Multi-scale convolutional neural networks for segmentation of pulmonary structures in computed tomography

Computed tomography (CT) is routinely used for diagnosing lung disease and developing treatment plans using images of intricate lung structure with submillimeter resolution. Automated segmentation of anatomical structures in such images is important to enable efficient processing in clinical and research settings. Convolution neural networks (ConvNets) are largely successful at performing image segmentation with the ability to learn discriminative abstract features that yield generalizable predictions. However, constraints in hardware memory do not allow deep networks to be trained with high-resolution volumetric CT images. Restricted by memory constraints, current applications of ConvNets on volumetric medical images use a subset of the full image; limiting the capacity of the network to learn informative global patterns. Local patterns, such as edges, are necessary for precise boundary localization, however, they suffer from low specificity. Global information can disambiguate structures that are locally similar. The central thesis of this doctoral work is that both local and global information is important for segmentation of anatomical structures in medical images. A novel multi-scale ConvNet is proposed that divides the learning task across multiple networks; each network learns features over different ranges of scales. It is hypothesized that multi-scale ConvNets will lead to improved segmentation performance, as no compromise needs to be made between image resolution, image extent, and network depth. Three multi-scale models were designed to specifically target segmentation of three pulmonary