal of pharmacology and experimental therapeutics.

[59]  B. Brodie,et al.  The gastric secretion of drugs: a pH partition hypothesis. , 1957, The Journal of pharmacology and experimental therapeutics.

[60]  E. M. Renkin,et al.  FILTRATION, DIFFUSION, AND MOLECULAR SIEVING THROUGH POROUS CELLULOSE MEMBRANES , 1954, The Journal of general physiology.

[61]  R. Collander,et al.  The Partition of Organic Compounds Between Higher Alcohols and Water. , 1951 .

[62]  R. Collander,et al.  The Distribution of Organic Compounds Between iso-Butanol and Water. , 1950 .

[63]  W. Nernst,et al.  Theorie der Reaktionsgeschwindigkeit in heterogenen Systemen , 1904 .

[64]  Erich Brunner,et al.  Reaktionsgeschwindigkeit in heterogenen Systemen , 1904 .