Science fraud: from patchwork mouse to patchwork data

Summerlin pulled two white mice from the container. While they wriggled and squeaked in protest, he inspected the sites of the black skin grafts. Impulsively, Summerlin took his felttipped pen out of the breast pocket of his white coat and applied it briefly to the grafted patches on the two white animals. The ink made them look darker. Then he replaced the mice in the bin and strode out . . . From The Patchwork Mouse, an account of William T. Summerlin's 1974 false claim of skin transplantation without immunosuppression (1).

[1]  W. Summerlin.  Allogeneic transplantation of organ cultures of adult human skin. , 1973, Clinical immunology and immunopathology.

[2]  The Patchwork Mouse , 1976 .

[3]  The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. , 1995, Molecular and cellular biology.

[4]  F. Collins,et al.  Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein , 1996, Molecular and cellular biology.

[5]  E Marshall,et al.  Fraud Strikes Top Genome Lab , 1996, Science.

[6]  D. Peterson,et al.  The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. , 1998, Immunity.

[7]  D. Baltimore,et al.  Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. , 1999, Immunity.

[8]  J. Sudbø,et al.  DNA content as a prognostic marker in patients with oral leukoplakia. , 2001, The New England journal of medicine.

[9]  J. Sudbø,et al.  The influence of resection and aneuploidy on mortality in oral leukoplakia. , 2004, The New England journal of medicine.

[10]  J. Couzin.  Scientific misconduct. MIT terminates researcher over data fabrication. , 2005, Science.

[11]  Jennifer Couzin.  MIT Terminates Researcher Over Data Fabrication , 2005, Science.

[12]  G. Kolata.  Clone scandal: "a tragic turn" for science. , 2005, The New York times on the Web.

[13]  S. Paek,et al.  Patient-specific embryonic stem cells derived from human SCNT blastocysts. , 2005, Science.

[14]  B. Thiers.  Non-Steroidal Anti-inflammatory Drugs and the Risk of Oral Cancer: A Nested Case-Control Study , 2006 .

[15]  D. Kennedy.  Good News--and Bad , 2006, Science.