IncreasedMelanoma Risk in Individuals With Papillary Thyroid Carcinoma

DESIGN, SETTING, AND PARTICIPANTS Retrospective review using the Utah Population Database (which is linked to medical records and the Utah Cancer Registry from 1966 to 2011) and tissue analysis in a tertiary care facility. Included were 4460 patients diagnosed with PTC and 14 569 with CM in Utah between 1966 and 2011 and their firstthrough fifth-degree relatives and spouses. These were compared at a 5:1 ratio with matched, population-based controls.

[1]  M. Okano,et al.  Cohort Study , 2020, Definitions.

[2]  Ken R. Smith,et al.  Familial risk of childhood cancer and tumors in the li‐fraumeni spectrum in the utah population database: Implications for genetic evaluation in pediatric practice , 2013, International journal of cancer.

[3]  Ahmedin Jemal,et al.  Cancers with increasing incidence trends in the United States: 1999 through 2008 , 2012, CA: a cancer journal for clinicians.

[4]  A. Abdel‐Mageed,et al.  BRAF mutation in papillary thyroid carcinoma. , 2012, International journal of clinical and experimental medicine.

[5]  Marc S. Williams,et al.  Inflammatory bowel disease aggregation in Utah kindreds , 2011, Inflammatory bowel diseases.

[6]  Li-E. Wang,et al.  Clinical Correlates of NRAS and BRAF Mutations in Primary Human Melanoma , 2010, Clinical Cancer Research.

[7]  E. Bonora,et al.  Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies , 2010, Journal of oncology.

[8]  E. Erdei,et al.  Melanoma epidemiology and public health. , 2009, Dermatologic clinics.

[9]  Hensin Tsao,et al.  Melanoma and genetics. , 2009, Clinics in dermatology.

[10]  Ju-Han Lee,et al.  Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid , 2007, Cancer.

[11]  T. Fahey.  Increasing Incidence of Thyroid Cancer in the United States, 1973–2002 , 2007 .

[12]  J. Lundeberg,et al.  NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing , 2006, Melanoma research.

[13]  Louise Davies,et al.  Increasing incidence of thyroid cancer in the United States, 1973-2002. , 2006, JAMA.

[14]  G. Daniels,et al.  Elevation of thyroid cancer risk among cutaneous melanoma survivors , 2006, International journal of cancer.

[15]  P. Ladenson,et al.  BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. , 2005, The Journal of clinical endocrinology and metabolism.

[16]  R. Kerber,et al.  A cohort study of cancer risk in relation to family histories of cancer in the Utah population database , 2005, Cancer.

[17]  P. Hall,et al.  Second primary malignancies in thyroid cancer patients , 2003, British Journal of Cancer.

[18]  P. Gattuso,et al.  Genomic DNA Extraction and PCR Amplification of Exon 15 of the BRAF Gene and Exons 1 and 2 of the NRAS Gene , 2003 .

[19]  C. Pritchard,et al.  Raf proteins and cancer: B-Raf is identified as a mutational target. , 2003, Biochimica et biophysica acta.

[20]  Yuri E Nikiforov,et al.  High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. , 2003, Cancer research.

[21]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[22]  C. Peyssonnaux,et al.  The Raf/MEK/ERK pathway: new concepts of activation , 2001, Biology of the cell.

[23]  J. Hansson,et al.  Hereditary cutaneous melanoma. , 2000, Seminars in cancer biology.

[24]  R L Williams,et al.  A Note on Robust Variance Estimation for Cluster‐Correlated Data , 2000, Biometrics.

[25]  M. Khoury,et al.  Bias associated with study protocols in epidemiologic studies of disease familial aggregation. , 2000, American Journal of Epidemiology.

[26]  L. Akslen,et al.  Second malignancies in thyroid cancer patients: a population-based survey of 3658 cases from Norway. , 1992, European journal of cancer.

[27]  M. Tucker,et al.  Second cancer following cutaneous melanoma and cancers of the brain, thyroid, connective tissue, bone, and eye in Connecticut, 1935-82. , 1985, National Cancer Institute monograph.

[28]  Geraldine P. Mineau,et al.  A computerized family history data base system , 1979 .