Rac 1 Protein Regulates Glycogen Phosphorylase Activation and Controls Interleukin ( IL )-2-dependent T Cell Proliferation

Onetsine Arrizabalaga, Hadriano M. Lacerda, Ana M. Zubiaga, and José L. Zugaza 3 From the Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, 48940 Leioa, Spain, Center for Cooperative Research CIC bioGUNE, 48160 Derio, Spain, Unit of Cancer Epidemiology, Department of Biomedical Sciences and Human Oncology, Università degli Studi di Torino, 10124 Torino, Italy, and IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain

[1]  Jin-San Zhang,et al.  GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration , 2011, Molecular biology of the cell.

[2]  Thamara K. Dayarathna,et al.  Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration. , 2011, Biochimica et biophysica acta.

[3]  Paola Chiarugi,et al.  Rac and Rho GTPases in cancer cell motility control , 2010, Cell Communication and Signaling.

[4]  J. Frost,et al.  Protein Phosphatase 2A Regulates Interleukin-2 Receptor Complex Formation and JAK3/STAT5 Activation* , 2009, The Journal of Biological Chemistry.

[5]  Ian R. Kelsall,et al.  Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo. , 2009, Cellular signalling.

[6]  Hans Janssen,et al.  The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. , 2009, Blood.

[7]  Stephan Huveneers,et al.  Adhesion signaling – crosstalk between integrins, Src and Rho , 2009, Journal of Cell Science.

[8]  B. Alarcón,et al.  Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling. , 2008, Cellular signalling.

[9]  T. Malek,et al.  The biology of interleukin-2. , 2008, Annual review of immunology.

[10]  Stephan Rosenkranz,et al.  Phosphatidylinositol 3-Kinase-dependent Membrane Recruitment of Rac-1 and p47phox Is Critical for α-Platelet-derived Growth Factor Receptor-induced Production of Reactive Oxygen Species* , 2008, Journal of Biological Chemistry.

[11]  Rodrigo Lopez,et al.  Clustal W and Clustal X version 2.0 , 2007, Bioinform..

[12]  S. Katzav,et al.  Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. , 2007, Cancer letters.

[13]  X. Bustelo,et al.  GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo , 2007, BioEssays : news and reviews in molecular, cellular and developmental biology.

[14]  K. Nagata,et al.  Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons , 2006, Neuroscience Research.

[15]  Q. Feng,et al.  Identification of a DOCK180-related Guanine Nucleotide Exchange Factor That Is Capable of Mediating a Positive Feedback Activation of Cdc42* , 2006, Journal of Biological Chemistry.

[16]  Arpad M. Danos,et al.  Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways. , 2006, American journal of physiology. Endocrinology and metabolism.

[17]  M. Neurath,et al.  Azathioprine Suppresses Ezrin-Radixin-Moesin-Dependent T Cell-APC Conjugation through Inhibition of Vav Guanosine Exchange Activity on Rac Proteins , 2006, The Journal of Immunology.

[18]  R. Geha,et al.  Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome. , 2005, The Journal of allergy and clinical immunology.

[19]  T. Klabunde,et al.  Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. , 2005, Journal of medicinal chemistry.

[20]  V. Tybulewicz,et al.  Vav-family proteins in T-cell signalling. , 2005, Current opinion in immunology.

[21]  O. Bernard,et al.  Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2. , 2004, The Biochemical journal.

[22]  X. Bustelo,et al.  Inverted signaling hierarchy between RAS and RAC in T-lymphocytes , 2004, Oncogene.

[23]  Yi Zheng,et al.  Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  K. Frauwirth,et al.  Regulation of T Lymphocyte Metabolism , 2004, The Journal of Immunology.

[25]  J. Shively,et al.  The Cell-Cell Adhesion Molecule Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Inhibits IL-2 Production and Proliferation in Human T Cells by Association with Src Homology Protein-1 and Down-Regulates IL-2 Receptor1 , 2004, The Journal of Immunology.

[26]  G. Bokoch.  Biology of the p21-activated kinases. , 2003, Annual review of biochemistry.

[27]  A. Monks,et al.  Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression. , 2003, Biochemical and biophysical research communications.

[28]  S. Meloche,et al.  Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors , 2003, Molecular and Cellular Biology.

[29]  N. Westergaard,et al.  The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors. , 2002, The Biochemical journal.

[30]  W. Pawlina,et al.  Glycogen phosphorylase is activated in response to glucose deprivation but is not responsible for enhanced glucose transport activity in 3T3-L1 adipocytes. , 2002, Biochimica et biophysica acta.

[31]  H. Rui,et al.  Functional Uncoupling of the Janus Kinase 3-Stat5 Pathway in Malignant Growth of Human T Cell Leukemia Virus Type 1-Transformed Human T Cells1 , 2000, The Journal of Immunology.

[32]  A. Trautmann,et al.  Rac Is Involved in Early TCR Signaling1 , 2000, The Journal of Immunology.

[33]  Wange Lu,et al.  Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch , 2000, Cell.

[34]  V. L. Rath,et al.  Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core. , 2000, Molecular cell.

[35]  E. Laue,et al.  Structure of Cdc42 bound to the GTPase binding domain of PAK , 2000, Nature Structural Biology.

[36]  J. Bertoglio,et al.  IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes , 2000, Oncogene.

[37]  B. Nelson,et al.  The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat51 , 2000, The Journal of Immunology.

[38]  P. Más,et al.  A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation. , 2000, Immunity.

[39]  A. Mortellaro,et al.  New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. , 1999, Journal of immunology.

[40]  K. Siminovitch,et al.  Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein , 1999, Nature.

[41]  D. Bar-Sagi,et al.  A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production* , 1998, The Journal of Biological Chemistry.

[42]  A. Trautmann,et al.  Involvement of phosphoinositide 3‐kinase and Rac in membrane ruffling induced by IL‐2 in T cells , 1998, European journal of immunology.

[43]  B. Groner,et al.  Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. , 1997, Immunity.

[44]  L. Van Aelst,et al.  Rho GTPases and signaling networks. , 1997, Genes & development.

[45]  D. Bar-Sagi,et al.  RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase , 1996, Science.

[46]  K. Fujisawa,et al.  Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain* , 1996, The Journal of Biological Chemistry.

[47]  S. Fesik,et al.  Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[48]  W. Leonard,et al.  Cloning of Human Stat5B , 1996, The Journal of Biological Chemistry.

[49]  A. Hall,et al.  A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases (*) , 1995, The Journal of Biological Chemistry.

[50]  S. Shoelson,et al.  Interaction of Shc with Grb2 Regulates the Grb2 Association with mSOS , 1995, Annals of the New York Academy of Sciences.

[51]  C. Nobes,et al.  Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia , 1995, Cell.

[52]  P. Højrup,et al.  Rapid identification of proteins by peptide-mass fingerprinting , 1993, Current Biology.

[53]  L. Johnson,et al.  The molecular mechanism for the tetrameric association of glycogen phosphorylase promoted by protein phosphorylation , 1992, Protein science : a publication of the Protein Society.

[54]  R. Fletterick,et al.  Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. , 1988, The Journal of biological chemistry.

[55]  H. Ohno,et al.  Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus. , 1987, Blood.

[56]  F. Ruscetti.  Biology of interleukin-2 , 1984, Survey of immunologic research.

[57]  W. Thompson,et al.  Effects of insulin on glycogen metabolism of serum‐deprived BHK‐21 fibroblasts , 1980, Journal of cellular physiology.

[58]  J. Dreyfus,et al.  The isozymes of glycogen phosphorylase in human and rabbit tissues. II. Electrofocusing in polyacrylamide gels. , 1974, Clinica chimica acta; international journal of clinical chemistry.

[59]  J. Dreyfus,et al.  Phosphorylase isoenzymes in tissues: prevalence of the liver type in man. , 1973, Clinica chimica acta; international journal of clinical chemistry.

[60]  A. Yunis,et al.  Isoenzymes of glycogen phosphorylase in human leukocytes and platelets: relation to muscle phosphorylase. , 1968, Biochemical and biophysical research communications.

[61]  Y. Gon,et al.  The Rac1/JNK pathway is critical for EGFR-dependent barrier formation in human airway epithelial cells. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[62]  Jing Zhanga,et al.  GRB 2 couples RhoU to epidermal growth factor receptor signaling and cell migration , 2011 .

[63]  P. Crespo,et al.  Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors. , 2010, Methods in molecular biology.

[64]  D. Billadeau,et al.  T cell activation and the cytoskeleton: you can't have one without the other. , 2008, Advances in immunology.

[65]  H. Vetter,et al.  Epidermal growth factor stimulates Rac1 and p21-activated kinase in vascular smooth muscle cells. , 2008, Atherosclerosis.

[66]  K. Schwarz,et al.  The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis. , 2001, Blood.

[67]  G. B. Golding,et al.  Evolution of allosteric control in glycogen phosphorylase. , 1993, Journal of molecular biology.

[68]  H. Hidaka,et al.  Properties and use of H-series compounds as protein kinase inhibitors. , 1991, Methods in enzymology.

[69]  Daly Jw,et al.  Forskolin: its biological and chemical properties. , 1986, Advances in cyclic nucleotide and protein phosphorylation research.